THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE

ÖZTÜRK, Melike; ORBAK, RECEP

THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE

Recep ORBAK, (Atatürk Üniversitesi Diş Hekimliği Fakültesi)

Melike ÖZTÜRK (Atatürk Üniversitesi Diş Hekimliği Fakültesi)

Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi

3 0

Yıl: 2015 Cilt: 25 Sayı: 2 Sayfa Aralığı: 243 - 248 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE

Öz:

Alzheimer hastalığı yaşlı insanları etkileyennörodejeneratif bir hastalıktır. Bireyin yaşı arttıkça,Alzheimer hastalığının prevalansı da artmaktadır.Alzheimer hastalığında görüldüğü gibi, periodontalhastalık da yaşlı bireylerde daha çok görülmektedir.Periodontal hastalık kardiovasküler hastalıklar, diyabet,romatoid artrit ve erken doğum gibi sistemikhastalıklarla bağlantılıdır. Son zamanlarda, periodontalhastalığın Alzheimer hastalığıyla ilişkisinin olupolmadığı araştırılmaktadır. Bu derlemenin amacı,literatür bilgileri ışığında periodontal hastalığınAlzheimer hastalığına neden olup olmadığınıincelemektir.

Anahtar Kelime:

Konular: Diş Hekimliği

PERİODONTAL HASTALIKLA ALZHEİMER HASTALIĞI ARASINDAKİ İLİŞKİ

Öz:

Alzheimer’s disease(AD) is a neurodegenerative disease that effects elder people. As the age increases, the prevalance of Alzheimer’s disease also raises. As AD, periodontitis is seen more often in elder people. Periodontal disease has been associated with some systemical diseases such as cardiovascular diasease(CVS), diabetes mellitus, rheumatoid arthritis and preterm birth. Latterly, it has been investigated if there is a connection between Alzheimer’s diasease. This review’s aim is, inspecting if the periodontal disease contributes to Alzheimer’s disease at literacy

Anahtar Kelime:

