Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak

DAĞLIOĞLU, Nebile; EFEOĞLU ÖZŞEKER, PINAR

Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak

PINAR EFEOĞLU ÖZŞEKER, (Çukurova Üniversitesi Tıp Fakültesi Adli Tıp Anabilim Dalı, Adana)

Nebile DAĞLIOĞLU (Çukurova Üniversitesi Tıp Fakültesi Adli Tıp Anabilim Dalı, Adana)

Adli Tıp Bülteni

18 2

Yıl: 2018 Cilt: 23 Sayı: 1 Sayfa Aralığı: 47 - 52 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak

Öz:

Son zamanlarda hassas ve seçici analitik tekniklerin gelişmesiyle beraber alternatif biyolojik örneklerin kullanımı artmıştır. Özellikle dekompoze ve pütrifiye olmuş postmortem vakalarda ya da kan veya idrar örneklerinin alınamadığı durumlarda saç ve tırnak gibi keratin yapılı biyolojik örnekler adli ve klinik toksikologların ilgisini çekmiştir.İlaçlar, kimyasallar, uyutucu-uyuşturucu maddeler, ağır metaller uzun dönem saçta ve tırnakta birikebilmektedir. Geçmişe dönük kullanımda iyi bir belirteç olan saç örneğinin yetersiz olduğu durumlarda toksikolojik analiz için tırnak örneği yararlı olabilmektedir. Tırnak matrisinin kompleks yapısı ve tırnakta tespit edilen ilaç konsantrasyonunun düşük olması nedeniyle numune hazırlama işlemi ve kullanılacak olan analitik yöntemler önemlidir.Bu çalışmada toksikolojik analizlerde alternatif olarak kullanılan tırnağın anatomik yapısı, tırnak analizlerindeki analitik yöntemler, tırnak kullanımın avantajları/dezavantajları ve analiz sonuçların nasıl yorumlanacağı incelenecektir.

Anahtar Kelime:

Konular: Adli Tıp Toksikoloji

An Alternative Specimen in Toxicological Analysis: Nail

Öz:

The use of alternative biological samples has increased with the development of sensitive and selective analytical techniques in recent days. Keratinous biological samples such as hair and nail have attracted the attention of clinical and forensic toxicologist when blood and urine sample especially were not taken in cases which were the decomposed and unfolded postmortem cases.Drugs, medicines, drug of abuse and heavy metals may accumulate for a long time in hair and nail. The nail sample may be useful for toxicological analysis when the hair sample, which is a good marker for past use, is inadequate. Sample preparation and analytical methods to be used are important because of the complex structure of nail and low drug concentration detected in nail.In this study, the basic structure of nail used as an alternative to toxicological analysis, the mechanism of drug or substance transfer into the nail, analytical methods, the advantages / disadvantages of nails and how to interpret the results will be examined.

Anahtar Kelime:

Konular: Adli Tıp Toksikoloji

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	EFEOĞLU ÖZŞEKER P, DAĞLIOĞLU N (2018). Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. , 47 - 52.
Chicago	EFEOĞLU ÖZŞEKER PINAR,DAĞLIOĞLU Nebile Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. (2018): 47 - 52.
MLA	EFEOĞLU ÖZŞEKER PINAR,DAĞLIOĞLU Nebile Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. , 2018, ss.47 - 52.
AMA	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. . 2018; 47 - 52.
Vancouver	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. . 2018; 47 - 52.
IEEE	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N "Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak." , ss.47 - 52, 2018.
ISNAD	EFEOĞLU ÖZŞEKER, PINAR - DAĞLIOĞLU, Nebile. "Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak". (2018), 47-52.

APA	EFEOĞLU ÖZŞEKER P, DAĞLIOĞLU N (2018). Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni, 23(1), 47 - 52.
Chicago	EFEOĞLU ÖZŞEKER PINAR,DAĞLIOĞLU Nebile Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni 23, no.1 (2018): 47 - 52.
MLA	EFEOĞLU ÖZŞEKER PINAR,DAĞLIOĞLU Nebile Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni, vol.23, no.1, 2018, ss.47 - 52.
AMA	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni. 2018; 23(1): 47 - 52.
Vancouver	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak. Adli Tıp Bülteni. 2018; 23(1): 47 - 52.
IEEE	EFEOĞLU ÖZŞEKER P,DAĞLIOĞLU N "Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak." Adli Tıp Bülteni, 23, ss.47 - 52, 2018.
ISNAD	EFEOĞLU ÖZŞEKER, PINAR - DAĞLIOĞLU, Nebile. "Adli Toksikolojik Analizlerde Alternatif Örnek: Tırnak". Adli Tıp Bülteni 23/1 (2018), 47-52.