ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS
Yıl: 2018 Cilt: 21 Sayı: 4 Sayfa Aralığı: 536 - 543 Metin Dili: İngilizce DOI: 10.31086/tjgeri.2018.59 İndeks Tarihi: 05-07-2019
ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS
Öz: Introduction: Vitamin D is known as an anti-inflammatory, antitumor, and immunemodulating hormone, which plays an important role in common diseases in the geriatricpopulation, such as hypertension and cerebrovascular disorders. Vitamin D deficiency has beenlinked to various diseases in the literature. However, the association between vitamin D andmultiple comorbidities remains unclear due to limited published data. The aim of the presentstudy was to evaluate the association between vitamin D levels and multiple comorbidities inelderly patients.Materials and Method: The study design was cross-sectional. Geriatric patients (aged≥65 years) who underwent serum 25(OH)D evaluation to determine the vitamin D statusduring the last 3 months were assessed for eligibility. Demographic data and 25(OH)D levelsof patients were obtained from the electronic database of the hospital and a telephonicinterview. In addition, a comorbidity questionnaire was completed via telephonic interviews.The correlation between comorbidity scores, demographic data, and vitamin D levels in elderlypatients was analyzed.Results: Data on 25(OH)D levels in 685 geriatric patients was obtained. Among thesepatients, 211 (169 female, 42 male) who were contacted over telephone were enrolled. Themean values for age, vitamin D level, and comorbidity scores were 70.4±5.0 years, 16.8±9.2ng/ml, and 11.3±4.7, respectively. A moderate-good negative correlation was found between25(OH)D levels and comorbidity scores (r=−0.503).Conclusion: Low vitamin D levels were associated with total comorbidity status in geriatricpatients. This result suggests that vitamin D deficiency may be a risk factor for comorbiditiesin geriatric patients.
Anahtar Kelime: Konular:
GERİATRİ YAŞ GRUBUNDAKİ HASTALARDA D VİTAMİNİ DÜZEYİ İLE TOTAL KOMORBİDİTE DURUMU ARASINDAKİ İLİŞKİ
Öz: Giriş: Vitamin D, anti-inflamatuvar, anti-tümör ve immünmodulatuvar etkileri nedeniyle; hipertansiyon ve serebrovasküler hastalıklar gibi, geriatrik popülasyonda sık görülen bazı sağlık problemlerinde önemli role sahiptir. Literatürde farklı hastalıklarda vitamin D eksikliğinin rolü gösterilmiştir. Ancak, birden fazla sağlık probleminin olduğu ileri yaş grubunda, vitamin D seviyesi ile komorbidite arasındaki ilişki net değildir. Bu çalışmada, yaşlı hastalarda, vitamin D seviyesi ile komorbidite arasındaki ilişkinin saptanması amaçlanmıştır. Gereç ve Yöntem: Çalışma dizaynı kesitseldir. Son 3 ay içinde 25(OH)D seviyeleri bakılmış olan geriatrik hastalar (≥65 yaş) uygunluk açısından değerlendirildi. Hastane veri tabanından ve telefon görüşmesi ile, hastaların demografik verileri ve 25(OH)D seviyeleri kaydedildi. Ayrıca, telefon görüşmesi ile hastaların komorbidite anketi dolduruldu. Geriatrik hastaların, komorbidite skoru, demografik özellikleri ve serum 25(OH)D düzeyi arasındaki korelasyon değerlendirildi. Bulgular: Veri tabanında 65 yaş ve üzeri toplam 685 hastanın 25(OH)D seviyeleri mevcuttu. Bu hastalardan telefon aracılığıyla ulaşılabilen 211 hasta (169 kadın, 42 erkek) çalışmaya dahil edildi. Hastaların yaş, 25(OH)D düzeyi ve komorbidite skoru için ortalama değerleri sırasıyla; 70.4±5.0 yıl, 16.8±9.2 ng/ml ve 11.3±4.7 idi. Yapılan korelasyon analizinde, serum 25(OH) D seviyesinin, komorbidite skoru ile orta-iyi derecede negatif korele olduğu tespit edildi (r=−0.503). Sonuç: Geriatrik hastalarda düşük vitamin D düzeyleri total komorbidite durumu ile ilişkili bulunmuştur. Bu nedenle, vitamin D eksikliği yaşlı hastalarda komorbidite için bir risk faktörü olarak düşünülebilir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Alkan S, Sarsan A, Alkan H, Yıldız N, Topuz O, Ardıç F. Relationship between balance, physical performance and quality of life with vitamin D levels in the elderly. Turkish Journal of Geriatrics 2012;15(2):156-63.
- Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2014;2(1):76-89. (PMID:24622671).
- Boeckxstaens P, Vaes B, Legrand D, Dalleur O, De Sutter A, Degryse JM. The relationship of multimorbidity with disability and frailty in the oldest patients: a cross-sectional analysis of three measures of multimorbidity in the BELFRAIL cohort. Eur J Gen Pract 2015;21(1):39-44. (PMID:24980394).
- Chen LY, Liu LK, Hwang AC, et al. Impact of malnutrition on physical, cognitive function and mortality among older men living in veteran homes by minimum data set: A Prospective Cohort Study in Taiwan. J Nutr Health Aging 2016 Jan;20(1):41-7. (PMID:26728932).
- de Borst MH, de Boer RA, Stolk RP, Slaets JP, Wolffenbuttel BH, Navis G. Vitamin D deficiency: universal risk factor for multifactorial diseases? Curr Drug Targets 2011;12(1):97-106. (PMID:20795934).
- Dekker J, de Rooij M, van der Leeden M. Exercise and comorbidity: the i3-S strategy for developing comorbidity-related adaptations to exercise therapy. Disabil Rehabil 2016;38(9):905-9. (PMID:26176170).
- Eggers S, Remington PL, Ryan K, Nieto J, Peppard P, Malecki K. Obesity prevalence and health consequences: Findings From the Survey of the Health of Wisconsin, 2008-2013. WMJ 2016;115(5):238-44. (PMID:29095585).
- Güler H, Turhanoğlu A, Özer C. The effect of vitamin D supplementation on balance and quality of life in older women. Turkish Journal of Geriatrics 2008;11(2):57-61.
- Gündüz E, Eskin F, Gündüz M, et al. Effects of sleep quality, income level and comorbid conditions on quality of life in a Turkish Elderly population: A multicenter study. Turkish Journal of Geriatrics 2015;18(2):136-42.
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96(7):1911- 30. (PMID:21646368).
- Karlamangla A, Tinetti M, Guralnik J, Studenski S, Wetle T, Reuben D. Comorbidity in older adults: nosology of impairment, diseases, and conditions. J Gerontol A Biol Sci Med Sci 2007;62(3):296-300. (PMID:17389727).
- Klimek P, Aichberger S, Thurner S. Disentangling genetic and environmental risk factors for individual diseases from multiplex comorbidity networks. Sci Rep 2016 Dec 23;6:39658. (PMID:28008973).
- Liu GL, Pi HC, Hao L, Li DD, Wu YG, Dong J. Vitamin D status is an independent risk factor for global cognitive impairment in peritoneal dialysis patients. PLoS One 2015;10(12):e0143782. (PMID:26630385).
- Marengoni A, Angleman S, Melis R, et al. Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev 2011 Sep;10(4):430-9. (PMID:21402176).
- Meems LM, de Borst MH, Postma DS, et al. Low levels of vitamin D are associated with multimorbidity: results from the LifeLines Cohort Study. Ann Med 2015;47(6):474-81. (PMID:26340085).
- Muschitz C, Kocijan R, Stütz V, et al. Vitamin D levels and comorbidities in ambulatory and hospitalized patients in Austria. Wien Klin Wochenschr 2015;127(17-18):675-84. (PMID:26184408).
- Piccirillo JF, Vlahiotis A, Barrett LB, Flood KL, Spitznagel EL, Steyerberg EW. The changing prevalence of comorbidity across the age spectrum. Crit Rev Oncol Hematol 2008;67(2):124- 32. (PMID:18375141).
- Radner H, Yoshida K, Smolen JS, Solomon DH. Multimorbidity and rheumatic conditions enhancing the concept of comorbidity. Nat Rev Rheumatol 2014;10(4):252-6. (PMID:24418765).
