D Vitamini Ve Metabolomik
Yıl: 2018 Cilt: 16 Sayı: 2 Sayfa Aralığı: 127 - 194 Metin Dili: Türkçe İndeks Tarihi: 22-07-2019
D Vitamini Ve Metabolomik
Öz: D vitamini, kemik sağlığındaki önemli rolünün yanı sıra diyabet, kanser ve kardiyovasküler hastalıklargibi pek çok hastalık ile bağlantısı olan ve günümüzde hormon olarak kabul edilen bir moleküldür. Dvitamini düzeyinin değerlendirilmesinde, uzun bir yarı ömre sahip olduğundan 25-hidroksivitamin D[25(OH)D] tercih edilmektedir. Ancak D vitamini metabolitlerinin çeşitli hastalıklardaki patofizyolojikrolünü değerlendirmek için tüm metabolomun incelenmesi gerekmektedir. Bunun için total 25 (OH) Ddüzeylerinin yanı sıra serbest/biyoyararlanılabilir formlar, D vitamini bağlayıcı protein (DBP),parathormon ve 1, 25 (OH) 2 D3, 3-epi-25 (OH) D, 24,25 (OH) 2 D3 gibi diğer belirteçleri içerenmetabolomik bir panele gereksinim vardır. Gelecekte D vitamini metabolomiğinin kapsamlı bir şekildeincelenmesi için kütle spektrometreleri potansiyel vaat etmektedir.
Anahtar Kelime: Konular:
Metabolomics Approach in Vitamin D
Öz: Vitamin D is a molecule, now seen as a hormone, it plays an important role in bone health, it is also associated with many diseases, such as diabetes, cancer and cardiovascular problems. 25- hydroxyvitamin D [25(OH)D] is used to estimate vitamin D status because its long half-life. However, to understand the pathophysiological role of vitamin D metabolites on various diseases, we need to evaluate all relevant metabolome. For this reason, a metabolomic panel is required to evaluate the vitamin D status that measurement of 25 (OH) D and other vitamin D biomarkers, e.g., 1α,25 (OH)2 D3 , 3-epi-25 (OH) D, 24,25 (OH)2 D3, vitamin D binding protein (DBP), free/bioavailable 25 (OH) D and parathyroid hormone. Mass spectrometers are promising for comprehensive analysis of vitamin D metabolites in the future.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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| APA | Karatoy Erdem B, AKBAŞ S (2018). D Vitamini Ve Metabolomik. , 127 - 194. |
| Chicago | Karatoy Erdem Bilge,AKBAŞ SADIKA HALİDE D Vitamini Ve Metabolomik. (2018): 127 - 194. |
| MLA | Karatoy Erdem Bilge,AKBAŞ SADIKA HALİDE D Vitamini Ve Metabolomik. , 2018, ss.127 - 194. |
| AMA | Karatoy Erdem B,AKBAŞ S D Vitamini Ve Metabolomik. . 2018; 127 - 194. |
| Vancouver | Karatoy Erdem B,AKBAŞ S D Vitamini Ve Metabolomik. . 2018; 127 - 194. |
| IEEE | Karatoy Erdem B,AKBAŞ S "D Vitamini Ve Metabolomik." , ss.127 - 194, 2018. |
| ISNAD | Karatoy Erdem, Bilge - AKBAŞ, SADIKA HALİDE. "D Vitamini Ve Metabolomik". (2018), 127-194. |
| APA | Karatoy Erdem B, AKBAŞ S (2018). D Vitamini Ve Metabolomik. Türk Klinik Biyokimya Dergisi, 16(2), 127 - 194. |
| Chicago | Karatoy Erdem Bilge,AKBAŞ SADIKA HALİDE D Vitamini Ve Metabolomik. Türk Klinik Biyokimya Dergisi 16, no.2 (2018): 127 - 194. |
| MLA | Karatoy Erdem Bilge,AKBAŞ SADIKA HALİDE D Vitamini Ve Metabolomik. Türk Klinik Biyokimya Dergisi, vol.16, no.2, 2018, ss.127 - 194. |
| AMA | Karatoy Erdem B,AKBAŞ S D Vitamini Ve Metabolomik. Türk Klinik Biyokimya Dergisi. 2018; 16(2): 127 - 194. |
| Vancouver | Karatoy Erdem B,AKBAŞ S D Vitamini Ve Metabolomik. Türk Klinik Biyokimya Dergisi. 2018; 16(2): 127 - 194. |
| IEEE | Karatoy Erdem B,AKBAŞ S "D Vitamini Ve Metabolomik." Türk Klinik Biyokimya Dergisi, 16, ss.127 - 194, 2018. |
| ISNAD | Karatoy Erdem, Bilge - AKBAŞ, SADIKA HALİDE. "D Vitamini Ve Metabolomik". Türk Klinik Biyokimya Dergisi 16/2 (2018), 127-194. |
