Investigation of serum oxidative stress levels in patients with nasal polyps

EKİNCİ, ADNAN

Investigation of serum oxidative stress levels in patients with nasal polyps

Adnan EKİNCİ (Hitit University, Faculty of Medicine, Otorhinolaryngology Department, Çorum, Turkey ORCID: 0000-0001-7725-8024)

Dicle Tıp Dergisi

2 0

Yıl: 2018 Cilt: 45 Sayı: 1 Sayfa Aralığı: 1 - 7 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Investigation of serum oxidative stress levels in patients with nasal polyps

Öz:

Amaç: Nazal polip hastaları ile sağlıklı bireyler arasında serum total antioksidan status (TAS), total oksidan status (TOS) ve paraoksonaz (PON1) düzeylerini karşılaştırmak. Yöntemler: Çalışmamızda nazal polip grubunda 26 erkek, 22 kadın, toplam 48 hasta (ortalama yaş 37.11 ± 12.07 yıl), kontrol grubunda 22 erkek ve 24 kadın olmak üzere toplam 46 sağlıklı birey (ortalama yaş 36.91 ± 13.03) dahil edildi. literature because of the limited number of studies on this issue. METHODS The present study was carried out between January 15 and July 01, 2016 in Hitit University, otolaryngology department. Gaziosmanpaşa University Clinical Research Ethics Committee approved to work. (Decree No. 15, KAEK190).A total of 48 patients diagnosed with nasal polyps, and 46 healthy subjects were included in the study. There were 26 were males and 22 were females with a mean age of 38.1 years in the nasal polyp group. The control group consisted of 46 subjects, 22 males and 24 females, with a mean age of 36.9 years. All participants provided their written informed consents for participating in the study. The diagnosis of the patients was made by direct and endoscopic examinations. The nasal polyp patients with atherosclerosis, malignant tumor, hypertension, chronic inflammatory diseases, diabetes mellitus and nasal disorders such as antrochoanal polyp, inverted papilloma were excluded. The subjects in the control group did not have any systemic diseases, bronchial asthma or nasal disorders including chronic sinusitis, nasal polyps and allergy. None of the patients or controls were smokers or consumed alcohol. Serum samples were collected from patients with nasal polyps and control group before any medical or surgical treatment was applied. Ten milliliters of venous blood sample was drawn into vacuumed test tubes between 8:00 and 10:00 AM to measure TAS, TOS and PON1. After waiting for 30-45 minutes, blood was centrifuged at 4000 RPM for 10 minutes, serum was separated, and stored in an Eppendorf tube at suitable cold. Biochemical Measurements: TAS and TOS measurements developed by Erel were used for measurements.7,9 Determination of TOS was performed by a full automatic kit developed by Erel (RelAssay Diagnostics kit, Mega Tıp, Gaziantep, Turkey), which was measured.

Anahtar Kelime:

Konular: Cerrahi

Nazal Polip'li Hastalarda Serum Oksidatif Stres Düzeylerinin Araştırılması

Öz:

Objective: To compare serum total antioxidant status (TAS), total oxidant status (TOS), and paraoxonase (PON1) levels between nasal polyp patients and heal thy subjects. Method: In the present study, The nasal polyp group includes 26 males an 22 females, a total of 48 patients (mean age 37.11±12.07 years), while the control group included 22 males and 24 females, a total of 46 healthy subjects (mean age 36.91±13.03) years. Groups were compared in terms of serum TAS, TOS and PON1 levels. Results: The mean TAS level was 1.248 mmol/L in the control group, it was 1.176 mmol/L in the patient group (p=0.044). The mean TOS level was 3.443 mmol/L in the control group, and it was 6.720 mmol/L in the patient group (p=006). Nasal polyp and control groups did not show any significant difference for PON1 (301.15 U/L vs. 295.75 U/L,p>0.05). Conclusion: Serum TOS levels were significantly higher, and TAS levels were significantly lower in patients with nasal polyposis compared it the control group. There was no significant difference between the patients with nasal polypand the control group in terms of the PON1 values.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	EKİNCİ A (2018). Investigation of serum oxidative stress levels in patients with nasal polyps. , 1 - 7.
Chicago	EKİNCİ ADNAN Investigation of serum oxidative stress levels in patients with nasal polyps. (2018): 1 - 7.
MLA	EKİNCİ ADNAN Investigation of serum oxidative stress levels in patients with nasal polyps. , 2018, ss.1 - 7.
AMA	EKİNCİ A Investigation of serum oxidative stress levels in patients with nasal polyps. . 2018; 1 - 7.
Vancouver	EKİNCİ A Investigation of serum oxidative stress levels in patients with nasal polyps. . 2018; 1 - 7.
IEEE	EKİNCİ A "Investigation of serum oxidative stress levels in patients with nasal polyps." , ss.1 - 7, 2018.
ISNAD	EKİNCİ, ADNAN. "Investigation of serum oxidative stress levels in patients with nasal polyps". (2018), 1-7.

APA	EKİNCİ A (2018). Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Tıp Dergisi, 45(1), 1 - 7.
Chicago	EKİNCİ ADNAN Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Tıp Dergisi 45, no.1 (2018): 1 - 7.
MLA	EKİNCİ ADNAN Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Tıp Dergisi, vol.45, no.1, 2018, ss.1 - 7.
AMA	EKİNCİ A Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Tıp Dergisi. 2018; 45(1): 1 - 7.
Vancouver	EKİNCİ A Investigation of serum oxidative stress levels in patients with nasal polyps. Dicle Tıp Dergisi. 2018; 45(1): 1 - 7.
IEEE	EKİNCİ A "Investigation of serum oxidative stress levels in patients with nasal polyps." Dicle Tıp Dergisi, 45, ss.1 - 7, 2018.
ISNAD	EKİNCİ, ADNAN. "Investigation of serum oxidative stress levels in patients with nasal polyps". Dicle Tıp Dergisi 45/1 (2018), 1-7.