Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

ŞİRAZ, Ülkü Gül; doğan, murat; Hatipoglu, Nihal; Muhtaroğlu, Sabahattin; Kurtoğlu, Selim

Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

Ülkü Gül ŞİRAZ, (Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey)

Murat DOĞAN, (Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey)

Nihal HATİPOĞLU, (Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey)

Sabahattin MUHTAROĞLU, (Erciyes University Faculty of Medicine, Department of Biochemistry, Kayseri, Turkey)

Selim KURTOĞLU (Erciyes University Faculty of Medicine, Department of Pediatric Endocrinology, Kayseri, Turkey)

Journal of Clinical Research in Pediatric Endocrinology

1 0

Yıl: 2017 Cilt: 9 Sayı: 4 Sayfa Aralığı: 293 - 299 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?

Öz:

Objective: Metabolic impairment in type 1 diabetes mellitus (T1DM) with poor glycemic control causes insulin resistance, non-alcoholic fatty liver disease (NAFLD), atherosclerosis, and increased carotid intima-media thickness (CIMT). Fetuin-A has a protective effect in cardiovascular disorders and is increased in hepatosteatosis. We aimed to investigate the reliability of fetuin-A levels in early detection of diabetic complications in children with T1DM and to identify a cut-off value that may show poor metabolic control. Methods: The study included 80 patients who had T1DM for at least 5 years and who had no chronic complications or an auto-immune disorder. Blood samples were drawn to measure hemoglobin A1c (HbA1c), biochemical parameters, and fetuin-A levels. Anthropometric parameters were also measured. Percent body fat was calculated. Hepatosteatosis and CIMT were assessed by sonography. Results: Mean age of the patients was 13.5 years. Grade 1 hepatosteatosis was detected in 10%. Patients were stratified into 2 groups based on presence of NAFLD. Fetuin-A level was increased in patients with NAFLD. We identified a fetuin-A cut-off value (514.28 ng/mL; sensitivity: 47.34; specificity: 96.72) that may predict NAFLD. HbA1c and total cholesterol levels were found to be higher in patients with fetuin-A levels above higher the cut-off value.Conclusion: Fetuin-A is a reliable parameter in the prediction of complications and poor glycemic control in patients with T1DM.

Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Pediatri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

