TY  - JOUR
TI  - Evaluation of the histopathological effects of salbutamol inhaler treatment in an experimentally induced rat model of pulmonary contusion
AB  - Background/aim: This study aimed to evaluate the effects of salbutamol inhaler treatment in an experimentally induced model ofpulmonary contusion.Materials and methods: Thirty-two male Wistar albino rats were randomly divided into four groups: the control group (CG), shamgroup (SG), treatment group 1 (TG1), and treatment group 2 (TG2). Experimental contusion was established by targeting the right lungtissue. After 72 h, histopathological evaluation for the severity of edema, hemorrhage, and leukocyte infiltration was performed in bothsides of the lungs.Results: Examination of right lung tissues revealed a significant difference in edema, hemorrhage, leukocyte infiltration, and total lunginjury scores between the CG and SG. Both TG1 and TG2 had less edema, hemorrhage, and leukocyte infiltration and lower total lunginjury scores compared with the SG. There was no significant difference in edema, hemorrhage, and total lung injury scores betweenthe CG and TG1 or TG2. A significant difference in hemorrhage scores between the SG and TG1 and edema scores between the SG andTG2 was observed, with treatment groups having lower values. A significant difference in total lung injury score was also found betweenSG and TG1.Conclusion: Salbutamol inhaler therapy during pulmonary contusion may prevent complications by reducing edema, hemorrhage,leukocyte infiltration, and total lung injury score.
AU  - ARITÜRK, MEHMET ENDER
AU  - Bıçakcı, Unal
AU  - Demirel, Berat Dilek
AU  - Bernay, Riza Ferit
AU  - Hancıoğlu, Sertaç
AU  - Gun, Seda
AU  - AYÇİÇEK, Tuğba
DO  - 10.3906/sag-1805-209
PY  - 2018
JO  - Turkish Journal of Medical Sciences
VL  - 48
IS  - 6
SN  - 1300-0144
SP  - 1285
EP  - 1292
DB  - TRDizin
UR  - http://search/yayin/detay/298979
ER  -