Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid

Esra DEMİREL, (Erzurum Bölge Egitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Klinigi, Erzurum, Türkiye)
Kadri YILDIZ, (Erzurum Palandöken Devlet Hastanesi, Ortopedi ve Travmatoloji Kliniği, Erzurum, Türkiye)
Kenan ÇADIRCI, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, İç Hastalıkları Bölümü, Erzurum, Türkiye)
Hayati AYGÜN, (Özel Medicabil Hastanesi, Ortopedi ve Travmatoloji Kliniği, Bursa, Türkiye)
Eyüp ŞENOCAK, (Erzurum Palandöken Devlet Hastanesi, Ortopedi ve Travmatoloji Kliniği, Erzurum, Türkiye)
Betül GÜNDOĞDU (Atatürk Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)
Acta Orthopaedica et Traumatologica Turcica
5 0
Yıl: 2018 Cilt: 52 Sayı: 6 Sayfa Aralığı: 469 - 474 Metin Dili: İngilizce DOI: 10.1016/j.aott.2018.07.005 İndeks Tarihi: 17-04-2019

Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid

Öz:
Objective: In this experimental study, PRF (Platelet Rich Fibrin), HA (Hyaluronic Acid) gel and ADCON®Gel were compared in terms of preventing epidural fibrosis.Methods: Twenty-eight SpragueeDawley rats (mean weight, 400e450 g) were divided into 4 groups. L3-L4 laminectomy was performed in each group. Following laminectomy, Adcon® Gel, HA gel and PRF wereapplied onto the surgery site locally in Group 1, 2 and 3, respectively. Group 4 was maintained as controlwithout any local application. After five weeks, L3-L4 vertebrae were removed totally and taken tohistopathological evaluation for epidural fibrosis, acute inflammatory cell density, chronic inflammatorycell density, hemorrhage, angiogenesis and new bone formation.Results: Acute inflammation cell density, angiogenesis, and new bone formation levels were comparableamong the study groups (p > 0.05). However, new bone formation was higher in the PRF group. Epiduralfibrosis and chronic inflammatory cell density were significantly lower in the PRF group (p < 0.05).Conclusion: We concluded that PRF contributed to hemostasis and prevented epidural fibrosis.Crown Copyright © 2018 Turkish Association of Orthopaedics and Traumatology. Publishing services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Hayati Aygün d , Betül Gündogdu e
Anahtar Kelime:

Konular: Ortopedi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Bibliyografik
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APA Demirel E, YILDIZ K, ÇADIRCI K, AYGÜN H, Şenocak E, GÜNDOĞDU B (2018). Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. , 469 - 474. 10.1016/j.aott.2018.07.005
Chicago Demirel Esra,YILDIZ Kadri,ÇADIRCI Kenan,AYGÜN Hayati,Şenocak Eyüp,GÜNDOĞDU BETÜL Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. (2018): 469 - 474. 10.1016/j.aott.2018.07.005
MLA Demirel Esra,YILDIZ Kadri,ÇADIRCI Kenan,AYGÜN Hayati,Şenocak Eyüp,GÜNDOĞDU BETÜL Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. , 2018, ss.469 - 474. 10.1016/j.aott.2018.07.005
AMA Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. . 2018; 469 - 474. 10.1016/j.aott.2018.07.005
Vancouver Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. . 2018; 469 - 474. 10.1016/j.aott.2018.07.005
IEEE Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B "Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid." , ss.469 - 474, 2018. 10.1016/j.aott.2018.07.005
ISNAD Demirel, Esra vd. "Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid". (2018), 469-474. https://doi.org/10.1016/j.aott.2018.07.005
APA Demirel E, YILDIZ K, ÇADIRCI K, AYGÜN H, Şenocak E, GÜNDOĞDU B (2018). Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. Acta Orthopaedica et Traumatologica Turcica, 52(6), 469 - 474. 10.1016/j.aott.2018.07.005
Chicago Demirel Esra,YILDIZ Kadri,ÇADIRCI Kenan,AYGÜN Hayati,Şenocak Eyüp,GÜNDOĞDU BETÜL Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. Acta Orthopaedica et Traumatologica Turcica 52, no.6 (2018): 469 - 474. 10.1016/j.aott.2018.07.005
MLA Demirel Esra,YILDIZ Kadri,ÇADIRCI Kenan,AYGÜN Hayati,Şenocak Eyüp,GÜNDOĞDU BETÜL Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. Acta Orthopaedica et Traumatologica Turcica, vol.52, no.6, 2018, ss.469 - 474. 10.1016/j.aott.2018.07.005
AMA Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. Acta Orthopaedica et Traumatologica Turcica. 2018; 52(6): 469 - 474. 10.1016/j.aott.2018.07.005
Vancouver Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid. Acta Orthopaedica et Traumatologica Turcica. 2018; 52(6): 469 - 474. 10.1016/j.aott.2018.07.005
IEEE Demirel E,YILDIZ K,ÇADIRCI K,AYGÜN H,Şenocak E,GÜNDOĞDU B "Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid." Acta Orthopaedica et Traumatologica Turcica, 52, ss.469 - 474, 2018. 10.1016/j.aott.2018.07.005
ISNAD Demirel, Esra vd. "Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid". Acta Orthopaedica et Traumatologica Turcica 52/6 (2018), 469-474. https://doi.org/10.1016/j.aott.2018.07.005
Sayfa Oluşturulma Tarihi
23-04-2024 7:38

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