Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume
Yıl: 2018 Cilt: 24 Sayı: 1 Sayfa Aralığı: 11 - 14 Metin Dili: İngilizce DOI: 10.4274/tod.07108 İndeks Tarihi: 20-12-2018
Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume
Öz: Objective: Vitamin D is important for calcium and phosphorus metabolism as well as bone homeostasis. Moreover, its receptors weredetected in immune system, brain, eyes, pancreas, heart, adipose tissue, thyroid and parathyroid tissues in addition to other tissues andvitamin D deficiency is thought to play a role in immune system response, autoimmune diseases, infectious diseases, some types of cancers,and cardiovascular and metabolic diseases as well. In this study, our main objective is to assess the relationship between 25-hydroxy-D3[25(OH)D3] deficiency and inflammation; using C-reactive protein (CRP), platelet to lymphocyte rate (PLR), neutrophil to lymphocyte ratio(NLR) and mean platelet volume (MPV) parameters.Materials and Methods: This retrospective-cross-sectional study included 122 patients with diagnosed 25(OH)D3 deficiency and 85 controls.Patients’ CRP, NLR, PLR and MPV values were recorded and investigated.Results: There was no significant difference between the patients with 25(OH)D3 deficiency and control group in terms of NLR, PLR and MPV(p>0.05). However, CRP was significantly higher in 25(OH)D3 deficiency patients (p=0.001). No correlation between the values were detected.Conclusion: In our study, CRP values were significantly higher in patients with 25(OH)D3 deficiencies. However, we were unable to find asignificant relationship between 25(OH)D3 deficiency and NLR, PLR and MPV values. In order to assess the relationship between inflammationand vitamin D deficiency properly, well-designed prospective randomized controlled studies with wider series are required.
Anahtar Kelime: Konular:
D Vitamini ve Enflamasyon İlişkisinin Nötrofil Lenfosit Oranı, Trombosit Lenfosit Oranı ve Ortalama Trombosit Hacmi ile Değerlendirilmesi
Öz: Amaç: D vitamini kalsiyum ve fosfor metabolizmasında ve kemik homeostazında önemli rol oynamaktadır. Bunun yanı sıra immün sistem, beyin, gözler, pankreas, kalp, yağ dokusu, tiroit, paratitoid gibi birçok doku ve organda reseptörü gösterilmiş ve D vitamini eksikliğinin immün yanıtın düzenlenmesinde, otoimmün hastalıklarda, enfeksiyöz hastalıklarda, çeşitli kanserlerde, kardiyovasküler ve metabolik hastalıklarda da önemli rol oynadığı ileri sürülmüştür. Bu çalışmada 25-hidroksi-D3 [25(OH)D3] eksikliğinin enflamasyonla ilişkisinin nötrofil lenfosit oranı (NLO), trombosit lenfosit oranı (TLO) ve ortalama trombosit hacmi (OTH) parametreleri kullanılarak değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Bu retrospektif-kesitsel çalışmaya 25(OH)D3 eksikliği olan 122 hasta ile 85 kontrol alınmıştır. Hastaların C-reaktif protein (CRP), NLO, TLO ve OTH değerleri kaydedilmiş ve incelenmiştir. Bulgular: 25(OH)D3 eksikliği olan hastalar ile kontrol grubu arasında NLO, TLO ve OTH açısından anlamlı fark saptanmamıştır (p>0,05). 25(OH) D3 eksikliği olan hastalarda CRP anlamlı olarak yüksek bulunmuştur (p=0,001). Değerler arasında herhangi bir korelasyon saptanmamıştır. Sonuç: Çalışmamızda D vitamini eksikliği ile NLO, TLO ve OTH değerleri arasında anlamlı bir ilişki saptanmazken; CRP, D vitamini eksikliği olan hastalarda yüksek olarak bulunmuştur. D vitamini eksikliği ile yüksek MPV arasındaki ilişkiyi düzgün bir şekilde değerlendirmek için, iyi dizayn edilmiş prospektif, randomize kontrollü çalışmaların daha geniş serilerle yapılması gereklidir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | UMAY ALTAŞ E, TOSUN A (2018). Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. , 11 - 14. 10.4274/tod.07108 |
| Chicago | UMAY ALTAŞ Elif,TOSUN Aliye Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. (2018): 11 - 14. 10.4274/tod.07108 |
| MLA | UMAY ALTAŞ Elif,TOSUN Aliye Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. , 2018, ss.11 - 14. 10.4274/tod.07108 |
| AMA | UMAY ALTAŞ E,TOSUN A Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. . 2018; 11 - 14. 10.4274/tod.07108 |
| Vancouver | UMAY ALTAŞ E,TOSUN A Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. . 2018; 11 - 14. 10.4274/tod.07108 |
| IEEE | UMAY ALTAŞ E,TOSUN A "Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume." , ss.11 - 14, 2018. 10.4274/tod.07108 |
| ISNAD | UMAY ALTAŞ, Elif - TOSUN, Aliye. "Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume". (2018), 11-14. https://doi.org/10.4274/tod.07108 |
| APA | UMAY ALTAŞ E, TOSUN A (2018). Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. Türk Osteoporoz Dergisi, 24(1), 11 - 14. 10.4274/tod.07108 |
| Chicago | UMAY ALTAŞ Elif,TOSUN Aliye Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. Türk Osteoporoz Dergisi 24, no.1 (2018): 11 - 14. 10.4274/tod.07108 |
| MLA | UMAY ALTAŞ Elif,TOSUN Aliye Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. Türk Osteoporoz Dergisi, vol.24, no.1, 2018, ss.11 - 14. 10.4274/tod.07108 |
| AMA | UMAY ALTAŞ E,TOSUN A Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. Türk Osteoporoz Dergisi. 2018; 24(1): 11 - 14. 10.4274/tod.07108 |
| Vancouver | UMAY ALTAŞ E,TOSUN A Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume. Türk Osteoporoz Dergisi. 2018; 24(1): 11 - 14. 10.4274/tod.07108 |
| IEEE | UMAY ALTAŞ E,TOSUN A "Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume." Türk Osteoporoz Dergisi, 24, ss.11 - 14, 2018. 10.4274/tod.07108 |
| ISNAD | UMAY ALTAŞ, Elif - TOSUN, Aliye. "Assessment of Vitamin D and Inflammatory Response Relationship Using Neutrophil to Lymphocyte Ratio, Platelet to Lymphocyte Ratio and Mean Platelet Volume". Türk Osteoporoz Dergisi 24/1 (2018), 11-14. https://doi.org/10.4274/tod.07108 |
