TY  - JOUR
TI  - Effect of platelet-rich fibrin on epidural fibrosis and comparison to ADCON® Gel and hyaluronic acid
AB  - Objective: In this experimental study, PRF (Platelet Rich Fibrin), HA (Hyaluronic Acid) gel and ADCON®Gel were compared in terms of preventing epidural fibrosis.Methods: Twenty-eight SpragueeDawley rats (mean weight, 400e450 g) were divided into 4 groups. L3-L4 laminectomy was performed in each group. Following laminectomy, Adcon® Gel, HA gel and PRF wereapplied onto the surgery site locally in Group 1, 2 and 3, respectively. Group 4 was maintained as controlwithout any local application. After five weeks, L3-L4 vertebrae were removed totally and taken tohistopathological evaluation for epidural fibrosis, acute inflammatory cell density, chronic inflammatorycell density, hemorrhage, angiogenesis and new bone formation.Results: Acute inflammation cell density, angiogenesis, and new bone formation levels were comparableamong the study groups (p > 0.05). However, new bone formation was higher in the PRF group. Epiduralfibrosis and chronic inflammatory cell density were significantly lower in the PRF group (p < 0.05).Conclusion: We concluded that PRF contributed to hemostasis and prevented epidural fibrosis.Crown Copyright © 2018 Turkish Association of Orthopaedics and Traumatology. Publishing services byElsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Hayati Aygün d , Betül Gündogdu e
AU  - Demirel, Esra
AU  - YILDIZ, Kadri
AU  - AYGÜN, Hayati
AU  - ÇADIRCI, Kenan
AU  - Şenocak, Eyüp
AU  - GÜNDOĞDU, BETÜL
DO  - 10.1016/j.aott.2018.07.005
PY  - 2018
JO  - Acta Orthopaedica et Traumatologica Turcica
VL  - 52
IS  - 6
SN  - 1017-995X
SP  - 469
EP  - 474
DB  - TRDizin
UR  - http://search/yayin/detay/295264
ER  -