TY  - JOUR
TI  - Longer biopsy cores do not increase prostate cancer detection rate: A large-scale cohort study refuting cut-off values indicated in the literature
AB  - Objective: Only a few papers in the literature aimed to evaluate biopsy core lengths. Additionally, studiesevaluated the core length with different approaches. We aimed to determine whether prostate cancer (PCa)detection is affected from core lengths according to three different approaches in a large standard cohort andcompare our cut-off values with the published cut-offs.Material and methods: We retrospectively analyzed 1,523 initial consecutive transrectal ultrasound-guided12-core prostate biopsies. Biopsies were evaluated with respect to total core length (total length of each patients'core) average core length (total core length divided by total number of cores in each patient), and meancore length (mean length of all cores pooled), and compared our cut-off values with the published cut-offs. Theprostate volumes were categorized into four groups (<30, 30-59.99, 60-119.99, ≥120 cm3) and PCa detectionrates in these categories were examined.Results: PCa was found in 41.5% patients. There was no difference between benign and malignant mean corelengths of the pooled cores (p>0.05). Total core length and average core length were not significantly associatedwith PCa in multivariate logistic regression analyses (p>0.05). The core lengths (mean, average and totalcore lengths) increased (p<0.001) and PCa rates decreased (p<0.001) steadily with increasing prostate volumecategories. PCa percentages decreased in all categories above the utilized cut-offs for mean (p>0.05), average(p<0.05), and total core lengths (p>0.05).Conclusion: There was no difference between mean core lengths of benign and malignant cores. Total corelength and average core length were not significantly associated with PCa. Contrary to the cut-offs used formean and average core lengths in the published studies, PCa rates decrease as these core lengths increase.Larger studies are necessary for the determination and acceptance of accurate cut-offs
AU  - Yılmaz, Hasan
AU  - Ustuner, Murat
AU  - MÜEZZİNOĞLU, Bahar
AU  - Uslubas, Ali Kemal
AU  - DİLLİOĞLUGİL, Özdal
AU  - YAŞAR, Hikmet
AU  - YAVUZ, Ufuk
AU  - ÇİFTÇİ, Seyfettin
DO  - 10.5152/tud.2017.03743
PY  - 2017
JO  - Turkish Journal of Urology
VL  - 43
IS  - 3
SN  - 2149-3235
SP  - 297
EP  - 302
DB  - TRDizin
UR  - http://search/yayin/detay/290252
ER  -