TY  - JOUR
TI  - The Efficacy of Alone or Combined Treatment of Aglepristone and Cabergoline on Termination of Mid-term Pregnancy in Cats
AB  - This study determined the efficacy of a combination of aglepristone and cabergoline on termination of mid-term cat pregnancies. Twenty cats withunwanted pregnancies between 30-40 days were included in the study. Aglepristone (10 mg/kg, sc) was given to the AGL group (n=6) twice in a24-h interval. Cabergoline (5 μg/kg, peros) was administered to the CBG group (n=7) once daily until abortion started or for 8 days. AGL+CBG (n=7)received a combined treatment with both drugs. Abortion occurred in 50% of cats in the AGL group, 71.4% in the CBG group, and 100% in theAGL+CBG. However, the completion of pregnancy termination rate was 85.7% because of fetal retention in one cat from the AGL+CBG group.The interval between treatment-start of abortion (T-SA) was shorter in the AGL+CBG group (3.6±0.3 days) than in the AGL (6.5±0.0) and CBG(6.2±0.2) groups (P<0.01). Similarly, the interval between treatment-end of abortion (T-EA) was shorter in the combined group (4.3±0.5 days) thanthe others (7.3±0.3 and 6.9±0.9 days, respectively) (P<0.01). Decreasing in progesterone concentration was non-significant in the AGL group fromthe start of treatment to abortion completion day (dA/d8), but significant in the others (P<0.001). On dA/d8, it was significantly lower in the CBGgroup (P<0.01) and combined group (P<0.01) than in the AGL group. Only slight diarrhea was observed in 15.4% of the AGL+CBG group. In conclusion,the AGL+CBG combination increased the rate of abortion induction and significantly shortened T-SA and T-EA with negligible side effects.
AU  - FINDIK, Murat
AU  - AY, Serhan Serhat
AU  - ÖNYAY, Firdevs
AU  - Aslan, Selim
AU  - Saral, Gülşah
AU  - Kaya, Duygu
DO  - 10.9775/kvfd.2018.19416
PY  - 2018
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 24
IS  - 4
SN  - 1300-6045
SP  - 491
EP  - 496
DB  - TRDizin
UR  - http://search/yayin/detay/288052
ER  -