Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis
Yıl: 2018 Cilt: 35 Sayı: 3 Sayfa Aralığı: 250 - 255 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.2017.0323 İndeks Tarihi: 02-01-2019
Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis
Öz: Background: Carotid artery stenosis is the atherosclerotic narrowingof the proximal internal carotid artery and one of the primary causesof stroke. Elevated expression of the pleiotropic proinflammatorycytokine interleukin-18 has been demonstrated in humanatherosclerotic plaques.Aims: To investigate whether the mRNA expression levels ofinterleukin-18 and interleukin-18-binding protein and interleukin-18−137 G/C (rs187238) variants are associated with carotid arterystenosis development.Study Design: Case-control study.Methods: The mRNA expression levels of interleukin-18 andinterleukin-18-binding protein and interleukin-18 rs187238 variantswere evaluated by quantitative real-time polymerase chain reactionand real-time polymerase chain reaction, respectively, in the peripheralblood mononuclear cells of 70 patients with carotid artery stenosis (36symptomatic, 34 asymptomatic) and 75 healthy controls.Results: Interleukin-18 mRNA expression was significantly increasedin carotid artery stenosis patients compared to that in healthy controls(p=0.01). However, no significant difference was observed betweeninterleukin-18-binding protein mRNA expression levels in patientswith carotid artery stenosis and those in controls (p=0.101). Internalcarotid artery stenosis severity was significantly higher in symptomaticpatients than that in asymptomatic patients (p<0.001). A significantrelationship was identified between interleukin-18 expression andinternal carotid artery stenosis severity in patients with carotid arterystenosis (p=0.051). Interleukin-18 rs187238 polymorphism genotypefrequencies did not significantly differ between patients with carotidartery stenosis and controls (p=0.246). A significant difference wasidentified between interleukin-18-binding protein gene expressionand symptomatic and asymptomatic patients (p=0.026), but there wasno difference in interleukin-18 expression between the symptomaticand asymptomatic subgroups (p=0.397).Conclusion: Interleukin-18 mRNA expression may affect carotidartery stenosis etiopathogenesis and internal carotid artery stenosisseverity and also may play a mechanistic role in the pathogenesis ofcarotid artery stenosis, influencing the appearance of symptoms.
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| APA | Arapi B, Bayoglu B, CENGİZ M, GOKSEL G, DEŞER S, Junisbekov Y, Arslan C (2018). Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. , 250 - 255. 10.4274/balkanmedj.2017.0323 |
| Chicago | Arapi Berk,Bayoglu Burcu,CENGİZ Müjgan,GOKSEL Gamze,DEŞER SERKAN BURÇ,Junisbekov Yerik,Arslan Caner Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. (2018): 250 - 255. 10.4274/balkanmedj.2017.0323 |
| MLA | Arapi Berk,Bayoglu Burcu,CENGİZ Müjgan,GOKSEL Gamze,DEŞER SERKAN BURÇ,Junisbekov Yerik,Arslan Caner Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. , 2018, ss.250 - 255. 10.4274/balkanmedj.2017.0323 |
| AMA | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. . 2018; 250 - 255. 10.4274/balkanmedj.2017.0323 |
| Vancouver | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. . 2018; 250 - 255. 10.4274/balkanmedj.2017.0323 |
| IEEE | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C "Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis." , ss.250 - 255, 2018. 10.4274/balkanmedj.2017.0323 |
| ISNAD | Arapi, Berk vd. "Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis". (2018), 250-255. https://doi.org/10.4274/balkanmedj.2017.0323 |
| APA | Arapi B, Bayoglu B, CENGİZ M, GOKSEL G, DEŞER S, Junisbekov Y, Arslan C (2018). Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. Balkan Medical Journal, 35(3), 250 - 255. 10.4274/balkanmedj.2017.0323 |
| Chicago | Arapi Berk,Bayoglu Burcu,CENGİZ Müjgan,GOKSEL Gamze,DEŞER SERKAN BURÇ,Junisbekov Yerik,Arslan Caner Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. Balkan Medical Journal 35, no.3 (2018): 250 - 255. 10.4274/balkanmedj.2017.0323 |
| MLA | Arapi Berk,Bayoglu Burcu,CENGİZ Müjgan,GOKSEL Gamze,DEŞER SERKAN BURÇ,Junisbekov Yerik,Arslan Caner Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. Balkan Medical Journal, vol.35, no.3, 2018, ss.250 - 255. 10.4274/balkanmedj.2017.0323 |
| AMA | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. Balkan Medical Journal. 2018; 35(3): 250 - 255. 10.4274/balkanmedj.2017.0323 |
| Vancouver | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis. Balkan Medical Journal. 2018; 35(3): 250 - 255. 10.4274/balkanmedj.2017.0323 |
| IEEE | Arapi B,Bayoglu B,CENGİZ M,GOKSEL G,DEŞER S,Junisbekov Y,Arslan C "Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis." Balkan Medical Journal, 35, ss.250 - 255, 2018. 10.4274/balkanmedj.2017.0323 |
| ISNAD | Arapi, Berk vd. "Increased Expression of Interleukin-18 mRNA is Associated with Carotid Artery Stenosis". Balkan Medical Journal 35/3 (2018), 250-255. https://doi.org/10.4274/balkanmedj.2017.0323 |
