Although intramuscular injections has been thought as an easy skill in nursing practice, it may cause serious complications when it’s applied in unsafe and unusual procedure. Comfort techniques, positioning, amount of drug, site selection and the amount of muscle mass of the children should be assessed prior to each intramuscular injections and determined by the child’s age and development. As an injection site, vastus lateralis for newborns and small children (<3 years), the deltoid and ventrogluteal region should be preferred for children age three and older children. For intramuscular injections, it is important to use correct technique as well as to choose the correct injection site. Therewithal, injection depth, the length of the needle and the application rate should be determined correctly for intramuscular injections. Pain management should be known to eliminate or reduce pain according to the child's age term and developmental characteristics. For effective pain management, in older age groups taking child’s participation and decisionmaking process are effective while combined non pharmalogical methods should be used in small children. Therefore, it is important for pediatric nurses to know safe injection practices of evidencebased practice. Nursing practice requires pediatric nurses to review current literature that includes the best practice to improve patient outcomes. The aim of this article is to evaluate pediatric intramuscular injections through current literature and available evidence.