Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

YILMAZ, Gülderen; ÖZBEK, HİLAL; KAZAZ, CAVİT; YERDELEN, Kadir Özden; DEMIREZER, LUTFIYE OMUR; GÜVENALP, ZÜHAL

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

Zühal GÜVENALP, (Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Türkiye)

Hilal ÖZBEK, (Department of Pharmacognosy, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Türkiye)

Kadir Özden YERDELEN, (Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Atatürk University, Erzurum 25240, Türkiye)

Gülderen YILMAZ, (Department of Pharmaceutical Botany, Faculty of Pharmacy, Ankara University, Ankara 06100, Türkiye)

Cavit KAZAZ, (Department of Chemistry, Faculty of Science, Atatürk University, Erzurum 25240, Türkiye)

Lütfiye Ömür DEMİREZER (Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Ankara 06100, Türkiye)

Records of Natural Products

2 0

Yıl: 2017 Cilt: 11 Sayı: 5 Sayfa Aralığı: 462 - 505 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica

Öz:

Five sesquiterpene coumarin ethers: umbelliprenin, umbelliprenin-10',11'-monoepoxide, conferone, mogoltacin and feselol were isolated from the fruits of Heptaptera cilicica. Their structures were identified by means of spectroscopic methods. AChE and BuChE inhibitory activities of the compounds were determined by molecular docking method which were confirmed by in vitro experiments. According to molecular docking results, total score of feselol and umbelliprenin were 5.69 and 3.23 kcal/mol against acetylcholinesterase, respectively. Total score for butyrylcholinesterase inhibitory effect of them were 2.76 and 4.99 kcal/mol, respectively. Feselol and umbelliprenin exhibited significantly high inhibitory potency against acetylcholinesterase (IC50 = 1.26 ± 0.01 and 5.86 ± 0.03 μM, respectively) and butyrylcholinesterase (IC50 = 9.98 ± 0.24 and 1.10 ± 0.19 μM, respectively). This is the first report of isolation of natural bioactives obtained from the chloroform extract of Heptaptera cilicica fruits with anticholinesterase activity

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APA	GÜVENALP Z, ÖZBEK H, YERDELEN K, YILMAZ G, KAZAZ C, DEMIREZER L (2017). Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. , 462 - 505.
Chicago	GÜVENALP ZÜHAL,ÖZBEK HİLAL,YERDELEN Kadir Özden,YILMAZ Gülderen,KAZAZ CAVİT,DEMIREZER LUTFIYE OMUR Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. (2017): 462 - 505.
MLA	GÜVENALP ZÜHAL,ÖZBEK HİLAL,YERDELEN Kadir Özden,YILMAZ Gülderen,KAZAZ CAVİT,DEMIREZER LUTFIYE OMUR Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. , 2017, ss.462 - 505.
AMA	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. . 2017; 462 - 505.
Vancouver	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. . 2017; 462 - 505.
IEEE	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L "Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica." , ss.462 - 505, 2017.
ISNAD	GÜVENALP, ZÜHAL vd. "Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica". (2017), 462-505.

APA	GÜVENALP Z, ÖZBEK H, YERDELEN K, YILMAZ G, KAZAZ C, DEMIREZER L (2017). Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. Records of Natural Products, 11(5), 462 - 505.
Chicago	GÜVENALP ZÜHAL,ÖZBEK HİLAL,YERDELEN Kadir Özden,YILMAZ Gülderen,KAZAZ CAVİT,DEMIREZER LUTFIYE OMUR Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. Records of Natural Products 11, no.5 (2017): 462 - 505.
MLA	GÜVENALP ZÜHAL,ÖZBEK HİLAL,YERDELEN Kadir Özden,YILMAZ Gülderen,KAZAZ CAVİT,DEMIREZER LUTFIYE OMUR Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. Records of Natural Products, vol.11, no.5, 2017, ss.462 - 505.
AMA	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. Records of Natural Products. 2017; 11(5): 462 - 505.
Vancouver	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica. Records of Natural Products. 2017; 11(5): 462 - 505.
IEEE	GÜVENALP Z,ÖZBEK H,YERDELEN K,YILMAZ G,KAZAZ C,DEMIREZER L "Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica." Records of Natural Products, 11, ss.462 - 505, 2017.
ISNAD	GÜVENALP, ZÜHAL vd. "Cholinesterase Inhibition and Molecular Docking Studies of Sesquiterpene Coumarin Ethers from Heptaptera cilicica". Records of Natural Products 11/5 (2017), 462-505.