Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi

Eskiizmir, Görkem

Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi

Görkem ESKİİZMİR (Celal Bayar Üniversitesi Tıp Fakültesi, Kulak Burun Boğaz ve Baş Boyun Cerrahisi Anabilim Dalı, Manisa, Türkiye)

Türk Otorinolarengoloji Arşivi

5 0

Yıl: 2015 Cilt: 53 Sayı: 3 Sayfa Aralığı: 120 - 127 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi

Öz:

Solid tümörlerin progresyonu, agresivitesi ve metastaz yeteneği kazanması ile ilgili olarak son yıllarda yapılan çalışmalar, kanser hücrelerindeki genetik bozulmaların ve moleküler değişikliklerin yanı sıra tümör mikroçevresinin de Önemli rol oynadığını ortaya koymuştur. Tümör mikroçevresindeki kanser hücrelerinin kanser dışı hücrelerle olan iletişimi ve mikroçevrede yarattıkları metabolik değişiklikler ciddi etkiler yaratmaktadır. Bu derlemenin amacı baş boyun yassı hücreli karsinomlarının tümör mikroçevresindeki kanser ve kanser dışı hücrelerin aralarındaki iletişim yollarının ve birbirlerine etkilerinin, bu ortamda ortaya çıkan metabolik değişikliklerin etkilerinin sunulması ve tüm bu faktörlerin klinik öneminin güncel literatür ışığında tartışılmasıdır.

Anahtar Kelime:

Konular: Patoloji Onkoloji

Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas

Öz:

Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purpose of this review is to present the role and effect of noncancerous cells and their crosstalks With cancer cells, metabolic changes in tumor microenvironment, and to discuss the clinical significance of all these factors with respect to the current literature.

Anahtar Kelime:

Konular: Patoloji Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Eskiizmir G (2015). Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. , 120 - 127.
Chicago	Eskiizmir Görkem Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. (2015): 120 - 127.
MLA	Eskiizmir Görkem Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. , 2015, ss.120 - 127.
AMA	Eskiizmir G Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. . 2015; 120 - 127.
Vancouver	Eskiizmir G Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. . 2015; 120 - 127.
IEEE	Eskiizmir G "Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi." , ss.120 - 127, 2015.
ISNAD	Eskiizmir, Görkem. "Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi". (2015), 120-127.

APA	Eskiizmir G (2015). Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. Türk Otorinolarengoloji Arşivi, 53(3), 120 - 127.
Chicago	Eskiizmir Görkem Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. Türk Otorinolarengoloji Arşivi 53, no.3 (2015): 120 - 127.
MLA	Eskiizmir Görkem Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. Türk Otorinolarengoloji Arşivi, vol.53, no.3, 2015, ss.120 - 127.
AMA	Eskiizmir G Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. Türk Otorinolarengoloji Arşivi. 2015; 53(3): 120 - 127.
Vancouver	Eskiizmir G Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi. Türk Otorinolarengoloji Arşivi. 2015; 53(3): 120 - 127.
IEEE	Eskiizmir G "Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi." Türk Otorinolarengoloji Arşivi, 53, ss.120 - 127, 2015.
ISNAD	Eskiizmir, Görkem. "Baş Boyun Yassı Hücreli Karsinomlarında Tümör Mikroçevresi". Türk Otorinolarengoloji Arşivi 53/3 (2015), 120-127.