TY  - JOUR
TI  - Comparison of Oxidative/Nitrosative Stress, Leptin and Progesterone Concentrations in Pregnant and Non-pregnant Abaza Goats Synchronized with Controlled Internal Drug Release Application
AB  - The aim of this study was to determine the oxidative/nitrosative stress, leptin and progesterone concentrations in pregnant and non-pregnantAbaza goats after synchronization with controlled internal drug release (CIDR) during the breeding season. For this purpose, 40 clinicallyhealthy Abaza goats, aged 2-4 years, were intravaginally exposed to CIDR on day 0, and injected with equine chorionic gonadotropin andprostaglandin F2α on day 9 of the experiment. CIDR was removed on day 11. At the end of the experiment, they were monitored for estrusand exposed to fertile males for mating. Blood samples were collected 8 days before synchronization, then on days 0, 11 of CIDR insertionand on mating day. A pregnancy diagnosis was conducted using transrectal ultrasonography 30 day after mating. The blood serum from 40goats (30 pregnant + 10 non-pregnant) was used for biochemical analyses. Malondialdehyde (MDA), nitric oxide (NO), total oxidant capacity(TOC), total antioxidant capacity (TAC) and endothelial NO synthase (eNOS) activities were significantly higher on mating day in pregnantgoats compared to non-pregnant goats (P<0.05). The eNOS activity and TOC concentrations were significantly higher on day 11 in pregnantgoats compared to non-pregnant goats (P<0.001). Serum P4 concentration increased in pregnant group on day 11 and decreased all groupson mating day than day -8, day 0 and day 11 (P<0.001). In conclusion, the administration of CIDR to Abaza goats exacerbated oxidative andnitrosative stress.
AU  - KURU, Mushap
AU  - ÖĞÜN, Metin
AU  - ORAL, Hasan
AU  - KÜKÜRT, ABDULSAMED
AU  - KULAKSIZ, Recai
DO  - 10.9775/kvfd.2018.20222
PY  - 2018
JO  - Kafkas Üniversitesi Veteriner Fakültesi Dergisi
VL  - 24
IS  - 6
SN  - 1300-6045
SP  - 887
EP  - 892
DB  - TRDizin
UR  - http://search/yayin/detay/288179
ER  -