TRDizin Dışındaki Atıf Sayıları

OpenCitations: 0

OpenAlex: 0

Crossref: 0

Bacha F, Klinepeter Bartz S. Insulin resistance, role of metformin and other non-insulin therapies in pediatric type 1 diabetes. Pediatr Diabetes 2016;17:545-558. Epub 2015 Nov 23
Vergès B. Lipid disorders in type 1 diabetes. Diabetes Metab 2009;35:353-360. Epub 2009 Sep 4
Im SS, Kang SY, Kim SY, Kim HI, Kim JW, Kim KS, Ahn YH. Glucose- stimulated upregulation of GLUT2 gene is mediated by sterol response element-binding protein-1c in the hepatocytes. Diabetes 2005;54:1684- 1691.
Pacifico L, Nobili V, Anania C, Verdecchia P, Chiesa C. Pediatric nonalcoholic fatty liver disease, metabolic syndrome and cardiovascular risk. World J Gastroenterol 2011;17:3082-3091.
Viswanathan V. Preventing microvascular complications in type 1 diabetes mellitus. Indian J Endocrinol Metab 2015;19(Suppl 1):36-38.
Najafian B, Mauer M. Progression of diabetic nephropathy in type 1 diabetic patients. Diabetes Res Clin Pract 2009;83:1-8. Epub 2008 Dec 12
Fathi R, Marwick TH. Noninvasive tests of vascular function and structure: why and how to perform them. Am Heart J 2001;141:694- 703.
Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Pichiri I, Sorgato C, Zenari L, Bonora E. Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type 1 diabetes. J Hepatol 2010;53:713-718.
Mathews ST, Rakhade S, Zhou X, Parker GC, Coscina DV, Grunberger G. Fetuin-null mice are protected against obesity and insulin resistance associated with aging. Biochem Biophys Res Commun 2006;350:437- 443. Epub 2006 Sep 25
Takata H, Ikeda Y, Suehiro T, Ishibashi A, Inoue M, Kumon Y, Terada Y. High glucose induces transactivation of the alpha2-HS glycoprotein gene through the ERK1/2 signaling pathway. J Atheroscler Thromb 2009;16:448-456. Epub 2009 Aug 11
Senol V, Unalan D, Bayat M, Mazicioglu MM, Ozturk A, Kurtoglu S. Change in reference body mass index percentiles and deviation in overweight and obesity over 3 years in Turkish children and adolescents. J Pediatr Endocrinol Metab 2014;27:1121-1129.
Mazıcıoğlu MM, Hatipoğlu N, Oztürk A, Ciçek B, Ustünbaş HB, Kurtoğlu S. Waist circumference and mid-upper arm circumference in evaluation of obesity in children aged between 6 and 17 years. J Clin Res Pediatr Endocrinol 2010;2:144-150. Epub 2010 Dec 10
Mazicioglu MM, Kurtoglu S, Ozturk A, Hatipoglu N, Cicek B, Ustunbas HB. Percentiles and mean values for neck circumference in Turkish children aged 6-18 years. Acta Paediatr 2010;99:1847-1853.
Smith ER, Ford ML, Tomlinson LA, Rocks BF, Rajkumar C, Holt SG. Poor agreement between commercial ELISAs for plasma fetuin-A: An effect of protein glycosylation? Clin Chim Acta 2010;411:1367-1370. Epub 2010 Apr 24
Rosenbloom A, Silverstein J. Diabetes in the child and adolescent. in: Lifshitz F (ed). Pediatric Endocrinology. 4th ed. New York, Marcel Dekker, 2004; p. 611-651.
El-Karaksy HM, Anwar G, Esmat G, Mansour S, Sabry M, Helmy H, El- Hennawy A, Fouad H. Prevalence of hepatic abnormalities in a cohort of Egyptian children with type 1 diabetes mellitus. Pediatric Diabetes 2010;11:462-470.
Mansoor S, Yerian L, Kohli R, Xanthakos S, Angulo P, Ling S, Lopez R, Christine CK, Feldstein AE, Alkhouri N. The evaluation of hepatic fibrosis scores in children with nonalcoholic fatty liver disease. Dig Dis Sci 2015;60:1440-1447. Epub 2014 Dec 25
Yang HR, Kim HR, Kim MJ, Ko JS, Seo JK. Noninvasive parameters and hepatic fibrosis scores in children with nonalcoholic fatty liver disease. World J Gastroenterol 2012;18:1525-1530.
Kummer S, Klee D, Kircheis G, Friedt M, Schaper J, Häussinger D, Mayatepek E, Meissner T. Screening for non-alcoholic fatty liver disease in children and adolescents with type 1 diabetes mellitus: a cross-sectional analysis. Eur J Pediatr 2017;176:529-536. Epub 2017 Feb 17
Gökşen D, Levent E, Kar S, Ozen S, Darcan S. Serum adiponectin and hsCRP levels and non-invasive radiological methods in the early diagnosis of cardiovascular system complications in children and adolescents with type 1 diabetes mellitus. J Clin Res Pediatr Endocrinol 2013;5:174-181.
Çiftel M, Ertuğ H, Parlak M, Akçurin G, Kardelen F Investigation of endothelial dysfunction and arterial stiffness in children with type 1 diabetes mellitus and the association with diastolic dysfunction. Diab Vasc Dis Res 2014;11:19-25. Epub 2013 Oct 29
Dasgupta S, Bhattacharya S, Biswas A, Majumdar SS, Mukhopadhyay S, Ray S, Bhattacharya S. NF-kappaB mediates lipid-induced fetuin-A expression in hepatocytes that impairs adipocyte function effecting insulin resistance. Biochem J 2010;429:451-462.
Ix JH, Shlipak MG, Brandenburg VM, Ali S, Ketteler M, Whooley MA. Association between human fetuin-A and the metabolic syndrome: data from the Heart and Soul Study. Circulation 2006;113:1760-1767. Epub 2006 Mar 27
Jelenik T, Séquaris G, Kaul K, Ouwens DM Phielix E, Kotzka J, Knebel B, Weiß J, Reinbeck AL, Janke L, Nowotny P, Partke HJ, Zhang D, Shulman GI, Szendroedi J, Roden M. Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes. Diabetes 2014;63:3856-3867. Epub 2014 Jun 10
Gheissari A, Javanmard SH, Shirzadi R, Amini M, Khalili N. Lowering effect of valsartan on fetuin-A in type 1 diabetes mellitus. Iran J Kidney Dis 2013;7:440-445.
Abd El Dayem SM, Battah AA, El Bohy Ael M, El Shehaby A. Evaluation of fetuin-A and carotid intima-media thickness in adolescent type 1 diabetic patients. J Pediatr Endocrinol Metab 2015;28:287-292.

APA	ŞİRAZ Ü, doğan m, Hatipoglu N, Muhtaroğlu S, Kurtoğlu S (2017). Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. , 293 - 299.
Chicago	ŞİRAZ Ülkü Gül,doğan murat,Hatipoglu Nihal,Muhtaroğlu Sabahattin,Kurtoğlu Selim Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. (2017): 293 - 299.
MLA	ŞİRAZ Ülkü Gül,doğan murat,Hatipoglu Nihal,Muhtaroğlu Sabahattin,Kurtoğlu Selim Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. , 2017, ss.293 - 299.
AMA	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. . 2017; 293 - 299.
Vancouver	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. . 2017; 293 - 299.
IEEE	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S "Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?." , ss.293 - 299, 2017.
ISNAD	ŞİRAZ, Ülkü Gül vd. "Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?". (2017), 293-299.

APA	ŞİRAZ Ü, doğan m, Hatipoglu N, Muhtaroğlu S, Kurtoğlu S (2017). Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. Journal of Clinical Research in Pediatric Endocrinology, 9(4), 293 - 299.
Chicago	ŞİRAZ Ülkü Gül,doğan murat,Hatipoglu Nihal,Muhtaroğlu Sabahattin,Kurtoğlu Selim Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. Journal of Clinical Research in Pediatric Endocrinology 9, no.4 (2017): 293 - 299.
MLA	ŞİRAZ Ülkü Gül,doğan murat,Hatipoglu Nihal,Muhtaroğlu Sabahattin,Kurtoğlu Selim Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. Journal of Clinical Research in Pediatric Endocrinology, vol.9, no.4, 2017, ss.293 - 299.
AMA	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(4): 293 - 299.
Vancouver	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?. Journal of Clinical Research in Pediatric Endocrinology. 2017; 9(4): 293 - 299.
IEEE	ŞİRAZ Ü,doğan m,Hatipoglu N,Muhtaroğlu S,Kurtoğlu S "Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?." Journal of Clinical Research in Pediatric Endocrinology, 9, ss.293 - 299, 2017.
ISNAD	ŞİRAZ, Ülkü Gül vd. "Can Fetuin-A Be a Marker for Insulin Resistance and Poor Glycemic Control in Children with Type 1 Diabetes Mellitus?". Journal of Clinical Research in Pediatric Endocrinology 9/4 (2017), 293-299.