CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin

ALKAN, Hasan; Alcigir, Mehmet Eray; GÜLTİKEN, Nilgün; ANADOL, ELVAN; KANCA, HALİT; KARAKAŞ ALKAN, KÜBRA

doi:10.30607/kvj.368924

CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin

MEHMET ERAY ALÇIĞIR, (Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Dışkapı, Ankara, Turkey)

Elvan ANADOL, (Gazi University Laboratory Animal Breeding and Experimental Research Center, Faculty of Medicine, Gazi University, Beşevler, Ankara, Turkey)

Nilgün GÜLTİKEN, (Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ondokuzmayıs University, Kurupelit, Samsun, Turkey)

KÜBRA KARAKAŞ ALKAN, (Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ankara University, Dışkapı, Ankara, Turkey)

Hasan ALKAN, (Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Selçuk University, Konya, