The aim of the this study was to observe possible changes in coagulation profiles in dogs with septic shock. A total of 30 dogs (control group n=10, test group n=20) were used as materials in this study. Although different diseases leading to septic shock were diagnosed in dogs in the test group, dogs were selected on the basis of septic shock criteria such as fever or hypothermia, hypotension, leukopenia or leukocytosis and thrombocytopenia. In addition to the results of rutine clinical and laboratory examination, prothrombin time (PT), activated partial thromboplastin time (aPTT), antithrombin III (AT III), fibrinogen and fibrin split products (FSP), as well as factors (F-VIII and F-IX) playing role in the coagulation mechanism ,were evaluated. In the test group, clinical findings included fever (p<0.001), increased heart and respiratory rate (p<0.01), prolonged capillary filling time (CFT) (p<0.05) and weak femoral pulsation (p<0.001); and hematologically, while WBC count, RBC, Hgb, PCV, MCV and MCHC were not significantly changed, thrombocyte count was markedly decreased (p<0.001). In the test group, prolonged PT (p<0.05) and aPTT (p<0.01), decreased fibrinogen and AT III values and increased FSP (p<0.05) were determinated in the coagulation profiles. It was concluded that coagulation profiles were significantly changed in dogs with septic shock