TY  - JOUR
TI  - Antioxidant, Antigenotoxic, Antimicrobial Activities and Phytochemical Analysis of Dianthus carmelitarum
AB  - In this study, we investigated the phytochemical composition, antioxidant, antimicrobial, and antigenotoxic properties of the aqueous extract of Dianthus carmelitarum for the first time. The phenolic and volatile compounds, antioxidant, antimicrobial and antigenotoxic activities of the extract were determined by HPLC and SPME-GC-FID/MS, spectrophotometric, agar well diffusion methods and comet assay, respectively. The polyphenolic content and ferric reducing power values of the extract were found 12.6 ± 0.27 mg gallic acid and 238 ± 2.89 μM trolox equivalents per g sample, respectively. Syringaldehyde and chlorogenic acid were detected as major phenolic compounds, while terpenes were determined as major volatile compound. Dianthus carmelitarum extract especially exhibited moderate antimicrobial activity against Mycobacterium smegmatis. Extract reduced H2O2-induced DNA damage in a concentration dependent manner in fibroblast cells compared to positive control (only 20 μM H2O2 treatment). Dianthus carmelitarum can be considered in the food, cosmetic, and drug industries due to its antioxidant, antimicrobial, and antigenotoxic activities
AU  - Korkmaz, Nuriye
AU  - Alpay Karaoğlu, Şengül
AU  - Demir, Selim
AU  - Turgut, Sıla
AU  - badem, merve
AU  - SEYAZ, MEHTAP
AU  - ALİYAZICIOĞLU, Rezzan
AU  - ÖZGEN, Ufuk
AU  - ALİYAZICIOĞLU, Yüksel
PY  - 2017
JO  - Records of Natural Products
VL  - 11
IS  - 3
SN  - 1307-6167
SP  - 270
EP  - 284
DB  - TRDizin
UR  - http://search/yayin/detay/269668
ER  -