TY  - JOUR
TI  - Real-life results of treatment with ombitasvir, paritaprevir, dasabuvir, and ritonavir combination in patients with chronic renal failure infected with HCV in Turkey
AB  - Background/Aims: As the most common liver disease in hemodialysis patients, chronic hepatitis C (CHC) can cause cirrhosis and hepatocellular carcinoma, even increase in renal-related mortality. In Turkey, the frequency of anti-hepatitis C virus (HCV) antibodies inhemodialysis patients ranged from 31.4% to 51%. Until recently, the mainstay of the CHC treatment for these patients was pegylatedinterferon with potential toxicities and low sustained virological response. The 3D regimen, a combination of four drugs (ombitasvir,paritaprevir, dasabuvir, and ritonavir), has recently been used for patients with chronic kidney disease infected with genotype 1a and 1bHCV. The aim of the present study was to present results of 3D treatment for patients with hemodialysis-dependent chronic renal failure(CRF) who were chronically infected with HCV.Materials and Methods: Overall, 25 patients with hemodialysis-dependent CRF who were infected with genotype 1a/1b HCV havebeen treated using the 3D regimen in our gastroenterology clinic between July 2016 and October 2017. Three patients were administered additional ribavirin 200 mg/day. Serum HCV RNAs, blood chemistry, blood count, and side effects were recorded at 0, 4, and12 weeks.Results: All 25 patients completed and well tolerated their planned treatment. At the end of 4 weeks, the viral response (defined as HCVRNA clearance) rate was 92%. At the end of 12 weeks of treatment and 3 months after treatment, viral response rates were both 100%.Conclusion: We observed that the treatment with 3D regimen in hemodialysis patients infected with genotype 1 hepatitis C is highlyeffective and well tolerated.
AU  - Sezgin, Orhan
AU  - ALTINTAS, ENGIN
AU  - YARAŞ, Serkan
AU  - ATEŞ, Fehmi
AU  - Ucbilek, Enver
AU  - Ozdogan, Osman
PY  - 2019
JO  - Turkish Journal of Gastroenterology
VL  - 30
IS  - 4
SN  - 1300-4948
SP  - 331
EP  - 335
DB  - TRDizin
UR  - http://search/yayin/detay/297873
ER  -