Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature

Hasan YILMAZ, (Department of Urology, Kocaeli University School of Medicine, Kocaeli, Turkey)
Ufuk YAVUZ, (Clinic of Urology, Karaman State Hospital, Karaman, Turkey)
Murat ÜSTÜNER, (Clinic of Urology, Derince Training and Research Hospital, Kocaeli, Turkey)
Seyfettin ÇİFTÇİ, (Clinic of Urology, Sivas Numune Hospital, Sivas, Turkey)
Hikmet YAŞAR, (Clinic of Urology, Darıca Farabi State Hospital, Kocaeli, Turkey)
Bahar MÜEZZİNOĞLU, (Department of Pathology, Kocaeli University School of Medicine, Kocaeli, Turkey)
Ali Kemal USLUBAŞ, (Department of Urology, Kocaeli University School of Medicine, Kocaeli, Turkey)
Özdal DİLLİOĞLUGİL (Department of Urology, Kocaeli University School of Medicine, Kocaeli, Turkey)
Turkish Journal of Urology
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Yıl: 2017 Cilt: 43 Sayı: 3 Sayfa Aralığı: 297 - 302 Metin Dili: İngilizce DOI: 10.5152/tud.2017.03743 İndeks Tarihi: 10-01-2019

Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature

Öz:
Objective: Only a few papers in the literature aimed to evaluate biopsy core lengths. Additionally, studiesevaluated the core length with different approaches. We aimed to determine whether prostate cancer (PCa)detection is affected from core lengths according to three different approaches in a large standard cohort andcompare our cut-off values with the published cut-offs.Material and methods: We retrospectively analyzed 1,523 initial consecutive transrectal ultrasound-guided12-core prostate biopsies. Biopsies were evaluated with respect to total core length (total length of each patients'core) average core length (total core length divided by total number of cores in each patient), and meancore length (mean length of all cores pooled), and compared our cut-off values with the published cut-offs. Theprostate volumes were categorized into four groups (<30, 30-59.99, 60-119.99, ≥120 cm3) and PCa detectionrates in these categories were examined.Results: PCa was found in 41.5% patients. There was no difference between benign and malignant mean corelengths of the pooled cores (p>0.05). Total core length and average core length were not significantly associatedwith PCa in multivariate logistic regression analyses (p>0.05). The core lengths (mean, average and totalcore lengths) increased (p<0.001) and PCa rates decreased (p<0.001) steadily with increasing prostate volumecategories. PCa percentages decreased in all categories above the utilized cut-offs for mean (p>0.05), average(p<0.05), and total core lengths (p>0.05).Conclusion: There was no difference between mean core lengths of benign and malignant cores. Total corelength and average core length were not significantly associated with PCa. Contrary to the cut-offs used formean and average core lengths in the published studies, PCa rates decrease as these core lengths increase.Larger studies are necessary for the determination and acceptance of accurate cut-offs
Anahtar Kelime:

Konular: Üroloji ve Nefroloji

Daha uzun örnekler biyopside daha fazla prostat kanseri saptanmasına yol açmıyor: Literatürdeki kesme değerlerine karşı geniş bir kohort çalışması

Öz:
Amaç: Literatürde biyopsi örnek uzunluklarını değerlendirilmeyi amaçlayan sadece birkaç çalışma bulunmaktadır ve mevcut çalışmalardan her biri örnek uzunluklarını farklı yaklaşımlarla değerlendirmiştir. Standart ve çok hasta sayılı geniş kohort çalışmamızda, üç farklı yaklaşıma göre prostat kanseri (PKa) saptanmasına örnek uzunluklarının etkisini değerlendirmeyi ve bunun yayınlanmış kesme değerler ile kıyaslanmasını amaçladık. Gereç ve yöntemler: İlk kez 12 kor transrektal ultrasonografi kılavuzluğunda prostat biyopsisi yapılmış ardışık 1523 hastanın örnekleri geriye dönük analiz edildi. Biyopsiler toplam örnek uzunluğuna (her bir hastanın tüm örneklerinin toplamı), averaj örnek uzunluğuna (her bir hastanın toplam örnek uzunluğunun toplam örnek sayısına bölünmesiyle), ve ortalama örnek uzunluğuna (toplanmış tüm örneklerin ortalaması ) göre değerlendirildi ve yayınlanmış kesme değerlerle karşılaştırıldı. Prostat hacimleri dört gruba (<30, 30-59,99, 60-119,99, ≥120 cm3) ayrıldı ve bu kategorilerde saptanan PKa oranları incelendi. Bulgular: Hastaların %41,5’inde PKa saptandı. Havuzlanmış örneklerde benign ve malign örneklerin ortalama uzunlukları arasında fark yoktu (p>0,05). Çok değişkenli lojistik regresyon analizlerinde toplam örnek uzunluğu ve averaj örnek uzunluğu ile PKa saptanmasında anlamlı ilişkili saptanmadı (p>0,05). Artan prostat hacimlerinde örnek uzunlukları (ortalama, averaj ve toplam) artarken (p<0,001), PKa'nın oranı giderek (p<0,001) azaldı. Ortalama örnek uzunluğu (p>0,05), averaj örnek uzunluğu (p<0,05) için yayınlanmış ve toplam örnek uzunluğu (p>0,05) için belirlenmiş kesme değerlerinin üstündeki değerlerde PKa saptanma oranlarının azaldığı saptandı. Sonuç: Benign ve malign örneklerin ortalama uzunlukları arasında fark saptanmadı. Toplam örnek uzunluğu ve averaj örnek uzunluğu ile PKa arasında anlamlı ilişki saptanmadı. Ortalama ve averaj örnek uzunluğu için kesme değeri öneren çalışmaların aksine PKa saptanma oranı kesme değerler arttıkça azaldı. Daha uygun kesme değerlerin belirlenmesi ve kabul görmesi için daha büyük çalışmalar gerekmektedir.
Anahtar Kelime:

