Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study

Uygun, Ibrahim; TOPRAK, Gülten; Tan, ilhan; ARSLAN, SERKAN; İBİLOĞLU, İbrahim; ZEYTUN, Hikmet; yılmaz, ahmet; BASUGUY, Erol

Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study

Serkan ARSLAN, (Department of Pediatric Surgery, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

Hikmet ZEYTUN, (Department of Pediatric Surgery, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

Erol BASUGUY, (Department of Pediatric Surgery, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

İbrahim İBİLOĞLU, (Department of Pathology, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

İbrahim UYGUN, (Department of Pediatric Surgery, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

Ahmet YILMAZ, (Department of Family Medicine, Dicle University Faculty of Medicine, Diyarbakır-Turke)

İlhan TAN, (Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

Gülten TOPRAK (Department of Pediatrics, Dicle University Faculty of Medicine, Diyarbakır-Turkey)

Ulusal Travma ve Acil Cerrahi Dergisi

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Yıl: 2017 Cilt: 23 Sayı: 4 Sayfa Aralığı: 273 - 278 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study

Öz:

BACKGROUND: The aim of the present study was to investigate whether cordycepin prevented adhesion formation in a rat model.METHODS: Rats were randomly assigned to 3 groups of 10 rats. Control group: The absence of adhesion was confirmed via laparotomy. Adhesion group: The cecum was removed from the abdomen and scraped with a dry gauze bandage until petechial hemorrhagic foci developed. Cordycepin group: The same surgical procedure was performed as in the adhesion group, and 10 mg/kg cordycepin was administered intraperitoneally. After 15 days, the rats were sacrificed humanely via cardiac blood withdrawal under anesthesia. The rats were then analyzed morphologically and histopathologically, and hydroxyproline (OH-p) and malondialdehyde (MDA) levels were measured.RESULTS: Macroscopic analysis revealed significantly less adhesion in the cordycepin group than in the adhesion group (p<0.01). Furthermore, significant histopathological improvement was also evident in the cordycepin group compared to the adhesion group (p<0.05). The levels of OH-p and MDA in blood and tissue were higher in the adhesion group than in the control group, and lower in the cordycepin group than the adhesion group. Interestingly, MDA level was significantly lower (blood: p<0.05; tissue: p<0.01) in the cordycepin group than in the adhesion group, whereas only tissue OH-p was significantly lower in the cordycepin group compared with the adhesion group (p<0.05). One rat in both adhesion group and cordycepin group died postoperatively.CONCLUSION: Results indicated that cordycepin effectively reduced adhesion in a rat abrasion model. Thus, this agent may be valuable to prevent postoperative adhesion

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ARSLAN S, ZEYTUN H, BASUGUY E, İBİLOĞLU İ, Uygun I, yılmaz a, Tan i, TOPRAK G (2017). Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. , 273 - 278.
Chicago	ARSLAN SERKAN,ZEYTUN Hikmet,BASUGUY Erol,İBİLOĞLU İbrahim,Uygun Ibrahim,yılmaz ahmet,Tan ilhan,TOPRAK Gülten Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. (2017): 273 - 278.
MLA	ARSLAN SERKAN,ZEYTUN Hikmet,BASUGUY Erol,İBİLOĞLU İbrahim,Uygun Ibrahim,yılmaz ahmet,Tan ilhan,TOPRAK Gülten Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. , 2017, ss.273 - 278.
AMA	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. . 2017; 273 - 278.
Vancouver	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. . 2017; 273 - 278.
IEEE	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G "Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study." , ss.273 - 278, 2017.
ISNAD	ARSLAN, SERKAN vd. "Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study". (2017), 273-278.

APA	ARSLAN S, ZEYTUN H, BASUGUY E, İBİLOĞLU İ, Uygun I, yılmaz a, Tan i, TOPRAK G (2017). Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, 23(4), 273 - 278.
Chicago	ARSLAN SERKAN,ZEYTUN Hikmet,BASUGUY Erol,İBİLOĞLU İbrahim,Uygun Ibrahim,yılmaz ahmet,Tan ilhan,TOPRAK Gülten Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi 23, no.4 (2017): 273 - 278.
MLA	ARSLAN SERKAN,ZEYTUN Hikmet,BASUGUY Erol,İBİLOĞLU İbrahim,Uygun Ibrahim,yılmaz ahmet,Tan ilhan,TOPRAK Gülten Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi, vol.23, no.4, 2017, ss.273 - 278.
AMA	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2017; 23(4): 273 - 278.
Vancouver	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study. Ulusal Travma ve Acil Cerrahi Dergisi. 2017; 23(4): 273 - 278.
IEEE	ARSLAN S,ZEYTUN H,BASUGUY E,İBİLOĞLU İ,Uygun I,yılmaz a,Tan i,TOPRAK G "Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study." Ulusal Travma ve Acil Cerrahi Dergisi, 23, ss.273 - 278, 2017.
ISNAD	ARSLAN, SERKAN vd. "Cordycepin prevents postoperative formation of intra-abdominal adhesion in a rat model: An experimental study". Ulusal Travma ve Acil Cerrahi Dergisi 23/4 (2017), 273-278.