Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

GÜR, Emel; BAHAR TOKMAN, HRİSİ; Gonullu, Nevriye; ÇOKUĞRAŞ, HALUK CEZMİ; Taner, Zeynep; ARVAS, Ahmet

Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

Ahmet ARVAS, (Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

HALUK CEZMİ ÇOKUĞRAŞ, (Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

Emel GÜR, (Department of Paediatrics, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

Nevriye GÖNÜLLÜ, (Department of Medical Microbiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

Zeynep TANER, (Department of Medical Microbiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

Hrisi Bahar TOKMAN (Department of Medical Microbiology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey)

Balkan Medical Journal

2 0

Yıl: 2017 Cilt: 34 Sayı: 4 Sayfa Aralığı: 362 - 366 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey

Öz:

Aims: To determine the prevalence of nasopharyngealcarriage of Streptococcus pneumoniae in healthy childrenaged 0-6 years who were vaccinated with pneumococcalconjugate vaccine.Methods: This cross-sectional study was conducted on150 healthy Turkish children between 1 month and 6years of age. Serotyping was performed and risk factorsof carriage were evaluated.Results: The overall carriage rate was 14%. Vaccinetype serotypes were determined in 17 (12.6%) childrenwho received full-dose PCV13 vaccine. The highestcarriage rate was observed among children youngerthan 24 months (76.2%). In multivariate analysis,respiratory infection in recent months, age, attendanceat a day-care center and antibiotic usage were notstatistically significant risk factors for carriage. Overall,S. pneumoniae strains were considered as penicillinsusceptible and antimicrobial resistance was limited.Conclusion: We observed a low rate of pneumococcalcarriage in children after PCV13 implementationcompared with that of children receiving PCV7.Although it was reduced, vaccine serotype colonizationin PCV13-vaccinated children remains persistent.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Centers for Disease Control and Prevention (CDC) Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease United States, 1998-2003. MMWR Morb Mortal Wkly Rep 2005;54:893-7.
2. Fitzwater SP, Chandran A, Santosham M, Johnson HL. The worldwide impact of the seven-valent pneumococcal conjugate vaccine. Pediatr Infect Dis J 2012;31:501-8.
3. Chapman KE, Wilson D, Gorton R. Serotype dynamics of invasive pneumococcal disease post PCV-7 and pre PCV-13 introduction in North East England. Epidemiol Infect 2013;141:344-52.
4. Hackel M, Lascols C, Bouchillon S, Hilton B, Morgenstern D, Purdy J. Serotype prevalence and antibiotic resistance in Streptococcus pneumoniae clinical isolates among global population. Vaccine 2013;31:4881-7.
5. Ceyhan M, Gurler N, Yaman A, Ozturk C, Oksuz L, Ozkan S, et al. Sertypes of Streptococcus pneumoniae isolates from children with invasive pneumococcal disease in Turkey: baseline evaluation of the introduction of the pneumococcal conjugate vaccine nationwide. Clin Vaccine Immunol 2011;18:1028-30.
6. Slotved HC, Kaltoft M, Skovsted IC, Kerrn MB, Espersen F. Simple rapid latex agglutination test for serotyping of pneumococci (Pneumotest-Latex). J Clin Microbiol 2004;42:2518-22.
7. Shutt CK, Samore M, Carroll CK. Comparison of the denka seiken slide agglutination method to the quellung test for serogrouping of Streptococcus pneumoniae isolates. J Clin Microbiol 2004;42:1274-6.
8. European Committee on Antimicrobial Susceptibility Testing. Breakpoint tables for interpretation of MICs and zone diameters. Version 5.0, 2015. Available from: http://www.eucast.org (7 July 2015, date last accessed).
9. Nzenze SA, Shiri T, Nunes MC, Klugman KP, Kahn K, Twine R, et al. Temporal association of infant immunization with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus inluenzae and Staphylococcus aureus nasopharyngeal colonization in a rural South African community. Vaccine 2014;32:5520-30.
10. Daana M, Rahav G, Hamdan A, Thalji A, Jaar F, Abdeen Z, et al. Measuring the effects of pneumococcal conjugate vaccine (PCV7) on Streptococcus pneumoniae carriage and antibiotic resistance: The Palestinian-Israeli Collaborative Research (PICR). Vaccine 2015;33:1023-6.
11. Dagan R, Patterson S, Juergens C, Greenberg D, Givon-Lavi N, Porat N, et al. Comparative immunogenicity and efficacy of 13-valent and 7-valent pneumococcal conjugate vaccines in reducing nasopharyngeal colonization: a randomized double-blind trial. Clin Infect Dis 2013;57:952- 62.
12. Zuccotti G, Mameli C, Daprai L, Garlaschi ML, Dilillo D, Bedogni G, et al. Serotype distribution and antimicrobial susceptibilities of nasopharyngeal isolates of Streptococcus pneumoniae from healthy children in the 13-valent pneumococcal conjugate vaccine era. Vaccine 2014;32:527-34.
13. Tothpal A, Kardos S, Laub K, Nagy K, Tirczka T, van der Linden M, et al. Radical serotype rearrangement of carrier pneumococci in the first 3 years after intensive vaccination started in Hungary. Eur J Pediatr 2015;174:373- 81.
14. Scott JR, Millar EV, Lipsitch M, Moulton LH, Weatherholtz R, Perilla MJ, et al. Impact of more than a decade of pneumococcal conjugate vaccine use on carriage and invasive potential in Native American communities. J Infect Dis 2012;205:280-8.
15. Dunais B, Bruno P, Touboul P, Degand N, Sakarovitch C, Fontas E, et al. Impact of the 13-valent pneumococcal conjugate vaccine on nasopharyngeal carriage of Streptococcus pneumoniae among children attending group daycare in southeastern France. Pediatr Infect Dis J 2015;34:286-8.
16. Lee GM, Kleinman K, Pelton SI, Hanage W, Huang SS, Lakoma M, et al. Impact of the 13-valent pneumococcal conjugate vaccine on Streptococcus pneumoniae carriage in young children in Massachusettes. J Pediatr Infect Dis Soc 2014;3:23-32.
17. Özdemir H, Çiftçi E, Durmaz R, Güriz H, Aysev AD, Karbuz A, et al. Risk factors for nosopharyngeal carriage of Streptococcus pneumoniae in healthy Turkish children after the addition of heptavalent pneumococcal conjugate vaccine (PCV7) to the national vaccine schedule. Turk J Pediatr 2013;55:575-83.
18. Soysal A, Karabağ-Yılmaz E, Kepenekli E, Karaaslan A, Cagan E, Atıcı S, et al. The impact of a pneumococcal vaccination program on the nasopharyngeal carriage, serotype distribution and antimicrobial resistance of Streptococcus pneumoniae among healthy children in Turkey. Vaccine 2016;34:3894-900.
19. Grivea IN, Priftis KN, Giotas A, Kotzia D, Tsantouli AG, Douros K, et al. Dynamics of pneumococcal carriage among day-care center attendees during the transition form the 7-valent to the higher-valent pneumoccal conjugate vaccines in Greece. Vaccine 2014;32:6513-20.
20. Rivera-Olivero IA, del Nogal B, Fuentes M, Cortez R, Bogaert D, Hermans PW, et al. Immunogenicity of a 7-valent pneumococcal conjugate vaccine (PCV7) and impact on carriage in Venezuelan children at risk of invasive pneumococcal diseases. Vaccine 2014;32:4006-11.