Konular: Diş Hekimliği

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Darveau R, Tanner A, Page RC. The microbial challenge in periodontitis. Periodontol 2000 2000;14:1:12-32.
2. Lamster IB, Novak MJ. Host mediators in gingival crevicular fluid: implications for the pathogenesis of periodontal disease. Crit Rev Oral Biol Med 1992;3:1:31-60.
3. Van Dyke, TE, Kornman KS. Inflammation and factors that may regulate inflammatory response. J. Periodontol 2008;79:8:1503–7.
4. Page RC, Offenbacher S, Schroeder HE. Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions. Periodontol 2000 1997;14:1:216-48.
5. Page RC. The role of inflammatory mediators in the pathogenesis of periodontal disease. J Periodontal Res 1991;26:3:230-42.
6. Gamonal J, Acevedo A, Bascones A, Jorge O, Silva A. Levels of interleukin-1β,-8, and-10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment. Journal of periodontology2000;71:10:1535-45.
7. Tüter G,Kurtis B,Serdar M.Evaluation of gingival crevicular fluid and serum levels of high-sensitivity C-Reactive protein in chronic periodontits patients with or without coronary artery disease.J Periodontol 2007;78:12:2319-24.
8. Noack B,Genco RJ,Trevisan M,Grossi S,Zambon JJ,Nardin E.Periodontal infections contribute to elevated systemic C-reactive protein level.J Periodontol 2000 2001;72,1221-7.
9. Genco R,Offenbacher S, Beck J.Periodontal disease and cardiovascular disease. JADA 2002;133,145- 225.
10. Loos BG. Systemic markers of inflammation in periodontitis. J Periodontol 2005, 76:2106–15.
11. Forner L, Larsen T, Kilian M. Incidence of bacteremia after chewing, tooth brushing, and scaling in individuals with periodonta inflammation. J Clin Periodontol 2006;33:6:401–7.
12. Li X, Kolltveit KM, Tronstad L. Systemic diseases caused by oral infection. Clin Microbiol Rev 2000; 13:4:547–58.
13. Grau AJ, Becher H, Ziegler CM, Lichy C, Buggle F, Kaiser C. Periodontal disease as a risk factor for ischemic stroke. Stroke 2004;35:2:496–501.
14. Grossi Sara G, Robert J Genco. Periodontal Disease and Diabetes Mellitus: A Two-Way Relationship. Annals of periodontology 1998;3:1: 51-61.
15. Lopez NJ, Smith PC, Gutierrez J. Higher risk of preterm birth and low birth weight in women with periodontal disease. J Dent Res 2002; 81:1:58–63.
16. Offenbacher S, Katz V, Fertik G,Collins J,Boyd D,Maynor G,McKaig R,Beck J.Periodontal infection as a possible risk factor for preterm low birth weight.Periodontol 2000 1996;67:10:1103-13.
17. Kuran M, Arpak N, Ünsal E, Erdoğan MF.The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. J Clin Periodontol 2005;32:266-72.
18. Rosenstein E.D,Greenwald R.A,Kushner L.J,Weissmann G.Hypothesis:The humoral immune response to oral bacteria provides a stimulus fort he development of rheumatoid arthritis. Inflammation 2004;28:6:311-8.
19. Alzheimer A. Uber eine eigenartige Erkrankung der Hirnrinde. Allg Z Psychiat ui Grenzbeg 1907; 64:164-8.
20. Friedlander AH, Norman DC, Mahler ME, Norman KM, Yagiela JA. Alzheimer’s disease: psychopathology, medical management and dental implications. J Am Dent Assoc 2006;137:1240-51.
21. Kocaelli H, Yaltirik M, Yargic LI, Ozbas H. Alzheimer’s disease and dental management. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:521-4.
22. Larson EB, Shadlen MF, Wang L, et al. Survival after initial diagnosis of Alzheimer’s disease. Ann Intern Med 2004;140:501-9.
23. Folstein MF, Folstein SE, McHugh PR.―Mini-mental state― A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12:189-98.
24. Berg L. Clinical Demential Rating (CDR). Psychopharmacol Bull 1988; 24:637-9.
25. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 1993; 43:2412-4.
26. Reiman EM, Caselli RJ. Alzheimer’s disease. Maturitas 1999;15:185-200.
27. Ghezzi EM, Ship JA. Dementia and oral health. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2000; 89:1:2-5.
28. Machado DS, FRANK J,Abdala A, De Abreu Soares E. Fatores dietéticos relacionados à doença de Alzheimer.Publicação Oficial da Sociedade Brasileira de Nutrição Parenteral e Enteral (SBNPE) e da Federación Latinoamericana de Nutrición Parenteral y Enteral (FELANPE) 2006;4005:3:252- 7.
29. Perry G, Cash AD, Smith MA. Alzheimer’s disease and oxidative stress. J Biomed Biotechnol. 2002;2:120-3.
30. Perry G, Taddeo MA, Nunomura A. Comparative biology and pathology of oxidative stress in Alzheimer’s and other neurodegenerative diseases: beyond damage and response. Comp Biochem Physiol C Toxicol Pharmacol 2002;133:507-13.
31. Lorenzo A, Yankner BA. Beta-anyloid Neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 1994;91:12243-7.
32. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994;91:10771-8.
33. Yatin SM, Varadarajan S, Link CD, et al. In vitro and in vivo oxidative stress associated with Alzheimer’s amyloid beta-peptide (1-42). Neurobiol Aging. 1999;20:325-330; discussion 339-42.
34. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer’s disease. Neuron 2004;44:1:181-93.
35. Barger SW, Harmon AD. Microglial activation by Alzheimer amyloid precursor protein and modulation by apolipoprotein E. Nature 1997; 388: 6645:878-81.
36. Dickson DW, Lee SC, Mattiace LA, et al. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer’s disease. Glia 1993; 7:75-83.
37. Cummings JL. Alzheimer’s disease. N Engl J Med 2004; 351:56-67.
38. Montenegro FLB, Marchini L, Brunetti RF, Manetta CE. A importância do bom funcionamento do sistema mastigatório para o processo digestivo dos idosos. Rev Kairós 2007;10:245-57.
39. Henry RG, Wekstein DR. Providing dental care for patients diagnosed with Alzheimer’s disease. Dent Clin North Am 1997;41:915-43.
40. Rodrigues Riberio G, Costa Riani JL, Bovi Ambrosaro GM, Rodirgues Garcia RCM. Oral health of the elderly with Alzheimer’s disease.Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:338-43.
41. Akiyama H, Arai T, Kondo H, Tanno E, Haga C, Ikeda K. Cell mediators of inflammation in the Alzheimer disease brain. Alzheimer Dis. Assoc. Disord 2000; 14: 47–53.
42. McGeer PL, Rogers J, McGeer EG. Inflammation, anti-inflammatory agents and Alzheimer disease: the last 12 years. J. Alzheimers Dis 2006;9:271–6.
43. Miklossy J. Alzheimer's disease—a spirochetosis? Neuroreport 1993;4: 1069.
44. Stein PS,Steffen MJ,Smith C,Jicha G,Ebersole JL,Abner E,Dawson D.Serum antibodies to periodontal pathogens are a risk factor for Alzheimer’s disease.Alzheimer’s&Dementia 2012; 8,196-203.
45. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, et al. Systemic inflammation and disease progression in Alzheimer’s disease. Neurology 2009;73:768–74.
46. Noble JM, Borrell LN, Papapanou PN, Elkind MSV, Scarmeas Wright CB. Periodontitis is associated with cognitive impairment among older adults: analysis of NHANES –III. J Neurol Neurosurg Psychiatry 2009;80:1206–11.
47. Bretz WA,Weyant RJ,Corby PM,Ren D, Weissfeld L,Kritchevsky SB,Harris T,Kurella M,Satterfield S,Visser M,Newman AB.Systemic inflammatory markers,periodontal disease, and periodontal infections in an elderly population.J Am Geritr Soc 2005; 53:1532-7.
48. Bo RD,Angeretti N,Lucca E,Simoni MGD,Forloni G.Reciprocal control of inflammatory cytokines, IL- 1 and IL-6, and β-amyloid productions in cultures.Neuroscience Letters 1995;188:1:70-4.
49. Leenstra TS, van Saene JJ, van Saene HK, Martin MV. Oral endotoxin in healthy adults. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 1996;82:6:637-43.
50. Loos BG, Craandijk J, Hoek FJ, Dillen PMW, Velden UVD. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. Journal of periodontology 2000;71:10:1528-34.
51. Gardiner SS. Actinomycosis of the head and neck. Australian and New Zealand Journal of Surgery 1936;6:2:186-224.
52. Gendron R, Grenier D, Maheu-Robert LF. The oral cavity as a reservoir of bacterial pathogens for focal infections. Microbes and infection 2000; 2:8:897-906.
53. Stein PS, Scheff S, Dawson DR. Alzheimer’s disease and periodontal disease: mechanisms underlying a potential bidirectional relationship. Grand Rounds Oral-Sys Med 2006;1:3:14-24.
54. Laflamme N,Rivest S. Toll-like receptor 4:the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components. The FASEB Journal 2001; 15:1:155-63.
55. Holmes C,Cotterell D. Role of infection in the pathogenesis of Alzhemer’s disease. CNS Drugs 2009;23:12:993-1002.
56. Balin BJ,Gerard HC, Arking EJ, Appelt DM, Branigan PJ, Abrams JT, Whittum-Hudson JA, Hudson AP. Identification and localization of Chlamydia pneumoniae in the Alzheimer’s brain. Med Microbiol Immunol 1998;187:1:23-42.
57. Riviere GR, Riviere KH, Smith KS. Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral microbiology and immunology 2002; 17:2:113-8.
58. Kamer AR,Craig RG,Dasanayake AP,Brys M,Glodzik-Sobanska L,Leon MJD.Inflammation and Alzheimer’s disease: possible role of periodontal disease.Alzheimer’s&Dementia 2008;4,242-50.

