TY - JOUR TI - Dexketoprofen effectively reduces postoperative pain and meperidine consumption after lumbar discectomy and laminectomy AB - Postopeartive pain is a major contributor to increased morbidity. Analgesia is important in reducing postoperativemorbidity and hospital stay. We aimed to determine the efficacy and side effect profile of preemptive and postoperative multimodaluse of dexketoprofen added to meperidine patient-controlled analgesia infusion in patients undergoing lumbar discectomy andlaminectomy. In this randomised, prospective, single-blind placebo-controlled trial, 60 patients undergoing laminectomy anddiscectomy were randomly (1:1) divided into two: Group I received placebo whereas Group II received 50 milligrammesdexketoprofen intravenously 30 minutes before surgery and 8 hours after the first dose. VAS scores, overall patient satisfaction,analgesic related side effects (nausea, vomiting, dyspepsia, bleeding, headache, hypotension, bradycardia, respiratory distress,pruritus) at hours 1, 4, 8, 12 and 24 were collected after surgery. Bleeding was recorded as the total value of aspirations duringsurgery, a number of sponges used during surgery and postoperative bleeding from vacuum drainage tubes. Groups were distributedsimilarly regarding age, sex, weight, ASA, anaesthesia and surgery time. Intraoperative and postoperative bleeding was similar.First time for PCA analgesic requirement was shorter in Group I. Group II had lower VAS scores on postoperative hours 1, 4, 8, 12and 24. The total dosage of meperidine was lower in Group II at the 4th, 12th and 24th hours. Group II had lower rates ofgastrointestinal side effects and headache related with analgesic use and had higher rates of satisfaction in regards of postoperativeanalgesia. Current study shows the multimodal use of dexketoprofen is a safe and effective analgesia option in patients undergoinglumbar discectomy and laminectomy. Dexketoprofen is not associated with increased frequency side effects or bleeding. AU - YELKEN, Birgül AU - ceylan, ilkay AU - YILDIZ, İSMAİL DO - 10.20515/otd.415188 PY - 2018 JO - Osmangazi Tıp Dergisi VL - 40 IS - 3 SN - 1305-4953 SP - 79 EP - 85 DB - TRDizin UR - http://search/yayin/detay/289153 ER -