The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

MERT, Nihat; yildirim, Serkan; Mert, Handan; ATAMAN, Neşe

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

Neşe ATAMAN, (Hakkari University, Health Services Vocational School, Hakkar)

Handan MERT, (Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Biochemistry, Van)

Serkan YILDIRIM, (Atatürk University, Faculty of Veterinary Medicine, Department of Pathology, Erzurum, Turkey.)

Nihat MERT (Yüzüncü Yıl University, Faculty of Veterinary Medicine, Department of Biochemistry, Van)

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2018 Cilt: 65 Sayı: 1 Sayfa Aralığı: 9 - 14 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats

Öz:

Fucoidan, tüm kahverengi alglerin hücreler arası boşluklarında bulunan yüksek vizkoziteye sahip müsilajımsı, önemli oranda sülfat ester grupları ve L-fukoz içeren bir polisakkarittir. Bu çalışmada ratlarda gentamisin (GM) ile oluşturulan nefrotoksisitede fucoidan kullanılmasının bazı biyokimyasal parametreler ile böbrek dokusu üzerine etkisinin araştırılması hedeflenmiştir. Çalışmada kullanılan ratlar rastgele seçilerek her biri 7 rattan oluşan 4 gruba ayrıldı: Kontrol grubu, fucoidan grubu, GM grubu, GM+fucoidan grubu. Sekiz günlük deneme süresinden 24 saat sonra kan örnekleri alındı. Kreatinin, BUN, ürik asit, glukoz, trigliserit, total kolesterol, VLDL, HDL, total bilirubin düzeyleri ile ALT, AST, ALP, LDH, CK, amilaz aktiviteleri otoanalizörde analiz edildi. Böbrek dokuları histopatolojik açıdan incelendi. GM grubuna göre fucoidan+GM grubunda kreatinin (p<0.001), BUN (p<0.001), ürik asit (p<0.05), trigliserit (p<0.05), VLDL (p<0.05), AST (p<0.001), ALP (p<0.05), LDH (p<0.001), CK (p<0.01) düzeylerinin istatistiki olarak önemli ölçüde azaldığı, HDL (p<0.05) düzeyinin ise yükseldiği tespit edildi. Sonuç olarak; GM'le oluşturulan nefrotoksisitede incelenen biyokimyasal parametrelere ve böbrek dokusundaki histopatolojik değişimlere bakarak GM'le beraber fucoidan verilmesinin GM'nin oluşturduğu nefrotoksik hasarı zayıflattığı, fucoidanın böbreği koruyucu özelliğinin bulunduğu söylenebilir

Anahtar Kelime:

Konular: Veterinerlik

Ratlarda gentamisin ile oluşturulan nefrotoksisitede bazı biyokimyasal parametreler üzerine fucoidanın etkisi

Öz:

Fucoidan is a polysaccharide with high viscosity and mucilage, which contains significant proportion of sulphate ester group and L-fucose. It is present in intercellular spaces of brown algae. This study aimed to investigate the effect of fucoidan on some biochemical parameters and kidney tissues in nephrotoxicity induced by GM in rats. The rats used in the study were randomly divided into 4 groups. Each group had 7 rats as control, fucoidan, GM and GM+fucoidan. Blood samples were taken after 24 hours from the end of experiment which lasted eight days. Creatinine, BUN, uric acid, glucose, triglycerides, total cholesterol, VLDL, HDL, total bilirubin levels and ALT, AST, ALP, LDH, CK, amylase activities were assayed by an autoanalyser. The kidney tissues were examined histopathologically. In GM+fucoidan group, creatinine (p<0.001), BUN (p<0.001), uric acid (p<0.05), triglycerides (p<0.05), VLDL (p<0.05), AST (p<0.001), ALP (p<0.05), LDH (p<0.001), CK (p<0.01) levels statistically decreased, however HDL (p<0.05) level increased when compared to GM group. As conclusion, it can be said that administering fucoidan during GM toxicity decreases the nephrotoxicity damage. Considering biochemical parameters and histopathological findings, fucoidan can be suggested as a protective agent for kidneys in nephrotoxicity induced rats

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ATAMAN N, Mert H, yildirim S, MERT N (2018). The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. , 9 - 14.
Chicago	ATAMAN Neşe,Mert Handan,yildirim Serkan,MERT Nihat The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. (2018): 9 - 14.
MLA	ATAMAN Neşe,Mert Handan,yildirim Serkan,MERT Nihat The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. , 2018, ss.9 - 14.
AMA	ATAMAN N,Mert H,yildirim S,MERT N The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. . 2018; 9 - 14.
Vancouver	ATAMAN N,Mert H,yildirim S,MERT N The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. . 2018; 9 - 14.
IEEE	ATAMAN N,Mert H,yildirim S,MERT N "The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats." , ss.9 - 14, 2018.
ISNAD	ATAMAN, Neşe vd. "The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats". (2018), 9-14.

APA	ATAMAN N, Mert H, yildirim S, MERT N (2018). The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 65(1), 9 - 14.
Chicago	ATAMAN Neşe,Mert Handan,yildirim Serkan,MERT Nihat The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi 65, no.1 (2018): 9 - 14.
MLA	ATAMAN Neşe,Mert Handan,yildirim Serkan,MERT Nihat The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol.65, no.1, 2018, ss.9 - 14.
AMA	ATAMAN N,Mert H,yildirim S,MERT N The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2018; 65(1): 9 - 14.
Vancouver	ATAMAN N,Mert H,yildirim S,MERT N The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats. Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2018; 65(1): 9 - 14.
IEEE	ATAMAN N,Mert H,yildirim S,MERT N "The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats." Ankara Üniversitesi Veteriner Fakültesi Dergisi, 65, ss.9 - 14, 2018.
ISNAD	ATAMAN, Neşe vd. "The effect of fucoidan on changes of some biochemical parameters in nephrotoxicity induced by gentamicin in rats". Ankara Üniversitesi Veteriner Fakültesi Dergisi 65/1 (2018), 9-14.