Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers

Elmas, Bahri; DERVİŞOĞLU ÇAVDAROĞLU, PINAR; KÖSECİK, Mustafa; İŞGÜVEN, Şükriye Pınar; bal, ceylan; KARACAN, Mehmet

Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers

Bahri ELMAS, (for correspondence: Dr. , Sakarya Üniversitesi Tıp Fakültesi Pediyatri Bölümü, Sakarya-Türkiye E-mail: ©Copyright 2017 by Turkish Society of Cardiology - Available online at www.anatoljcardiol.com DOI:10.14744/AnatolJCardiol.2017.7740)

Mehmet KARACAN, (Pediatric Cardiology, Faculty of Medicine, Medipol University; İstanbul-Turkey)

PINAR DERVİŞOĞLU ÇAVDAROĞLU, (for correspondence: Dr. , Sakarya Üniversitesi Tıp Fakültesi Pediyatri Bölümü, Sakarya-Türkiye E-mail: ©Copyright 2017 by Turkish Society of Cardiology - Available online at www.anatoljcardiol.com DOI:10.14744/AnatolJCardiol.2017.7740)

Mustafa KÖSECİK, (for correspondence: Dr. , Sakarya Üniversitesi Tıp Fakültesi Pediyatri Bölümü, Sakarya-Türkiye E-mail: ©Copyright 2017 by Turkish Society of Cardiology - Available online at www.anatoljcardiol.com DOI:10.14744/AnatolJCardiol.2017.7740)

Şükriye Pınar İŞGÜVEN, (Pediatric Endocrinology, Faculty of Medicine, Sakarya University; Sakarya-Turkey)

Ceylan BAL (Biochemistry, Faculty of Medicine, Yıldırım Beyazıt University; Ankara-Turkey)

The Anatolian Journal of Cardiology

3 0

Yıl: 2017 Cilt: 18 Sayı: 5 Sayfa Aralığı: 361 - 369 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers

Öz:

Objective: Childhood obesity is an important cause of cardiovascular risk with chronic inflammation. Oxidative stress may contribute to the pathogenesis of obesity-related cardiovascular pathologies. We aimed to evaluate thiol/disulphide homeostasis as a novel and sensitive marker of oxidative stress and to evaluate its relationship with some inflammatory and cardiovascular markers in obese children.Methods: In this case-controlled study, 65 children with exogenous obesity and 64 healthy children, as a control group, were included. In both groups, thiol/disulphide homeostasis parameters and inflammatory (white blood cells, platelets, mean corpuscular volume, neutrophil/lymphocyte ratio, and high-sensitivity C-reactive protein) and cardiovascular (epicardial adipose tissue thickness and left ventricular mass index) markers were studied. Correlation analyses of thiol/disulphide homeostasis parameters with body mass index standard deviation scores (BMI SDS) and inflammatory and cardiovascular markers were performed. Receiver-operating characteristic analysis was performed to determine the sensitivity, specificity, and optimal cut-off values of thiol/disulphide homeostasis parameters.Results: Native thiol, total thiol, and native thiol/total thiol ratios (antioxidant parameters) were lower (p<0.05) and disulphide/native thiol and disulphide/total thiol ratios (oxidant parameters) were higher in the obese group than in the control group (p<0.01). A positive correlation of oxidant parameters with BMI SDS and inflammatory markers was found. However, a negative correlation of antioxidant parameters with BMI SDS and inflammatory markers was found. The specificities of disulphide/native thiol and disulphide/total thiol ratios were higher in the obese group.Conclusion: The impairment in thiol/disulphide homeostasis, which is indicative of oxidative stress, is associated with inflammation in obesity. In addition, cardiovascular involvement may also contribute to this impairment.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Elmas B, KARACAN M, DERVİŞOĞLU ÇAVDAROĞLU P, KÖSECİK M, İŞGÜVEN Ş, bal c (2017). Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. , 361 - 369.
Chicago	Elmas Bahri,KARACAN Mehmet,DERVİŞOĞLU ÇAVDAROĞLU PINAR,KÖSECİK Mustafa,İŞGÜVEN Şükriye Pınar,bal ceylan Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. (2017): 361 - 369.
MLA	Elmas Bahri,KARACAN Mehmet,DERVİŞOĞLU ÇAVDAROĞLU PINAR,KÖSECİK Mustafa,İŞGÜVEN Şükriye Pınar,bal ceylan Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. , 2017, ss.361 - 369.
AMA	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. . 2017; 361 - 369.
Vancouver	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. . 2017; 361 - 369.
IEEE	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c "Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers." , ss.361 - 369, 2017.
ISNAD	Elmas, Bahri vd. "Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers". (2017), 361-369.

APA	Elmas B, KARACAN M, DERVİŞOĞLU ÇAVDAROĞLU P, KÖSECİK M, İŞGÜVEN Ş, bal c (2017). Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. The Anatolian Journal of Cardiology, 18(5), 361 - 369.
Chicago	Elmas Bahri,KARACAN Mehmet,DERVİŞOĞLU ÇAVDAROĞLU PINAR,KÖSECİK Mustafa,İŞGÜVEN Şükriye Pınar,bal ceylan Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. The Anatolian Journal of Cardiology 18, no.5 (2017): 361 - 369.
MLA	Elmas Bahri,KARACAN Mehmet,DERVİŞOĞLU ÇAVDAROĞLU PINAR,KÖSECİK Mustafa,İŞGÜVEN Şükriye Pınar,bal ceylan Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. The Anatolian Journal of Cardiology, vol.18, no.5, 2017, ss.361 - 369.
AMA	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. The Anatolian Journal of Cardiology. 2017; 18(5): 361 - 369.
Vancouver	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers. The Anatolian Journal of Cardiology. 2017; 18(5): 361 - 369.
IEEE	Elmas B,KARACAN M,DERVİŞOĞLU ÇAVDAROĞLU P,KÖSECİK M,İŞGÜVEN Ş,bal c "Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers." The Anatolian Journal of Cardiology, 18, ss.361 - 369, 2017.
ISNAD	Elmas, Bahri vd. "Dynamic thiol/disulphide homeostasis as a novel indicator of oxidative stress in obese children and its relationship with inflammatory-cardiovascular markers". The Anatolian Journal of Cardiology 18/5 (2017), 361-369.