APA	ORBAK R, ÖZTÜRK M (2015). THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. , 243 - 248.
Chicago	ORBAK RECEP,ÖZTÜRK Melike THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. (2015): 243 - 248.
MLA	ORBAK RECEP,ÖZTÜRK Melike THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. , 2015, ss.243 - 248.
AMA	ORBAK R,ÖZTÜRK M THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. . 2015; 243 - 248.
Vancouver	ORBAK R,ÖZTÜRK M THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. . 2015; 243 - 248.
IEEE	ORBAK R,ÖZTÜRK M "THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE." , ss.243 - 248, 2015.
ISNAD	ORBAK, RECEP - ÖZTÜRK, Melike. "THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE". (2015), 243-248.

APA	ORBAK R, ÖZTÜRK M (2015). THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 25(2), 243 - 248.
Chicago	ORBAK RECEP,ÖZTÜRK Melike THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 25, no.2 (2015): 243 - 248.
MLA	ORBAK RECEP,ÖZTÜRK Melike THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, vol.25, no.2, 2015, ss.243 - 248.
AMA	ORBAK R,ÖZTÜRK M THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2015; 25(2): 243 - 248.
Vancouver	ORBAK R,ÖZTÜRK M THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE. Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi. 2015; 25(2): 243 - 248.
IEEE	ORBAK R,ÖZTÜRK M "THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE." Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi, 25, ss.243 - 248, 2015.
ISNAD	ORBAK, RECEP - ÖZTÜRK, Melike. "THE RELATIONSHIP BETWEEN PERIODONTAL DISEASE AND ALZHEIMER’S DISEASE". Atatürk Üniversitesi Diş Hekimliği Fakültesi Dergisi 25/2 (2015), 243-248.