Turkey is a country which acquired a significant part of their income from farming and animal husbandry. Orf is a frequent disease all over the world, in areas where sheep and goat are raising. Complications due to orf are rare. Erythema multiforme is one of the complications of orf. A total of ten patients with lesions of erythema multiforme following orf were existed. Eight of the patients were female and two were male. All of the patients were living in rural areas and occupied with animal husbandry. The mean age of the patients was 34.3 years and ages of the patients ranged from 17 to 63. The mean time for the formation of orf lesions was 11.4 (range 7-20) days, while the mean time passed for erythema multiforme development was 6.7 (range 5-9) days. In terms of orf position; in two of our patients there was localization on the left side whereas in the remaining patients, localization was found on the right side. Topical corticosteroids, systemic antibiotherapy and systemic corticosteroid therapy were planned to patients as a treatment. The results of this study show that orf-related erythema multiforme occurs more frequently than we thought. Patients referred to us with a complaint of erythema multiforme following orf infection. Awareness of the public and physicians will provide a better understanding of the relationship between orf and erythema multiforme.