APA	ARVAS A, ÇOKUĞRAŞ H, GÜR E, Gonullu N, Taner Z, BAHAR TOKMAN H (2017). Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. , 362 - 366.
Chicago	ARVAS Ahmet,ÇOKUĞRAŞ HALUK CEZMİ,GÜR Emel,Gonullu Nevriye,Taner Zeynep,BAHAR TOKMAN HRİSİ Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. (2017): 362 - 366.
MLA	ARVAS Ahmet,ÇOKUĞRAŞ HALUK CEZMİ,GÜR Emel,Gonullu Nevriye,Taner Zeynep,BAHAR TOKMAN HRİSİ Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. , 2017, ss.362 - 366.
AMA	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. . 2017; 362 - 366.
Vancouver	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. . 2017; 362 - 366.
IEEE	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H "Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey." , ss.362 - 366, 2017.
ISNAD	ARVAS, Ahmet vd. "Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey". (2017), 362-366.

APA	ARVAS A, ÇOKUĞRAŞ H, GÜR E, Gonullu N, Taner Z, BAHAR TOKMAN H (2017). Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal, 34(4), 362 - 366.
Chicago	ARVAS Ahmet,ÇOKUĞRAŞ HALUK CEZMİ,GÜR Emel,Gonullu Nevriye,Taner Zeynep,BAHAR TOKMAN HRİSİ Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal 34, no.4 (2017): 362 - 366.
MLA	ARVAS Ahmet,ÇOKUĞRAŞ HALUK CEZMİ,GÜR Emel,Gonullu Nevriye,Taner Zeynep,BAHAR TOKMAN HRİSİ Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal, vol.34, no.4, 2017, ss.362 - 366.
AMA	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal. 2017; 34(4): 362 - 366.
Vancouver	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey. Balkan Medical Journal. 2017; 34(4): 362 - 366.
IEEE	ARVAS A,ÇOKUĞRAŞ H,GÜR E,Gonullu N,Taner Z,BAHAR TOKMAN H "Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey." Balkan Medical Journal, 34, ss.362 - 366, 2017.
ISNAD	ARVAS, Ahmet vd. "Pneumococcal Nasopharyngeal Carriage in Young Healthy Children After Pneumococcal Conjugate Vaccine in Turkey". Balkan Medical Journal 34/4 (2017), 362-366.