THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL

MENEKŞE, Güner; Yaman, Mesut Emre; Kaptanoglu, Erkan; ERBAY, Fatma Kübra; ERGÜL, Gülüşan; Guvenc, Yahya; ÖZCAN, Abdullah; OZTURK, Yasar; TOLUNAY, TOLGA

THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL

Yahya GÜVENÇ, (Marmara Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Mesut Emre YAMAN, (Gazi Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, Ankara, Türkiye)

Yasar OZTURK, (Yıldırım Beyazıt Üniversitesi, Yenimahalle Eğitim ve Araştırma Hastanesi, Nöroşirurji Kliniği, Ankara, Türkiye)

Gülüşan ERGÜL, (Yenimahalle Eğitim ve Araştırma Hastanesi, Patoloji Anabilim Dalı, Ankara, Türkiye)

Fatma Kübra ERBAY, (TOBB Ekonomi ve Teknoloji Üniversitesi, Ankara, Türkiye)

Tolga TOLUNAY, (Ankara Yenimahalle Eğitim ve Araştırma Hastanesi, Ortopedi ve Travmatoloji Kliniği, Ankara, Türkiye)

Güner MENEKŞE, (Ankara Eğitim ve Araştırma Hastanesi, Nöroşirürji Kliniği, Ankara, Türkiye)

Abdullah ÖZCAN, (Marmara Üniversitesi, Nörolojik Bilimler Enstitüsü, Anesteziyoloji ve Reanimasyon Kliniği, İstanbul, Türkiye)

Erkan KAPTANOĞLU (Marmara Üniversitesi, Tıp Fakültesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)

Journal of Turkish Spinal Surgery

5 2

Yıl: 2018 Cilt: 29 Sayı: 3 Sayfa Aralığı: 141 - 146 Metin Dili: İngilizce İndeks Tarihi: 23-07-2019

THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL

Öz:

Aim: The development of epidural fibrosis after laminectomy lead to postoperative morbidities, persistent radicular pain and failed back syndrome. Various materials or drugs have been used to inhibit formation of epidural fibrosis and reduce the compressive effect on neural structures. Nevertheless, the effects are not satisfied. NAC has mucolytic, antioxidant and anti-inflammatory effect. The aim of this study was to evaluate the effect of NAC on spinal epidural fibrosis in the post-laminectomy rat model.Methods: Twenty-four albino rats were divided randomly into three equal groups: control, spongostan and Local NAC. Each animal underwent a laminectomy. Local NAC group (n=8): 100mg/kg was locally applied with a spongostan soaked with 0,5 ml of the solution and was left on the dura mater. At 4 weeks post surgery, the animals euthanized and their tissue samples at the laminectomy site were assessed histological evaluation for dura thickness, epidural fibrosis grading, inflammatory response grading and presence of arachnoidal involvement. All data were evaluated by statistically.Results: Epidural fibrosis were observed significant lower in the NAC group when compared with control group (p= 0.001) . Inflamattory cell density was significant lower in the NAC group when compared with control and spongostan group(p=0.001 and p=0.015, respectively). Arachnoidal involvement was not observed in NAC group. The differences between all groups weren’t statistically significant for dura thickness and fibloblastic density (p=0.162 and p=0.056, respectively, Kruskal Wallis test)Conclusion: The results of our study suggested that NAC has anti-fibrotic effects on epidural fibrosis in the post-laminectomy rat model.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Guvenc Y, Yaman M, OZTURK Y, ERGÜL G, ERBAY F, TOLUNAY T, MENEKŞE G, ÖZCAN A, Kaptanoglu E (2018). THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. , 141 - 146.
Chicago	Guvenc Yahya,Yaman Mesut Emre,OZTURK Yasar,ERGÜL Gülüşan,ERBAY Fatma Kübra,TOLUNAY TOLGA,MENEKŞE Güner,ÖZCAN Abdullah,Kaptanoglu Erkan THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. (2018): 141 - 146.
MLA	Guvenc Yahya,Yaman Mesut Emre,OZTURK Yasar,ERGÜL Gülüşan,ERBAY Fatma Kübra,TOLUNAY TOLGA,MENEKŞE Güner,ÖZCAN Abdullah,Kaptanoglu Erkan THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. , 2018, ss.141 - 146.
AMA	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. . 2018; 141 - 146.
Vancouver	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. . 2018; 141 - 146.
IEEE	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E "THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL." , ss.141 - 146, 2018.
ISNAD	Guvenc, Yahya vd. "THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL". (2018), 141-146.

APA	Guvenc Y, Yaman M, OZTURK Y, ERGÜL G, ERBAY F, TOLUNAY T, MENEKŞE G, ÖZCAN A, Kaptanoglu E (2018). THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. Journal of Turkish Spinal Surgery, 29(3), 141 - 146.
Chicago	Guvenc Yahya,Yaman Mesut Emre,OZTURK Yasar,ERGÜL Gülüşan,ERBAY Fatma Kübra,TOLUNAY TOLGA,MENEKŞE Güner,ÖZCAN Abdullah,Kaptanoglu Erkan THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. Journal of Turkish Spinal Surgery 29, no.3 (2018): 141 - 146.
MLA	Guvenc Yahya,Yaman Mesut Emre,OZTURK Yasar,ERGÜL Gülüşan,ERBAY Fatma Kübra,TOLUNAY TOLGA,MENEKŞE Güner,ÖZCAN Abdullah,Kaptanoglu Erkan THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. Journal of Turkish Spinal Surgery, vol.29, no.3, 2018, ss.141 - 146.
AMA	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. Journal of Turkish Spinal Surgery. 2018; 29(3): 141 - 146.
Vancouver	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL. Journal of Turkish Spinal Surgery. 2018; 29(3): 141 - 146.
IEEE	Guvenc Y,Yaman M,OZTURK Y,ERGÜL G,ERBAY F,TOLUNAY T,MENEKŞE G,ÖZCAN A,Kaptanoglu E "THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL." Journal of Turkish Spinal Surgery, 29, ss.141 - 146, 2018.
ISNAD	Guvenc, Yahya vd. "THE PREVENTION EFFECT OF N-ACETYLCYSTEINE ON EPIDURAL FIBROSIS IN THE POST- LAMINECTOMY RAT MODEL". Journal of Turkish Spinal Surgery 29/3 (2018), 141-146.