Konular: Üroloji ve Nefroloji
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yılmaz H, YAVUZ U, Ustuner M, ÇİFTÇİ S, YAŞAR H, MÜEZZİNOĞLU B, Uslubas A, DİLLİOĞLUGİL Ö (2017). Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. , 297 - 302. 10.5152/tud.2017.03743
Chicago Yılmaz Hasan,YAVUZ Ufuk,Ustuner Murat,ÇİFTÇİ Seyfettin,YAŞAR Hikmet,MÜEZZİNOĞLU Bahar,Uslubas Ali Kemal,DİLLİOĞLUGİL Özdal Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. (2017): 297 - 302. 10.5152/tud.2017.03743
MLA Yılmaz Hasan,YAVUZ Ufuk,Ustuner Murat,ÇİFTÇİ Seyfettin,YAŞAR Hikmet,MÜEZZİNOĞLU Bahar,Uslubas Ali Kemal,DİLLİOĞLUGİL Özdal Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. , 2017, ss.297 - 302. 10.5152/tud.2017.03743
AMA Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. . 2017; 297 - 302. 10.5152/tud.2017.03743
Vancouver Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. . 2017; 297 - 302. 10.5152/tud.2017.03743
IEEE Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö "Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature." , ss.297 - 302, 2017. 10.5152/tud.2017.03743
ISNAD Yılmaz, Hasan vd. "Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature". (2017), 297-302. https://doi.org/10.5152/tud.2017.03743
APA Yılmaz H, YAVUZ U, Ustuner M, ÇİFTÇİ S, YAŞAR H, MÜEZZİNOĞLU B, Uslubas A, DİLLİOĞLUGİL Ö (2017). Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. Turkish Journal of Urology, 43(3), 297 - 302. 10.5152/tud.2017.03743
Chicago Yılmaz Hasan,YAVUZ Ufuk,Ustuner Murat,ÇİFTÇİ Seyfettin,YAŞAR Hikmet,MÜEZZİNOĞLU Bahar,Uslubas Ali Kemal,DİLLİOĞLUGİL Özdal Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. Turkish Journal of Urology 43, no.3 (2017): 297 - 302. 10.5152/tud.2017.03743
MLA Yılmaz Hasan,YAVUZ Ufuk,Ustuner Murat,ÇİFTÇİ Seyfettin,YAŞAR Hikmet,MÜEZZİNOĞLU Bahar,Uslubas Ali Kemal,DİLLİOĞLUGİL Özdal Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. Turkish Journal of Urology, vol.43, no.3, 2017, ss.297 - 302. 10.5152/tud.2017.03743
AMA Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. Turkish Journal of Urology. 2017; 43(3): 297 - 302. 10.5152/tud.2017.03743
Vancouver Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature. Turkish Journal of Urology. 2017; 43(3): 297 - 302. 10.5152/tud.2017.03743
IEEE Yılmaz H,YAVUZ U,Ustuner M,ÇİFTÇİ S,YAŞAR H,MÜEZZİNOĞLU B,Uslubas A,DİLLİOĞLUGİL Ö "Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature." Turkish Journal of Urology, 43, ss.297 - 302, 2017. 10.5152/tud.2017.03743
ISNAD Yılmaz, Hasan vd. "Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature". Turkish Journal of Urology 43/3 (2017), 297-302. https://doi.org/10.5152/tud.2017.03743
Sayfa Oluşturulma Tarihi
23-04-2024 7:10

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