Diagnostic value of hematological parameters in patients with osteoarthritis
Yıl: 2017 Cilt: 42 Sayı: 1 Sayfa Aralığı: 120 - 125 Metin Dili: İngilizce DOI: 10.17826/cutf.279696 İndeks Tarihi: 10-04-2019
Diagnostic value of hematological parameters in patients with osteoarthritis
Öz: Purpose: The aim of the present study was to investigate the diagnostic value of routine hematological parameters on osteoarthritis and to explore their clinical significance. Material and Methods: The study included 118 patients with osteoarthritis and 145 healthy individuals. Medical records, Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), white blood cell count (WBC), neutrophil-lymphocyte ratio (NLR), platelet count (PLT), platelet distribution width (PDW), platecrit (PCT), red cell distribution width (RDW), RDW-platelet ratio (RPR), platelet-lymphocyte ratio (PLR) and mean platelet volume (MPV) levels were retrospectively recorded from patient files.Results: There were no significant differences in WBC, RDW, PLT, RPR levels between two groups. NLR and PLR values were significantly higher in the OA group than in the control group. RBC, MPV, PCT and PDW values were significantly lower in the osteoarthritis group than in the control group. MPV and RBC were negatively correlated with ESR and CRP in osteoarthritis patients.Conclusions: Hematological inflammatory markers might be useful parameters that could be used in patients with osteoarthritis.
Anahtar Kelime: Osteoartrit hastalarında hematolojik parametrelerin tanısal değeri
Öz: Amaç: Bu çalışmanın amacı, osteoartrit hastalığında hematolojik parametrelerin tanısal değerini araştırmak ve klinik önemlerini ortaya koymaktır. Gereç ve Yöntemler: Çalışmaya 118 osteoartrit hastası ile yaş ve cinsiyeti benzer 145 sağlıklı birey dahil edildi. Tıbbi geçmişi, eritrosit sedimentasyon hızı (ESR), C-reaktif protein (CRP), beyaz küre sayısı (WBC), nötrofil-lenfosit oranı (NLR), platelet sayısı (PLT), platelet dağılım genişliği (PDW), platecrit (PCT), kırmızı küre dağılım genişliği (RDW), RDW-platelet oranı (RPR), platelet-lenfosit oranı (PLR) ve ortalama platelet hacmi (MPV) değerleri retrospektif olarak hasta dosyalarından elde edildi. Bulgular: İki grup arasında WBC, RDW, PLT, RPR değerleri arasında fark bulunamamıştır. NLR ve PLR değerleri osteoartrit hastalarında istatistiksel olarak kontrol grubuna göre anlamlı şekilde daha yüksek bulundu. RBC, MPV ve PDW değerleri, osteoartrit hastalarında istatistiksel olarak anlamlı şekilde daha düşük bulundu. Hasta grubunda ESR ve CRP değerleri, MPV ve RBC ile negatif şekilde korelasyon gösterdi. Sonuçlar: Bu çalışma, hematolojik inflamatuar parametrelerin osteoartrit hastalığında tanısal belirteçler olarak kullanılabileceğini göstermiştir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Sellam J, Berenbaum F. The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis. Nat Rev Rheumatol. 2010;6:625–35.
- 2. Goldring MB, Otero M. Inflammation in osteoarthritis. Curr Opin Rheumatol. 2011;23:471-8.
- 3. Benito MJ, Veale, DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. Ann Rheum Dis. 2005;64:1263-7.
- 4. Furuzawa-Carballeda J, Macip-Rodriguez PM, Cabral AR. Osteoarthritis and rheumatoid arthritis pannus have similar qualitative metabolic characteristics and pro-inflammatory cytokine response. Clin Exp Rheumatol. 2008;26:554-60.
- 5. Farahat MN, Yanni G, Poston R, Panayi GS. Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 1993;52:870-5.
- 6. Furuzawa-Carballeda J, Alcocer-varela J. Interleukin-8, interleukin-10, intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression levels are higher in synovial tissue from patients with rheumatoid arthritis than in osteoarthritis. Scand J Immunol. 1999;50:215–22.
- 7. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA et al. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008;75:291-4.
- 8. Özer S, Yılmaz R, Sönmezgöz E, Karaaslan E, Taşkın S, Bütün İ et al. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Med Sci Monit. 2015;21:298-303.
- 9. Sert A, Aypar E, Odabas D. Mean platelet volume in acute rheumatic fever. Platelets. 2013;24:378-82.
- 10. Öztürk ZA, Dag MS, Kuyumcu ME, Cam H, Yesil Y, Yilmaz N et al. Could platelet indices be new biomarkers for inflammatory bowel diseases? Eur Rev Med Pharmacol Sci. 2013;17:334-41.
- 11. Okuturlar Y, Soylu A, Dogan H, Cakmak S, Kirac Utku I, Oztosun B et al. Mean platelet volume in patients with biliary and non-biliary acute pancreatitis. Int J Clin Exp Pathol. 2015;8:2051-6.
- 12. Ipek S, Cekic C, Alper E, Coban E, Eliacik E, Arabul M et al. Can red cell distribution width be a marker of disease activity in ulcerative colitis? Int J Clin Exp Med. 2015;8:13848-53.
