Yıl: 2018 Cilt: 29 Sayı: 3 Sayfa Aralığı: 196 - 201 Metin Dili: İngilizce DOI: 10.12996/gmj.2018.55

The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy

Öz:
Background: Oral mucositis is defined as oral mucosal inflammation in cancerpatients that is caused by chemotherapy and/or radiotherapy. Propolis is anatural product produced by bees and has antimicrobial, antioxidant, and antiinflammatoryeffects. Therefore, considering the anti-inflammatory propertiesof Propolis, the aim of this study is to evaluate the efficacy of Propolis tablet onoral mucositis caused by chemotherapy.Materials and Methods: In this randomized, double-blinded, placebo-controlledstudy, 50 patients were enrolled in the study, and samples were taken frompatients on Folfox chemotherapy regimen with colon cancer who were admittedto the Oncology Center of Imam Khomeini Hospital in Sari. The patients werethen divided into two groups of 25. The first group received 50 mg Propolistablets as 2 tablets per day for 21 days and the second group received placebo.All patients were examined by oral medicine specialist after initial examination,weekly and for 3 weeks, and the severity of mucositis was recorded according toWHO criteria. Data analysis was performed in SPSS ver. 22 software using T testand Mann-Whitney and Kruskal-Wallis tests.Results: The age range of the participants in the study was between 26-72 years.In the intervention group 13 women (52%) and 12 men (48%) and in the controlgroup 13 women (52%) and 12 men (48%) participated .In this study, there wasa significant difference in the mean of oral mucositis severity in the Propolisgroup compared to placebo group. In the intervention group, oral mucositisgrade was significantly lower in the 2nd and 3rd follow up sessions than in theplacebo group (p <0.05). No negative complications were reported by patients.Conclusion: This clinical trial study showed that Propolis tablet could play animportant role in preventing and improving the oral mucositis caused bychemotherapy.
Anahtar Kelime:

Propolis Tabletinin Kemoterapiye Bağlı Gelişen Oral Mukozit Üzerine Etkisi

Öz:
Amaç: Oral mukozit, kemoterapi ve/veya radyoterapinin neden olduğu kanser hastalarında oral mukozal inflamasyon olarak tanımlanır. Propolis, arılar tarafından üretilen ve antimikrobiyal, antioksidan ve anti-inflamatuar etkileri olan doğal bir üründür. Bu nedenle, Propolis'in antiinflamatuar özellikleri göz önüne alınarak, bu çalışmanın amacı, Propolis tabletinin kemoterapinin neden olduğu oral mukozit üzerindeki etkinliğini değerlendirmektir. Yöntem: Bu randomize, çift-kör, plasebo kontrollü çalışmada, 50 hasta çalışmaya alındı ve Sari'deki Imam Khomeini Hastanesi Onkoloji Merkezine başvuran kolon kanseri olup Folfox kemoterapi rejiminde olan hastalardan örnekler alındı. Hastalar daha sonra 25'er iki gruba ayrıldı. İlk grup 21 gün boyunca günde 2 tablet olarak 50 mg Propolis tableti aldı ve ikinci grup plasebo aldı. Tüm hastalar ilk muayeneden sonra, haftalık ve 3 hafta boyunca diş hekimi tarafından muayene edildi ve WHO kriterlerine göre mukozit şiddeti kaydedildi. Veri analizi, T testi, Mann-Whitney ve Kruskal-Wallis testleri kullanılarak SPSS ver.22 yazılım ile yapıldı. Bulgular: Çalışmaya katılanların yaş aralığı 26-72 yıl arasındaydı. Müdahale grubunda 13 kadın (% 52), 12 erkek (% 48) ve kontrol grubunda 13 kadın (% 52),12 erkek (% 48) bu çalışmaya katılmıştır. Propolis grubunda plasebo grubuna göre oral mukozit şiddeti açısından istatistiksel olarak anlam vardı. Girişim grubunda oral mukozit derecesi 2. ve 3. takip seanslarında plasebo grubuna göre anlamlı olarak düşüktü (p <0.05). Hastalar tarafından hiçbir olumsuz komplikasyon bildirilmedi. Sonuç: Bu klinik çalışma çalışması, Propolis tabletinin kemoterapinin neden olduğu oral mukozitin önlenmesinde faydalı ve önemli bir rol oynayabileceğini göstermiştir.
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APA SALEHİ M, SAEEDİ M, GHORBANİ A, GHODRATİ P, MOOSAZADEH M, ROSTAMKALAEİ S, HATKEHLOUEİ M, MOLANİA T (2018). The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy. Gazi Medical Journal, 29(3), 196 - 201. 10.12996/gmj.2018.55
Chicago SALEHİ Maede,SAEEDİ Majid,GHORBANİ Anahita,GHODRATİ Parisa,MOOSAZADEH Mahmoud,ROSTAMKALAEİ Sohrab,HATKEHLOUEİ Mahdi Babaei,MOLANİA Tahereh The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy. Gazi Medical Journal 29, no.3 (2018): 196 - 201. 10.12996/gmj.2018.55
MLA SALEHİ Maede,SAEEDİ Majid,GHORBANİ Anahita,GHODRATİ Parisa,MOOSAZADEH Mahmoud,ROSTAMKALAEİ Sohrab,HATKEHLOUEİ Mahdi Babaei,MOLANİA Tahereh The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy. Gazi Medical Journal, vol.29, no.3, 2018, ss.196 - 201. 10.12996/gmj.2018.55
AMA SALEHİ M,SAEEDİ M,GHORBANİ A,GHODRATİ P,MOOSAZADEH M,ROSTAMKALAEİ S,HATKEHLOUEİ M,MOLANİA T The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy. Gazi Medical Journal. 2018; 29(3): 196 - 201. 10.12996/gmj.2018.55
Vancouver SALEHİ M,SAEEDİ M,GHORBANİ A,GHODRATİ P,MOOSAZADEH M,ROSTAMKALAEİ S,HATKEHLOUEİ M,MOLANİA T The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy. Gazi Medical Journal. 2018; 29(3): 196 - 201. 10.12996/gmj.2018.55
IEEE SALEHİ M,SAEEDİ M,GHORBANİ A,GHODRATİ P,MOOSAZADEH M,ROSTAMKALAEİ S,HATKEHLOUEİ M,MOLANİA T "The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy." Gazi Medical Journal, 29, ss.196 - 201, 2018. 10.12996/gmj.2018.55
ISNAD SALEHİ, Maede vd. "The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy". Gazi Medical Journal 29/3 (2018), 196-201. https://doi.org/10.12996/gmj.2018.55