Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas

OKTAY, Sehkar

doi:10.12991/marupj.319312

Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas

Sehkar Oktay (Department of Biochemistry, Faculty of Dentistry, Marmara University, 34854, Maltepe, Istanbul, Turkey)

Marmara Pharmaceutical Journal

7 0

Yıl: 2017 Cilt: 21 Sayı: 3 Sayfa Aralığı: 570 - 577 Metin Dili: İngilizce DOI: 10.12991/marupj.319312 İndeks Tarihi: 18-07-2019

Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas

Öz:

Valproic acid (VPA), an effective antiepileptic and anticonvulsant drug, has some toxic side effects due to causing elevated oxidant production. The aim of this study is to investigate the effects of edaravone, a potent free radical scavenger on VPA induced toxicity and tissue damage by biochemical and histological examinations on pancreas. Female Sprague Dawley rats were divided into four groups as follows; control, edaravone, VPA, VPA+edaravon. VPA and edaravone were injected intraperitonally for seven days. Total protein,lipid peroxidation (LPO), sialic acid (SA) and glutathione (GSH) levels and alkaline phosphatase (ALP), tissue factor (TF), superoxide dismutase (SOD), glutathione-S-transferase(GST), catalase (CAT), glutathione peroxidase (GPx) and myeloperoxidase (MPO) activities were determined in pancreas homogenates. In VPA given group, LPO and SA levels, and ALP, TF, MPO activities significantly increased and GST, CAT, GPx activities significantly decreased compared to control group. A marked morphological damage was detected in the VPA group. Ameliorative effects of edaravone were observed in SA, TF, CAT, GPx parameters and histological examination in the VPA group. Therefore, edaravone may be effective in moderation and/or reduction of toxic effects of VPA on pancreas.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	OKTAY S (2017). Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. , 570 - 577. 10.12991/marupj.319312
Chicago	OKTAY Sehkar Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. (2017): 570 - 577. 10.12991/marupj.319312
MLA	OKTAY Sehkar Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. , 2017, ss.570 - 577. 10.12991/marupj.319312
AMA	OKTAY S Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. . 2017; 570 - 577. 10.12991/marupj.319312
Vancouver	OKTAY S Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. . 2017; 570 - 577. 10.12991/marupj.319312
IEEE	OKTAY S "Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas." , ss.570 - 577, 2017. 10.12991/marupj.319312
ISNAD	OKTAY, Sehkar. "Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas". (2017), 570-577. https://doi.org/10.12991/marupj.319312

APA	OKTAY S (2017). Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. Marmara Pharmaceutical Journal, 21(3), 570 - 577. 10.12991/marupj.319312
Chicago	OKTAY Sehkar Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. Marmara Pharmaceutical Journal 21, no.3 (2017): 570 - 577. 10.12991/marupj.319312
MLA	OKTAY Sehkar Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. Marmara Pharmaceutical Journal, vol.21, no.3, 2017, ss.570 - 577. 10.12991/marupj.319312
AMA	OKTAY S Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. Marmara Pharmaceutical Journal. 2017; 21(3): 570 - 577. 10.12991/marupj.319312
Vancouver	OKTAY S Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas. Marmara Pharmaceutical Journal. 2017; 21(3): 570 - 577. 10.12991/marupj.319312
IEEE	OKTAY S "Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas." Marmara Pharmaceutical Journal, 21, ss.570 - 577, 2017. 10.12991/marupj.319312
ISNAD	OKTAY, Sehkar. "Investigation of the Effects of Edaravone on Valproic Acid Induced Tissue Damage in Pancreas". Marmara Pharmaceutical Journal 21/3 (2017), 570-577. https://doi.org/10.12991/marupj.319312