TY  - JOUR
TI  - Investigation of Chemical Composition, Antioxidant, Anticholinesterase and Anti-urease activities of Euphorbia helioscopia
AB  - In this study, chemical composition, antioxidant, anticholinesterase andanti-urease activities of the essential oil, hexane, acetone, methanol and waterextracts of Euphorbia helioscopia were investigated. The chemical composition ofthe essential oil was analyzed by GC and GC/MS and β-cubebene (19.3 %),palmitic acid (12.2 %) and caryophyllene oxide (11.7 %) were identified as majorcompounds. The antioxidant activity of essential oil and extracts was performed byseveral methods such as β-carotene-linoleic acid, DPPH• , ABTS•+ radical scavenging, CUPRAC and metal chelating assays. The water extractshowed higher antioxidant activity than BHA and α-tocopherol in β-carotene-linoleic acid, DPPH•,ABTS•+ and CUPRAC assays with IC50: 1.08±0.39, 15.57±0.48, 1.89±0.33 and12.50±0.11 μg/mL values, respectively. Also, the anticholinesterase and antiureaseactivities were tested against acetylcholinesterase (AChE),butyrylcholinesterase (BChE) and urease enzymes, spectrophotometrically. Theacetone extract (81.23±0.58 %) showed very close BChE inhibitory activity togalantamine. The hexane extract (96.97±0.36 %) of E. helioscopia showed higheranti-urease activity than thiourea (96.93±0.17 %) whereas the essential oil(91.37±0.26 %) indicated very close anti-urease activity to the standard.
AU  - DURU, Mehmet Emin
AU  - DEVECİ, EBRU
AU  - Tel-Çayan, Gulsen
DO  - 10.21448/ijsm.433681
PY  - 2018
JO  - International Journal of Secondary Metabolite
VL  - 5
IS  - 3
SN  - 2148-6905
SP  - 259
EP  - 269
DB  - TRDizin
UR  - http://search/yayin/detay/292537
ER  -