High serum YKL-40 level is associated with poor prognosis in patients with lung cancer

Yıl: 2018 Cilt: 66 Sayı: 4 Sayfa Aralığı: 273 - 279 Metin Dili: İngilizce DOI: 10.5578/tt.67319 İndeks Tarihi: 02-07-2019

High serum YKL-40 level is associated with poor prognosis in patients with lung cancer

Öz:
Introduction: YKL-40 is a glycoprotein that plays role in inflammation and malignant processes. High serum YKL-40 levels areassociated with short survive in cancer and chronic obstructive pulmonary disease (COPD) is another reason to increase its’ level.However, limited knowledges are known in YKL-40 along with lung cancer and COPD.Materials and Methods: One hundred patients were involved tostudy with lung cancer (84 men, 16 women, and median age 62).Results were compared with 30 healthy volunteers. Thirteenpatients were small cell lung cancer (SCLC), 87 patients were nonsmall cell lung cancer (NSCLC). 62% of patients were inoperable.Results: Median YKL-40 level was 222.7 ± 114.1 ng/mL in patientsand was 144.5 ± 105.7 ng/mL in controls (p< 0.001). Stage, tumour size, lymph node involvement and distant metastasis weren’t associated with serum YKL-40 level. Above all cut-off values(133.159 and 162 ng/mL) survival was shorter (p> 0.05). Patients with COPD had worse survive above all cut-off values (p< 0.05),especially according to 133 ng/mL (p= 0.01).Conclusion: YKL-40 level is useful in lung cancer however it’s not related to cell type and prognosis. It is associated with poor prognosis in lung cancer patients with COPD.
Anahtar Kelime:

Konular: Solunum Sistemi Kulak, Burun, Boğaz

Yüksek serum YKL-40 düzeyi akciğer kanserinde kötü prognozla ilişkilidir

Öz:
Giriş: YKL-4 inflamasyon ve malign süreçlerde rol oynayan bir glikoproteindir. Yüksek YKL-40 düzeyi inflamasyonda görüldüğü gibi kanserde kısa yaşam beklentisiyle ilişkilidir. Akciğer kanseri ve kronik obstrüktif akciğer hastalığı (KOAH)’nın serum YKL-40 düzeyi ile ilişkisinin birlikte incelendiği yayın sayısı kısıtlıdır. Materyal ve Metod: Çalışmaya 84 erkek ve 16 kadın olmak üzere 100 hasta dahil edildi. Yaş ortalaması 62 idi. Sonuçlar 30 sağlıklı gönüllü ile karşılaştırıldı. Hastalardan 13 tanesi küçük hücreli akciğer kanseri (KHAK) 87 küçük hücre dışı akciğer kanseri (KHDAK) tanısı aldı. Yüz hastanın 42’sinde KOAH eşlik ediyordu. Bulgular: Hasta grupta ortalama YKL-40 düzeyi 229 ± 110.7 ng/mL iken kontrol grubunda 114.5 ± 105.7 ng/mL saptandı (p< 0.001). Evre, tümör çapı, nodal infiltrasyon ve uzak metastazla YKL-40 düzeyi arasında ilişki saptanmadı. Tüm eşik değerler üzerinde (133.159 ve 162 ng/mL) yaşam süresi daha kısa bulundu (p> 0.05). Özellikle 133 ng/mL‘ye göre KOAH tanılı 42 hastada KOAH olmayanlara göre yaşam süresi anlamlı derecede daha kısaydı (p= 0.01). Sonuç: YKL-40 akciğer kanserinde yararlı bir belirteç ancak hücre tipi ve yaşam süresiyle ilişkisiz. KOAH’ın eşlik ettiği akciğer kanserli hastalarda ise yüksek serum düzeyleri kötü prognozla ilişkili bulunmuştur.
Anahtar Kelime:

