TY  - JOUR
TI  - The Effect of Propolis Tablet on Oral Mucositis Caused by Chemotherapy
AB  - Background: Oral mucositis is defined as oral mucosal inflammation in cancerpatients that is caused by chemotherapy and/or radiotherapy. Propolis is anatural product produced by bees and has antimicrobial, antioxidant, and antiinflammatoryeffects. Therefore, considering the anti-inflammatory propertiesof Propolis, the aim of this study is to evaluate the efficacy of Propolis tablet onoral mucositis caused by chemotherapy.Materials and Methods: In this randomized, double-blinded, placebo-controlledstudy, 50 patients were enrolled in the study, and samples were taken frompatients on Folfox chemotherapy regimen with colon cancer who were admittedto the Oncology Center of Imam Khomeini Hospital in Sari. The patients werethen divided into two groups of 25. The first group received 50 mg Propolistablets as 2 tablets per day for 21 days and the second group received placebo.All patients were examined by oral medicine specialist after initial examination,weekly and for 3 weeks, and the severity of mucositis was recorded according toWHO criteria. Data analysis was performed in SPSS ver. 22 software using T testand Mann-Whitney and Kruskal-Wallis tests.Results: The age range of the participants in the study was between 26-72 years.In the intervention group 13 women (52%) and 12 men (48%) and in the controlgroup 13 women (52%) and 12 men (48%) participated .In this study, there wasa significant difference in the mean of oral mucositis severity in the Propolisgroup compared to placebo group. In the intervention group, oral mucositisgrade was significantly lower in the 2nd and 3rd follow up sessions than in theplacebo group (p <0.05). No negative complications were reported by patients.Conclusion: This clinical trial study showed that Propolis tablet could play animportant role in preventing and improving the oral mucositis caused bychemotherapy.
AU  - GHORBANİ, Anahita
AU  - HATKEHLOUEİ, Mahdi Babaei
AU  - SAEEDİ, Majid
AU  - SALEHİ, Maede
AU  - MOOSAZADEH, Mahmoud
AU  - ROSTAMKALAEİ, Sohrab
AU  - MOLANİA, Tahereh
AU  - GHODRATİ, Parisa
DO  - 10.12996/gmj.2018.55
PY  - 2018
JO  - Gazi Medical Journal
VL  - 29
IS  - 3
SN  - 1300-056X
SP  - 196
EP  - 201
DB  - TRDizin
UR  - http://search/yayin/detay/294908
ER  -