Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Volkan, Burcu; Fettah, Ali; KURT, Nezahat; Cayir, Atilla; Islek, Ali; KARA, Soner SERTAN

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Burcu VOLKAN, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Çocuk Gastroenteroloji Anabilim Dalı, Erzurum, Türkiye)

Ali FETTAH, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Erzurum, Türkiye)

Ali İŞLEK, (Atatürk Üniversitesi, Tıp Fakültesi, Çocuk Gastroenteroloji Hepatoloji ve Beslenme Anabilim Dalı, Erzurum, Türkiye)

Soner Sertan KARA, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Erzurum, Türkiye)

Nezahat KURT, (Atatürk Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Atilla ÇAYIR (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Çocuk Endokrinoloji Bölümü, Erzurum, Türkiye)

Turkish Journal of Gastroenterology

2 1

Yıl: 2018 Cilt: 29 Sayı: 2 Sayfa Aralığı: 215 - 220 Metin Dili: İngilizce İndeks Tarihi: 19-12-2018

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

Öz:

Background/Aims: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association be-tween vitamin K levels and osteoporosis.Materials and Methods: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects.Results: Overall, 72 patients (mean age 11.69±3 years, 59.7% female) and 30 healthy subjects (mean age 12.27±2.12 years, 63.3% female) were enrolled. The mean BMD Z score of the celiac group was significantly lower than that of the control group (-1.23±1.07 vs. -0.35±1.04, p=0.001). Vitamin D and K2 values did not differ significantly between the two groups (p>0.05). BMD was positively correlat-ed with vitamin D (r=0.198, p=0.001) and negatively with PTH (r=−0.397, p=0.002).Conclusion: The BMD of celiac patients was lower than that of the control subjects. There was no difference in terms of vitamin D and K2 levels between the two groups. Further studies investigating the level and effect of vitamin K on bone in CD are needed.

Anahtar Kelime:

Konular: Gastroenteroloji ve Hepatoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