- Rodríguez-Pérez A, Alfaro-Lara ER, Albiñana-Perez S, et al. Novel tool for deprescribing in chronic patients with multimorbidity: List of Evidence-Based Deprescribing for Chronic Patients criteria. Geriatr Gerontol Int 2017;17(11):2200-07. (PMID:28544188).
- Sangha O, Stucki G, Liang MH, Fossel AH, Katz JN. The self-administered comorbidity questionnaire: a new method to assess comorbidity for clinical and health services research. Arthritis and Rheumatism 2003;49(2):156-63. (PMID:12687505).
- Sogomonian R, Alkhawam H, Jolly J, et al. Serum vitamin D levels correlate to coronary artery disease severity: a retrospective chart analysis. Expert Rev Cardiovasc Ther 2016;14(8):977-82. (PMID:27187061).
- Timpini A, Pini L, Tantucci C, Cossi S, Grassi V. Vitamin D and health status in elderly. Intern Emerg Med 2011;6(1):11-21. (PMID:20517656).
- Toscano Guzmán MD, Galván Banqueri M, Otero MJ, Alfaro Lara ER, Casajus Lagranja P, Santos Ramos B. Development of a trigger tool to identify adverse drug events in elderly patients with multimorbidity. J Patient Saf 2017 Jun 14. (PMID:28617720).
- United Nations. World Population Aging: The 2015 Report: 27. [Internet] Available from: http:// www.un.org/en/development/desa/population/ publications/pdf/ageing/WPA2015_Report.pdf. Accessed: 01.12.2017
- Vimaleswaran KS, Cavadino A, Berry DJ, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014;2(9):719-29. (PMID:24974252).
| APA | Gokcen N, COŞKUN BENLİDAYI İ, Kocaer A, Basaran S (2018). ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. , 536 - 543. 10.31086/tjgeri.2018.59 |
| Chicago | Gokcen Neslihan,COŞKUN BENLİDAYI İIke,Kocaer Ahmet,Basaran Sibel ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. (2018): 536 - 543. 10.31086/tjgeri.2018.59 |
| MLA | Gokcen Neslihan,COŞKUN BENLİDAYI İIke,Kocaer Ahmet,Basaran Sibel ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. , 2018, ss.536 - 543. 10.31086/tjgeri.2018.59 |
| AMA | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. . 2018; 536 - 543. 10.31086/tjgeri.2018.59 |
| Vancouver | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. . 2018; 536 - 543. 10.31086/tjgeri.2018.59 |
| IEEE | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S "ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS." , ss.536 - 543, 2018. 10.31086/tjgeri.2018.59 |
| ISNAD | Gokcen, Neslihan vd. "ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS". (2018), 536-543. https://doi.org/10.31086/tjgeri.2018.59 |
| APA | Gokcen N, COŞKUN BENLİDAYI İ, Kocaer A, Basaran S (2018). ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. Türk Geriatri Dergisi, 21(4), 536 - 543. 10.31086/tjgeri.2018.59 |
| Chicago | Gokcen Neslihan,COŞKUN BENLİDAYI İIke,Kocaer Ahmet,Basaran Sibel ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. Türk Geriatri Dergisi 21, no.4 (2018): 536 - 543. 10.31086/tjgeri.2018.59 |
| MLA | Gokcen Neslihan,COŞKUN BENLİDAYI İIke,Kocaer Ahmet,Basaran Sibel ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. Türk Geriatri Dergisi, vol.21, no.4, 2018, ss.536 - 543. 10.31086/tjgeri.2018.59 |
| AMA | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. Türk Geriatri Dergisi. 2018; 21(4): 536 - 543. 10.31086/tjgeri.2018.59 |
| Vancouver | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS. Türk Geriatri Dergisi. 2018; 21(4): 536 - 543. 10.31086/tjgeri.2018.59 |
| IEEE | Gokcen N,COŞKUN BENLİDAYI İ,Kocaer A,Basaran S "ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS." Türk Geriatri Dergisi, 21, ss.536 - 543, 2018. 10.31086/tjgeri.2018.59 |
| ISNAD | Gokcen, Neslihan vd. "ASSOCIATION BETWEEN VITAMIN D LEVEL AND TOTAL COMORBIDITY STATUS IN GERIATRIC PATIENTS". Türk Geriatri Dergisi 21/4 (2018), 536-543. https://doi.org/10.31086/tjgeri.2018.59 |
