TY - JOUR TI - High serum YKL-40 level is associated with poor prognosis in patients with lung cancer AB - Introduction: YKL-40 is a glycoprotein that plays role in inflammation and malignant processes. High serum YKL-40 levels areassociated with short survive in cancer and chronic obstructive pulmonary disease (COPD) is another reason to increase its’ level.However, limited knowledges are known in YKL-40 along with lung cancer and COPD.Materials and Methods: One hundred patients were involved tostudy with lung cancer (84 men, 16 women, and median age 62).Results were compared with 30 healthy volunteers. Thirteenpatients were small cell lung cancer (SCLC), 87 patients were nonsmall cell lung cancer (NSCLC). 62% of patients were inoperable.Results: Median YKL-40 level was 222.7 ± 114.1 ng/mL in patientsand was 144.5 ± 105.7 ng/mL in controls (p< 0.001). Stage, tumour size, lymph node involvement and distant metastasis weren’t associated with serum YKL-40 level. Above all cut-off values(133.159 and 162 ng/mL) survival was shorter (p> 0.05). Patients with COPD had worse survive above all cut-off values (p< 0.05),especially according to 133 ng/mL (p= 0.01).Conclusion: YKL-40 level is useful in lung cancer however it’s not related to cell type and prognosis. It is associated with poor prognosis in lung cancer patients with COPD. AU - ÖZTUNA, Derya GÖKMEN AU - kutlay, hakan AU - KAYA, AKIN AU - DEMİR, Nalan AU - SAVAŞ, İSMAİL AU - KÖYCÜ, Gözde AU - CILEDAG, AYDIN AU - NUMANOĞLU, Numan AU - ÇELİK, Gökhan AU - AKIN KABALAK, Pınar AU - Taner, Abbas AU - YÜKSEL, Cabir DO - 10.5578/tt.67319 PY - 2018 JO - Tüberküloz ve Toraks VL - 66 IS - 4 SN - 0494-1373 SP - 273 EP - 279 DB - TRDizin UR - http://search/yayin/detay/300536 ER -