30. Valdimarsson T, Toss G, Lofman O, Ström M. Three years’ fol-low-up of bone density in adult coeliac disease: significance of sec-ondary hyperparathyroidism. Scand J Gastroenterol 2000; 35: 274-80
29. Selby PL, Davies M, Adams JE, Mawer EB. Bone loss in celiac dis-ease is related to secondary hyperparathyroidism. J Bone Miner Res 1999; 14: 652-7. [CrossRef]
28. Karagüzel G, Dilber B, Çan G, Ökten A, Değer O, Holick MF. Sea-sonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. J Pediatr Gastroenterol Nutr 2014; 58: 654-60. [CrossRef]
27. Mager DR, Qiao J, Turner J. Vitamin D and K status influences bone mineral density and bone accrual in children and adolescents with celiac disease. Eur J Clin Nutr 2012; 66: 488-95. [CrossRef]
26. van Summeren MJ, Braam LA, Lilien MR, Schurgers LJ, Kuis W, Vermeer C. The effect of menaquinone-7 (vitamin K2) supplemen-tation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr 2009; 102: 1171-8. [CrossRef]
25. Nicolaidou P, Stavrinadis I, Loukou I, et al. The effect of vitamin K supplementation on biochemical markers of bone formation in chil-dren and adolescents with cystic fibrosis. Eur J Pediatr 2006; 165: 540-5. [CrossRef]
24. van Summeren M, Braam L, Noirt F, Kuis W, Vermeer C. Pro-nounced elevation of undercarboxylated osteocalcin in healthy chil-dren. Pediatr Res 2007; 61: 366-70. [CrossRef]
23. Weber P. Vitamin K and bone health. Nutrition 2001; 17: 880-7. [CrossRef]
22. Lanham-New SA. Importance of calcium, vitamin D and vitamin K for osteoporosis preventation and treatment. Proc Nutr Soc 2008; 67: 163-76. [CrossRef]
21. Booth SL, Tucker KL, Chen H, et al. Dietary vitamin K in-takes are associated with hip fracture but not with bone min-eral density in elderly men and women. Am J Clin Nutr 2000; 71: 1201-8. [CrossRef]
20. Bolton-Smith C, McMurdo ME, Paterson CR, et al. Two-year ran-domized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 2007; 22: 509-19. [CrossRef]
19. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementa-tion improves hip bone geometry and bone strength indices in post-menopausal women. Osteoporos Int 2007; 18: 963-72. [CrossRef]
18. McLean RR, Booth SL, Kiel DP, et al. Association of dietary and biochemical measures of vitamin K with quantitative ultrasound of the heel menand women. Osteoporos Int 2006; 17: 600-7. [CrossRef]
17. Bardella MT, Bianchi ML, Teti A. Chronic inflammatory intestinal diseases and bone loss. Gut 2005, 54: 1508.
16. Turner J, Pellrin G, Mager D. Prevalence of metabolic bone disease in children with celiac disease is independent of symptoms at di-agnosis. J Pediatr Gastroenterol Nutr 2009; 49: 589-93. [CrossRef]
15. Tau C, Mautalen C, De Rosa S, Roca A, Valenzuela X. Bone mineral density in children with celiac disease. Effect of a gluten-free diet. Eur J Clin Nutr 2006; 60: 358-63. [CrossRef]
14. Blazina S, Bratanic N, Campa AS, Blagus R, Orel R. Bone mineral density and importance of strict gluten-free diet in children and ad-olescents with celiac disease. Bone 2010; 47: 598-603. [CrossRef]
13. Sdepanian VL, Carvalho CN, Morais MB, Fagundes Neto U. Bone mineral density of the lumbar spine in children and adolescents with celiac disease on gluten-free diet in Sao Paulo, Brasil. J Pediatr Gas-troenterol Nutr 2003; 37: 571-6. [CrossRef]
12. Kavak US, Yüce A, Koçak N, et al. Bone mineral density in children with untreated and treated celiac disease. J Pediatr Gastroenterol Nutr 2003; 37: 434-6. [CrossRef]
11. Kalayci AG, Kansu A, Girgin N, Kucuk O, Aras G. Bone mineral density and importance of a gluten free diet in patients with celiac disease in childhood. Pediatrics 2001; 108: E89. [CrossRef]
10. Lewiecki EM, Gordon CM, Baim S, et al. International Society for Clinical Densitometry 2007 adult and pediatric official positions. Bone 2008; 43: 1115-21. [CrossRef]
9. Goksen D, Darcan S, Coker M, Kose T. Bone mineral density of healthy Turkish children and adolescents. J Clin Densitom 2006; 9: 84-90. [CrossRef]
8. Gordon CM, Bachrach LK, Carpenter TO, et al. Dual energy X-ray absorptiometry interpretation and reporting in children and ado-lescent: the 2007 ISCD Pediatric Official Positions. J Clin Densitom 2008; 11: 43-58. [CrossRef]
7. Neyzi O, Gunoz H, Furman A, et al. Weight, height, head circum-ference and body mass index references for Turkish children. Turk J Pediatr 2008; 51:1-14 .
6. Husby S, Koletzko S, Korponay-Szabó IR; ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Commit-tee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. European Society for Pediatric Gastroenterology, Hepatolo-gy, and Nutrition guidelines for the diagnosis of coeliac disease. J Pe-diatr Gastroenterol Nutr 2012; 54: 136-60. [CrossRef]
5. Weber P. Vitamin K and bone health. Nutrition 2001; 17: 880-7. [CrossRef]
4. Mora S. Celiac disease in children: impact on bone health. Rev En-docr Metab Disord 2008; 9: 123-30. [CrossRef]
3. Newton KP, Singer SA. Celiac disease in children and adolescents: special considerations. Semin İmmunopathol 2012; 34: 479-96. [CrossRef]
2. Dalgic B, Sari S, Basturk B; Turkish Celiac Study Group. Prevalence of celiac disease in healthy Turkish school children. Am J Gastroen-terol 2011; 106: 1512-7. [CrossRef]
1. Tack GJ, Verbeek WH, Schreurs MW, Mulder CJ. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol 2010; 7: 204-13. [CrossRef]

APA	Volkan B, Fettah A, Islek A, KARA S, KURT N, Cayir A (2018). Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. , 215 - 220.
Chicago	Volkan Burcu,Fettah Ali,Islek Ali,KARA Soner SERTAN,KURT Nezahat,Cayir Atilla Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. (2018): 215 - 220.
MLA	Volkan Burcu,Fettah Ali,Islek Ali,KARA Soner SERTAN,KURT Nezahat,Cayir Atilla Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. , 2018, ss.215 - 220.
AMA	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. . 2018; 215 - 220.
Vancouver	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. . 2018; 215 - 220.
IEEE	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A "Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?." , ss.215 - 220, 2018.
ISNAD	Volkan, Burcu vd. "Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?". (2018), 215-220.

APA	Volkan B, Fettah A, Islek A, KARA S, KURT N, Cayir A (2018). Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. Turkish Journal of Gastroenterology, 29(2), 215 - 220.
Chicago	Volkan Burcu,Fettah Ali,Islek Ali,KARA Soner SERTAN,KURT Nezahat,Cayir Atilla Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. Turkish Journal of Gastroenterology 29, no.2 (2018): 215 - 220.
MLA	Volkan Burcu,Fettah Ali,Islek Ali,KARA Soner SERTAN,KURT Nezahat,Cayir Atilla Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. Turkish Journal of Gastroenterology, vol.29, no.2, 2018, ss.215 - 220.
AMA	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. Turkish Journal of Gastroenterology. 2018; 29(2): 215 - 220.
Vancouver	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?. Turkish Journal of Gastroenterology. 2018; 29(2): 215 - 220.
IEEE	Volkan B,Fettah A,Islek A,KARA S,KURT N,Cayir A "Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?." Turkish Journal of Gastroenterology, 29, ss.215 - 220, 2018.
ISNAD	Volkan, Burcu vd. "Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?". Turkish Journal of Gastroenterology 29/2 (2018), 215-220.