Konular: Solunum Sistemi Kulak, Burun, Boğaz
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA CILEDAG A, AKIN KABALAK P, ÇELİK G, DEMİR N, YÜKSEL C, KÖYCÜ G, ÖZTUNA D, Taner A, KAYA A, kutlay h, SAVAŞ İ, NUMANOĞLU N (2018). High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. , 273 - 279. 10.5578/tt.67319
Chicago CILEDAG AYDIN,AKIN KABALAK Pınar,ÇELİK Gökhan,DEMİR Nalan,YÜKSEL Cabir,KÖYCÜ Gözde,ÖZTUNA Derya GÖKMEN,Taner Abbas,KAYA AKIN,kutlay hakan,SAVAŞ İSMAİL,NUMANOĞLU Numan High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. (2018): 273 - 279. 10.5578/tt.67319
MLA CILEDAG AYDIN,AKIN KABALAK Pınar,ÇELİK Gökhan,DEMİR Nalan,YÜKSEL Cabir,KÖYCÜ Gözde,ÖZTUNA Derya GÖKMEN,Taner Abbas,KAYA AKIN,kutlay hakan,SAVAŞ İSMAİL,NUMANOĞLU Numan High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. , 2018, ss.273 - 279. 10.5578/tt.67319
AMA CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. . 2018; 273 - 279. 10.5578/tt.67319
Vancouver CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. . 2018; 273 - 279. 10.5578/tt.67319
IEEE CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N "High serum YKL-40 level is associated with poor prognosis in patients with lung cancer." , ss.273 - 279, 2018. 10.5578/tt.67319
ISNAD CILEDAG, AYDIN vd. "High serum YKL-40 level is associated with poor prognosis in patients with lung cancer". (2018), 273-279. https://doi.org/10.5578/tt.67319
APA CILEDAG A, AKIN KABALAK P, ÇELİK G, DEMİR N, YÜKSEL C, KÖYCÜ G, ÖZTUNA D, Taner A, KAYA A, kutlay h, SAVAŞ İ, NUMANOĞLU N (2018). High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. Tüberküloz ve Toraks, 66(4), 273 - 279. 10.5578/tt.67319
Chicago CILEDAG AYDIN,AKIN KABALAK Pınar,ÇELİK Gökhan,DEMİR Nalan,YÜKSEL Cabir,KÖYCÜ Gözde,ÖZTUNA Derya GÖKMEN,Taner Abbas,KAYA AKIN,kutlay hakan,SAVAŞ İSMAİL,NUMANOĞLU Numan High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. Tüberküloz ve Toraks 66, no.4 (2018): 273 - 279. 10.5578/tt.67319
MLA CILEDAG AYDIN,AKIN KABALAK Pınar,ÇELİK Gökhan,DEMİR Nalan,YÜKSEL Cabir,KÖYCÜ Gözde,ÖZTUNA Derya GÖKMEN,Taner Abbas,KAYA AKIN,kutlay hakan,SAVAŞ İSMAİL,NUMANOĞLU Numan High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. Tüberküloz ve Toraks, vol.66, no.4, 2018, ss.273 - 279. 10.5578/tt.67319
AMA CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. Tüberküloz ve Toraks. 2018; 66(4): 273 - 279. 10.5578/tt.67319
Vancouver CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N High serum YKL-40 level is associated with poor prognosis in patients with lung cancer. Tüberküloz ve Toraks. 2018; 66(4): 273 - 279. 10.5578/tt.67319
IEEE CILEDAG A,AKIN KABALAK P,ÇELİK G,DEMİR N,YÜKSEL C,KÖYCÜ G,ÖZTUNA D,Taner A,KAYA A,kutlay h,SAVAŞ İ,NUMANOĞLU N "High serum YKL-40 level is associated with poor prognosis in patients with lung cancer." Tüberküloz ve Toraks, 66, ss.273 - 279, 2018. 10.5578/tt.67319
ISNAD CILEDAG, AYDIN vd. "High serum YKL-40 level is associated with poor prognosis in patients with lung cancer". Tüberküloz ve Toraks 66/4 (2018), 273-279. https://doi.org/10.5578/tt.67319