Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey

BEŞIŞIK, Sevgi K.; BEKÖZ, HÜSEYİN S; OGUZ, Fatma S.; HINDILERDEN, Ipek Y; KIVANC, Demet; KANTARCIOĞLU, Bülent; OGRET, Yeliz D; SARGIN, Deniz

Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey

Bülent KANTARCIOĞLU, (Istanbul Medipol University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

HÜSEYİN S BEKÖZ, (Istanbul Medipol University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

Ipek Y HINDILERDEN, (Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

Demet KIVANC, (Istanbul Medipol University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

Yeliz D OGRET, (Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, TURKEY)

Sevgi K. BEŞIŞIK, (Istanbul University, Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

Fatma S. OGUZ, (Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology, Istanbul, TURKEY)

Deniz SARGIN (Istanbul Medipol University, Faculty of Medicine, Department of Internal Medicine, Division of Hematology)

Uluslararası Hematoloji-Onkoloji Dergisi

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Yıl: 2017 Cilt: 27 Sayı: 2 Sayfa Aralığı: 74 - 84 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey

Öz:

Çalışmamızda, İstanbul, Türkiye'de bulunan 2 farklı merkezde takip ettiğimiz ve HLA-A, B, C, DRB1, DQB1 ve DPB1 için tam olarak test edilmiş, 34 donör/alıcı çiftinin akraba-dışı allojeneik kök hücre nakli verileri geriye dönük olarak incelendi. En az bir antijen seviyesinde HLA-DPB1 uyumsuzluk oranı %79.6 olarak saptandı. Sadece %20.6 transplant çiftinde HLA-DPB1 tam uyumlu olduğu görüldü. Nötrofil ve trombosit engraftmanı tüm hasta grubuda başarılı bir şekilde meydana geldi. Şiddetli (Derece III-IV) aGVHH dikkate alındığında, nonpermisif HLA-DPB1 uyumsuzluklarının önemli bir faktör olduğu saptandı (p= 0.019). Nonpermisif HLA-DPB1 uyumsuzluğu bulunan nakillerde barsak (p= 0.006) ve karaciğer (p: 0.054) aGVHH'nda artış saptanırken, cilt aGVHH'da bu bulguya rastlanmadı. Çok değişkenli analizde, permisif olmayan HLA-DPB1 uyumsuzlukları şiddetli aGVHH için bağımsız bir faktör olduğu görüldü. HLA-DPB1 uyumsuzluklarının relaps üzerine anlamlı bir etkisinin olmadığı görüldü. Sağkalım analizinde, hem HLA-DPB1 uyumsuzluklarının, hem de nonpermisif uyumsuzlukların olaysız ve genel sağkalım zamanlarında azalma eğilimine neden olduğu görüldü. Donör seçimi sırasında bu sonuçların gözönüne alınması akraba-dışı allojeneik kök hücre nakli sonuçlarını iyileştirebilir

Anahtar Kelime:

Konular: Onkoloji

Akrabadişi Allojeneik Kök Hücre Naklinde Hla-Dpb1 Tayininin Önemi: Türkiye’den İki Merkezin Sonuçları

Öz:

In this study, we retrospectively examined 34 donor/recipient transplant pairs fully tested for the alleles HLA-A, B, C, DRB1, DQB1 and DPB1 in two different centers in Istanbul, Turkey. HLA-DPB1 disparity in at least one antigen level was 79.6% and only 20.6% of transplant pairs were fully identical for HLA-DPB1, in our study group. Neutrophil and thrombocyte engraftment successfully occurred in the entire study group. When the occurrence of severe (Grade III-IV) aGVHD was taken into account, we have observed that, non-permissive HLA-DPB1 mismatches were a significant factor for development of severe aGVHD (p= 0.019). There was a trend of increasing significance for the gut (p= 0.006) and liver (p: 0.054) aGVHD but not for skin aGVHD in non-permissive HLA-DPB1 mismatched transplantations. In multivariate analysis, non-permissive HLA-DPB1 mismatches remained as an independent factor for severe aGVHD. Our results did not show a significant impact of HLA-DPB1 mismatches on relapse. In survival analysis, both HLADPB1 disparities and non-permissive mismatches showed a decreasing trend of event free and overall survival times. Considering these results during donor selection may improve transplant outcomes in the setting of unrelated ASCT

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KANTARCIOĞLU B, BEKÖZ H, HINDILERDEN I, KIVANC D, OGRET Y, BEŞIŞIK S, OGUZ F, SARGIN D (2017). Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. , 74 - 84.
Chicago	KANTARCIOĞLU Bülent,BEKÖZ HÜSEYİN S,HINDILERDEN Ipek Y,KIVANC Demet,OGRET Yeliz D,BEŞIŞIK Sevgi K.,OGUZ Fatma S.,SARGIN Deniz Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. (2017): 74 - 84.
MLA	KANTARCIOĞLU Bülent,BEKÖZ HÜSEYİN S,HINDILERDEN Ipek Y,KIVANC Demet,OGRET Yeliz D,BEŞIŞIK Sevgi K.,OGUZ Fatma S.,SARGIN Deniz Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. , 2017, ss.74 - 84.
AMA	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. . 2017; 74 - 84.
Vancouver	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. . 2017; 74 - 84.
IEEE	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D "Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey." , ss.74 - 84, 2017.
ISNAD	KANTARCIOĞLU, Bülent vd. "Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey". (2017), 74-84.

APA	KANTARCIOĞLU B, BEKÖZ H, HINDILERDEN I, KIVANC D, OGRET Y, BEŞIŞIK S, OGUZ F, SARGIN D (2017). Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. Uluslararası Hematoloji-Onkoloji Dergisi, 27(2), 74 - 84.
Chicago	KANTARCIOĞLU Bülent,BEKÖZ HÜSEYİN S,HINDILERDEN Ipek Y,KIVANC Demet,OGRET Yeliz D,BEŞIŞIK Sevgi K.,OGUZ Fatma S.,SARGIN Deniz Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. Uluslararası Hematoloji-Onkoloji Dergisi 27, no.2 (2017): 74 - 84.
MLA	KANTARCIOĞLU Bülent,BEKÖZ HÜSEYİN S,HINDILERDEN Ipek Y,KIVANC Demet,OGRET Yeliz D,BEŞIŞIK Sevgi K.,OGUZ Fatma S.,SARGIN Deniz Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. Uluslararası Hematoloji-Onkoloji Dergisi, vol.27, no.2, 2017, ss.74 - 84.
AMA	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. Uluslararası Hematoloji-Onkoloji Dergisi. 2017; 27(2): 74 - 84.
Vancouver	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey. Uluslararası Hematoloji-Onkoloji Dergisi. 2017; 27(2): 74 - 84.
IEEE	KANTARCIOĞLU B,BEKÖZ H,HINDILERDEN I,KIVANC D,OGRET Y,BEŞIŞIK S,OGUZ F,SARGIN D "Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey." Uluslararası Hematoloji-Onkoloji Dergisi, 27, ss.74 - 84, 2017.
ISNAD	KANTARCIOĞLU, Bülent vd. "Impact of HLA-DPB1 Matching in Unrelated Allogeneic Stem Cell Transplantation: Results of Two Centers From Turkey". Uluslararası Hematoloji-Onkoloji Dergisi 27/2 (2017), 74-84.