Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

ÜNAL, Sefa; BALCI, KEVSER; topaloglu, serkan; BALCI, Mustafa Mücahit; YAYLA, ÇAĞRI; ertem, Ahmet; Akboga, Mehmet Kadri; Aras, Dursun; AYDIN, Selahattin; YILMAZ, Samet; BALBAY, YÜCEL

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Mehmet Kadri AKBOĞA, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Kevser Gülcihan BALCI, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Samet YILMAZ, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Selahattin AYDIN, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Çağrı YAYLA, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Ahmet Göktuğ ERTEM, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Sefa ÜNAL, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Mustafa Mücahit BALCI, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Yücel BALBAY, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Dursun ARAS, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Serkan TOPALOĞLU, (Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey)

Diğer Yazarlar

The Anatolian Journal of Cardiology

5 2

Yıl: 2017 Cilt: 18 Sayı: 1 Sayfa Aralığı: 48 - 53 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Öz:

Objective: Hypertrophic cardiomyopathy (HCM) as a common genetic heart disease characterized by ventricular hypertrophy and myocardial fibrosis is significantly associated with a higher risk of fatal ventricular arrhythmic events (VAEs). We aimed to assess the interval between the peak and the end of the electrocardiographic T wave (Tp–e) and Tp–e/corrected QT (QTc) ratio as candidate markers of ventricular arrhythmias in patients with HCM.Methods: In this single-center, prospective study, a total of 66 patients with HCM and 88 controls were enrolled. The patients were divided into two groups: those with VAEs (n=26) and those without VAEs (n=40). Tp–e interval and Tp–e/QTc ratio were measured using a 12-lead electrocardiogram.Results: Tp–e interval was significantly longer and Tp–e/QTc ratio were significantly higher in HCM patients than in the controls. In correlation analysis, maximal left ventricular (LV) thickness also has a significant positive correlation with Tp–e interval (r=0.422, p<0.001) and Tp–e/QTc ratio (r=0.348, p<0.001). Finally, multivariable regression analysis showed that a history of syncope, Tp–e interval [OR (odds ratio): 1.060; 95% confidence interval (CI): 1.005–1.117); p=0.012], Tp–e/QTc ratio (OR: 1.148; 95% CI: 1.086–1.204); p=0.049], and maximal LV thickness were independent predictors of VAEs in patients with HCM.Conclusion: Our findings suggested that prolonged Tp–e interval and increased Tp–e/QTc ratio may be good surrogate markers for the prediction of VAEs in HCM

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Akboga M, BALCI K, YILMAZ S, AYDIN S, YAYLA Ç, ertem A, ÜNAL S, BALCI M, BALBAY Y, Aras D, topaloglu s (2017). Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. , 48 - 53.
Chicago	Akboga Mehmet Kadri,BALCI KEVSER,YILMAZ Samet,AYDIN Selahattin,YAYLA ÇAĞRI,ertem Ahmet,ÜNAL Sefa,BALCI Mustafa Mücahit,BALBAY YÜCEL,Aras Dursun,topaloglu serkan Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. (2017): 48 - 53.
MLA	Akboga Mehmet Kadri,BALCI KEVSER,YILMAZ Samet,AYDIN Selahattin,YAYLA ÇAĞRI,ertem Ahmet,ÜNAL Sefa,BALCI Mustafa Mücahit,BALBAY YÜCEL,Aras Dursun,topaloglu serkan Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. , 2017, ss.48 - 53.
AMA	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. . 2017; 48 - 53.
Vancouver	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. . 2017; 48 - 53.
IEEE	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s "Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy." , ss.48 - 53, 2017.
ISNAD	Akboga, Mehmet Kadri vd. "Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy". (2017), 48-53.

APA	Akboga M, BALCI K, YILMAZ S, AYDIN S, YAYLA Ç, ertem A, ÜNAL S, BALCI M, BALBAY Y, Aras D, topaloglu s (2017). Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. The Anatolian Journal of Cardiology, 18(1), 48 - 53.
Chicago	Akboga Mehmet Kadri,BALCI KEVSER,YILMAZ Samet,AYDIN Selahattin,YAYLA ÇAĞRI,ertem Ahmet,ÜNAL Sefa,BALCI Mustafa Mücahit,BALBAY YÜCEL,Aras Dursun,topaloglu serkan Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. The Anatolian Journal of Cardiology 18, no.1 (2017): 48 - 53.
MLA	Akboga Mehmet Kadri,BALCI KEVSER,YILMAZ Samet,AYDIN Selahattin,YAYLA ÇAĞRI,ertem Ahmet,ÜNAL Sefa,BALCI Mustafa Mücahit,BALBAY YÜCEL,Aras Dursun,topaloglu serkan Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. The Anatolian Journal of Cardiology, vol.18, no.1, 2017, ss.48 - 53.
AMA	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. The Anatolian Journal of Cardiology. 2017; 18(1): 48 - 53.
Vancouver	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy. The Anatolian Journal of Cardiology. 2017; 18(1): 48 - 53.
IEEE	Akboga M,BALCI K,YILMAZ S,AYDIN S,YAYLA Ç,ertem A,ÜNAL S,BALCI M,BALBAY Y,Aras D,topaloglu s "Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy." The Anatolian Journal of Cardiology, 18, ss.48 - 53, 2017.
ISNAD	Akboga, Mehmet Kadri vd. "Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy". The Anatolian Journal of Cardiology 18/1 (2017), 48-53.