TY  - JOUR
TI  - Clinical and Laboratory Results and Prognosis Patients with Scleroderma: A Single Center Experience
AB  - Systemic scleroderma (SSc) is a rare connective tissue disease accompanied by progressive fibrosis. Especiallypulmonary, cardiac and renal involvement is a major cause of morbidity and mortality in the disease while skin involvement andRaynaud's phenomenon (RP) can also decrease the quality of life by increasing morbidity. In this study, our aim was to determinethe demographics, organ involvement and prognosis of our SSc patients followed up in Rheumatology department and compare thedata with the literature. For this purpose, the data of 79 patients who were followed up in our department were evaluatedretrospectively. 74 (93.7%) of the 79 patients were female, the mean age of the patients was 54.3 ± 12.7 (22-76) years and the meanduration of disease was 7.29 ± 7.02 years. 71 (89.8%) had limited cutaneous SSc (lcSSc), 6 (7.6%) had diffuse cutaneous SSc(dcSSc) and 2 (2.5%) had sine scleroderma. When the cumulative organ involvement of the patients was evaluated, it was seen that73 (92.4%) had RP, 63 (79.7%) sclerodactyly, 14 (17.7%) digital ulcer and 22 (27.8%) telangiectasia. Eight (10.1%) patients hadarticular complaints. Antinuclear antibody (ANA) was (+) in 49 (62%) of the patients and anti-Scl-70 was (+) in 31 (39.2%). 74patients (93.7%) were still alive and 5 (6.3%) died. No disease-related factor was found to be effective on mortality (p> 0.05).Malignancy was developed in 4 (5.1%) patients. Only high resolution computed chest tomography (HRCT) shot count were foundto be an effective factor for cancer development (OR 1.74, p = 0.023 (CI 1.081-2.829). In conclusion, causes of mortality andmalignancy were similar with the literature in patients we followed up with SSc. We found a correlation between the incidence ofchest CT and the malignancy development unlike the literature. This result should be supported by studies involving larger patientnumbers.
AU  - OZDEN YİLMAZ, Ebru
AU  - KORKMAZ, Cengiz
AU  - ÜSKÜDAR CANSU, Döndü
DO  - 10.20515/otd.415387
PY  - 2018
JO  - Osmangazi Tıp Dergisi
VL  - 40
IS  - 3
SN  - 1305-4953
SP  - 70
EP  - 78
DB  - TRDizin
UR  - http://search/yayin/detay/289152
ER  -