Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?

STAVRAKİS, Thomas; ANAGNOSTİS, Panagiotis; AGAPİDOU, Alexandra; VLACHAKİ, Efthymia; VAKALOPOULOU, Sophia

Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?

Alexandra AGAPİDOU, (Aristotle University, Hippokration Hospital, Second Propaedeutic Department of Internal Medicine, Thessaloniki, Greece)

Thomas STAVRAKİS, (Aristotle University, Hippokration Hospital, Second Propaedeutic Department of Internal Medicine, Thessaloniki, Greece)

Efthymia VLACHAKİ, (Aristotle University, Hippokration Hospital, Second Department of Internal Medicine, Thessaloniki, Greece)

Panagiotis ANAGNOSTİS, (Aristotle University, Hippokration Hospital, Second Propaedeutic Department of Internal Medicine, Thessaloniki, Greece)

Sophia VAKALOPOULOU (Aristotle University, Hippokration Hospital, Second Propaedeutic Department of Internal Medicine, Thessaloniki, Greece)

Turkish Journal of Hematology

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Yıl: 2016 Cilt: 33 Sayı: 2 Sayfa Aralığı: 88 - 93 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?

Öz:

Hemofili, hastanın kas ve iskelet sistemini etkileyen, tekrarlayan kanama atakları ile dejeneratif eklem artropatisine neden olan, kalıtsal bir kanama bozukluğudur. Kanama travma sonrasında ya da kendiliğinden olabilir. Hemofilik artropatinin patogenezi kesin bilinmemekle birlikte, demir, yangı sitokinleri ve anjiyogenik faktörlerin sürece katkıları vardır. Eklem içine kanama kemiği bir düzeye kadar bozabilir ve hasta, yaşam kalitesi üzerine büyük bir etkisi olan ağrı, hareket kısıtlılığı ve eklem deformitesi gibi durumları yaşar. Yıllar içerisinde hemofilik artropatinin yönetiminde değişiklikler olmuştur. Günümüzde manyetik rezonans görüntüleme gibi yüksek çözünürlüklü görüntüleme yöntemleri ile erken tanı ve profilaksi rejimlerinin kullanılması eklemlerdeki harabiyetin derecesini azaltmaktadır. Ancak bunların ücretleri bazı hastalar açısından sınırlayıcı olabileceğinden, tüm hastalar bu müdahalelere ulaşamaz. Erken dönemdeki değişiklikleri tespit edebilen yeni, kolay ve maliyet etkin stratejiler yararlı olabilir ve hemofilik artropatinin yönetiminde bir değişiklik yapabilir. Artropati gelişim mekanizmalarından anjiyogenez gibi süreçlerin mekanizmasının anlaşılması bu hastalar için bir yenilik olabilir ve yeni erken tanısal ve terapötik belirteçlerin bulunmasına yardımcı olabilir

Anahtar Kelime:

Konular: Hematoloji

The Role of Angiogenesis in Haemophilic Arthropathy: Where Do We Stand and Where Are We Going?

Öz:

1Aristotle University, Hippokration Hospital, Second Propaedeutic Department of Internal Medicine, Thessaloniki, Greece2Aristotle University, Hippokration Hospital, Second Department of Internal Medicine, Thessaloniki, GreeceAlexandra Agapidou1, Thomas Stavrakis1, Efthymia Vlachaki2, Panagiotis Anagnostis1, Sophia Vakalopoulou1The Role of Angiogenesis in Haemophilic Arthropathy: Where Do Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?We Stand and Where Are We Going?health provider’s side. If a patient cannot receive prophylactic treatment, there are various other ways of chronic joint pain relief, like applying interventions such as synovectomy and arthroplasty. These are invasive surgical procedures that may be frustrating for the patient. It is important to realise that the mechanism underlying progressive haemophilic arthropathy is multifactorial and still remains unclear. Availability of an easy, quick, and low-cost test with high specificity for diagnosing HJD would be beneficial for both patients and health providers. Use of the Fracture Risk Assessment Tool for assessing fracture risk, regular bone mineral density assessment, and supplemented calcium, vitamin D, and, in specific cases, bisphosphonate intake, as well as long-term prophylactic factor replacement therapy, were suggested as means of prevention of bone loss [2]. Furthermore, various inflammatory and angiogenetic processes have been implicated in early joint bleeding and in the pathogenesis of HJD. Achieving a deeper knowledge of HJD could potentially lead to earlier diagnosis and treatment in patients with haemophilia

Anahtar Kelime:

Konular: Hematoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	AGAPİDOU A, STAVRAKİS T, VLACHAKİ E, ANAGNOSTİS P, VAKALOPOULOU S (2016). Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. , 88 - 93.
Chicago	AGAPİDOU Alexandra,STAVRAKİS Thomas,VLACHAKİ Efthymia,ANAGNOSTİS Panagiotis,VAKALOPOULOU Sophia Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. (2016): 88 - 93.
MLA	AGAPİDOU Alexandra,STAVRAKİS Thomas,VLACHAKİ Efthymia,ANAGNOSTİS Panagiotis,VAKALOPOULOU Sophia Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. , 2016, ss.88 - 93.
AMA	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. . 2016; 88 - 93.
Vancouver	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. . 2016; 88 - 93.
IEEE	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S "Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?." , ss.88 - 93, 2016.
ISNAD	AGAPİDOU, Alexandra vd. "Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?". (2016), 88-93.

APA	AGAPİDOU A, STAVRAKİS T, VLACHAKİ E, ANAGNOSTİS P, VAKALOPOULOU S (2016). Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. Turkish Journal of Hematology, 33(2), 88 - 93.
Chicago	AGAPİDOU Alexandra,STAVRAKİS Thomas,VLACHAKİ Efthymia,ANAGNOSTİS Panagiotis,VAKALOPOULOU Sophia Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. Turkish Journal of Hematology 33, no.2 (2016): 88 - 93.
MLA	AGAPİDOU Alexandra,STAVRAKİS Thomas,VLACHAKİ Efthymia,ANAGNOSTİS Panagiotis,VAKALOPOULOU Sophia Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. Turkish Journal of Hematology, vol.33, no.2, 2016, ss.88 - 93.
AMA	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. Turkish Journal of Hematology. 2016; 33(2): 88 - 93.
Vancouver	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?. Turkish Journal of Hematology. 2016; 33(2): 88 - 93.
IEEE	AGAPİDOU A,STAVRAKİS T,VLACHAKİ E,ANAGNOSTİS P,VAKALOPOULOU S "Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?." Turkish Journal of Hematology, 33, ss.88 - 93, 2016.
ISNAD	AGAPİDOU, Alexandra vd. "Hemofilik Artropatide Anjiyogenezin Rolü: Neredeyiz ve Nereye Gidiyoruz?". Turkish Journal of Hematology 33/2 (2016), 88-93.