Because of the heterogeneity of the clinical picture and etiology, the diagnosis of cerebral venous sinus thrombosis is often skipped and, even if diagnosed, factors that are usually subclinically contributing are missed or ignored. This condition, which accounts for 1% of all cerebrovascular diseases, is often seen in young adults, but the clinical diagnosis may be delayed due to the heterogeneous clinical condition ranging from isolated headache to coma. It has been shown that trigger elements such as head trauma, delivery, systemic infections cause sinus thrombosis in individuals with genetically increased prothrombotic risk. In this article, we reviewed the effects of complicating factors such as lightning strike and infections in a twenty two years old male patient having underlying genetic predisposition who later diagnosed with cerebral sinus venous thrombosis.