- 13. Rodríguez-Carrio J, Alperi-López M, López P, Alonso-Castro S, Carro-Esteban SR, Ballina-García FJ et al. Red cell distribution width is associated with endothelial progenitor cell depletion and vascular-related mediators in rheumatoid arthritis. Atherosclerosis. 2015;240:131-6.
- 14. Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H et al. Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) were Useful Markers in Assessment of Inflammatory Response and Disease Activity in SLE patients. Mod Rheumatol. 2015;25:1-16.
- 15. Fu H, Qin B, Hu Z, Ma N, Yang M, Wei T et al. Neutrophil- and platelet-to-lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269-73.
- 16. Karagoz E, Ulcay A, Tanoglu A, Kara M, Turhan V, Erdem H et al. Clinical usefulness of mean platelet volume and red blood cell distribution width to platelet ratio for predicting the severity of hepatic fibrosis in chronic hepatitis B virus patients. Eur J Gastroenterol Hepatol. 2014;26:1320-4.
- 17. Smith MD, Triantafillou S, Parker A, Youssef PP, Coleman M. Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997;24:365-71.
- 18. Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets. 2014;25:81-5.
- 19. Sen N, Basar N, Maden O, Ozcan F, Ozlu MF, Gungor O et al. Increased mean platelet volume in patients with slow coronary flow. Platelets. 2009;20:23-8.
- 20. Azab B, Torbey E, Singh J, Akerman M, Khoueiry G, McGinn JT et al. Mean platelet volume/platelet count ratio as a predictor of long-term mortality after non-ST-elevation myocardial infarction. Platelets 2011;22:557–66.
- 21. Cho SY, Lee A, Lee HJ, Suh J-T, Park TS. Mean platelet volume in Korean patients with hepatic diseases. Platelets. 2012;23:648-9.
- 22. Biljak VR, Pancirov D, Cepelak I, Popovic-Grle S, Stjepanovic G, Grubisic TZ. Platelet count, mean platelet volume and smoking status in stable chronic obstructive pulmonary disease. Platelets. 2011;22:466–70.
- 23. Bath PM, Butterworth RJ. Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis. 1996;7:157-61.
- 24. Li SF, Henderson J, Dickman E, Darzynkiewicz R. Laboratory tests in adults with monoarticular arthritis: can they rule out a septic joint? Acad Emerg Med. 2004;11:276-80.
- 25. Pierce CN, Larson DF. Inflammatory cytokine inhibition of erythropoiesis in patients implanted with a mechanical circulatory assist device. Perfusion. 2005;20:83-90.
- 26. Pearle AD, Scanzello CR, George S, Mandl LA, DiCarlo EF, Peterson M et al. Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis. Osteoarthritis Cartilage. 2007;15:516-23.
- 27. Sipe JD. Acute-phase proteins in osteoarthritis. Semin Arthritis Rheum. 1995;25:75-86.
- 28. Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR et al. Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997;40:723-7.
| APA | HIRA S, TAMAM C (2017). Diagnostic value of hematological parameters in patients with osteoarthritis. , 120 - 125. 10.17826/cutf.279696 |
| Chicago | HIRA Serdar,TAMAM Cüneyt Diagnostic value of hematological parameters in patients with osteoarthritis. (2017): 120 - 125. 10.17826/cutf.279696 |
| MLA | HIRA Serdar,TAMAM Cüneyt Diagnostic value of hematological parameters in patients with osteoarthritis. , 2017, ss.120 - 125. 10.17826/cutf.279696 |
| AMA | HIRA S,TAMAM C Diagnostic value of hematological parameters in patients with osteoarthritis. . 2017; 120 - 125. 10.17826/cutf.279696 |
| Vancouver | HIRA S,TAMAM C Diagnostic value of hematological parameters in patients with osteoarthritis. . 2017; 120 - 125. 10.17826/cutf.279696 |
| IEEE | HIRA S,TAMAM C "Diagnostic value of hematological parameters in patients with osteoarthritis." , ss.120 - 125, 2017. 10.17826/cutf.279696 |
| ISNAD | HIRA, Serdar - TAMAM, Cüneyt. "Diagnostic value of hematological parameters in patients with osteoarthritis". (2017), 120-125. https://doi.org/10.17826/cutf.279696 |
| APA | HIRA S, TAMAM C (2017). Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal, 42(1), 120 - 125. 10.17826/cutf.279696 |
| Chicago | HIRA Serdar,TAMAM Cüneyt Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal 42, no.1 (2017): 120 - 125. 10.17826/cutf.279696 |
| MLA | HIRA Serdar,TAMAM Cüneyt Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal, vol.42, no.1, 2017, ss.120 - 125. 10.17826/cutf.279696 |
| AMA | HIRA S,TAMAM C Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal. 2017; 42(1): 120 - 125. 10.17826/cutf.279696 |
| Vancouver | HIRA S,TAMAM C Diagnostic value of hematological parameters in patients with osteoarthritis. Cukurova Medical Journal. 2017; 42(1): 120 - 125. 10.17826/cutf.279696 |
| IEEE | HIRA S,TAMAM C "Diagnostic value of hematological parameters in patients with osteoarthritis." Cukurova Medical Journal, 42, ss.120 - 125, 2017. 10.17826/cutf.279696 |
| ISNAD | HIRA, Serdar - TAMAM, Cüneyt. "Diagnostic value of hematological parameters in patients with osteoarthritis". Cukurova Medical Journal 42/1 (2017), 120-125. https://doi.org/10.17826/cutf.279696 |
