Chronic migraine (CM) is a common disorder that compromises the quality of life of patients, decreases functionality, is fre-quently misdiagnosed, and has poor response to treatment even when diagnosed. Rare and randomized controlled studies onchronic migraine have revealed limitations within current therapeutic options. While pharmacologic treatment includes acuteand preventive treatment options, it may lead to some adverse effects, which challenge the tolerance of patients. An increasednumber of studies in recent years have shown that behavioral interventions such as cognitive behavioral therapy (CBT), bio-feedback (BFD), relaxation techniques and neurostimulation procedures lead to a significant improvement in the treatment ofchronic migraine. For this reason, such treatment options are recommended, especially in persistent cases with poor responseto treatment. The treatment of chronic migraine is more challenging compared with episodic migraine (EM), and recent studiessuggest that non-pharmacologic approaches and neurostimulation techniques will increase the chance of success in the treat-ment of chronic migraine.