TY  - JOUR
TI  - Assessment of Quality of Life of Patients with Chronic Hepatitis B and C Treated with Pegylated Interferon-alpha
AB  - Objectives: It was aimed to evaluate health-related quality of lifeof patients with non-cirrhotic chronic hepatitis B (CHB) and chronichepatitis C (CHC) during interferon therapy with the standard shortform-36 (SF-36).Materials and Methods: This study included all patients whoattended the Atatürk University Faculty of Medicine, Department ofInfectious Diseases and Clinical Microbiology and outpatient clinicsfor treatment between June 2008 and June 2010 and met theinclusion criteria. A socio-demographic data questionnaire and SF36were administered in all subjects before the interferon therapyand in the third and sixth months of the treatment.Results: Before the treatment, vitality/energy (p=0.01) and generalhealth (p=0.01) scores in patients with CHB were lower than incontrols. In the sixth month of the therapy, physical function (p=0.03),role physical (p=0.011), role emotional (p=0.003) and vitality/energy(p=0.005) scores were significantly lower than in controls. There wasa significant difference in physical function (p=0.006), role physical(p=0.006), role emotional (p=0.001) and vitality/energy (p=0.000005)scores before the treatment and physical function (p=0.006),role physical (p=0.013), role emotional (p=0.001), vitality/energy(p=0.000005) and mental health (p=0.041) scores in the third monthof the treatment and physical function (p=0.000008), social function(p=0.005), role physical (p=0.0000008), role emotional (p=0.000007),mental health (p=0.001) and vitality/energy (p=0.000005) scores in thesixth month of the treatment between patients with CHC and controls.Conclusion: Providing guidance and counseling to patients withCHB and CHC about their illness and side effects of the drugs willincrease health-related quality of life of patients and will adapt themto their treatment.
AU  - Çelik, Neslihan
AU  - PARLAK, Emine
AU  - Parlak, Mehmet
AU  - ALAY, HANDAN
AU  - OZDEN, KEMALETTIN
AU  - EROL, Serpil
DO  - 10.4274/vhd.2017.0016
PY  - 2018
JO  - Viral Hepatitis Journal
VL  - 24
IS  - 2
SN  - 2147-2939
SP  - 25
EP  - 42
DB  - TRDizin
UR  - http://search/yayin/detay/291815
ER  -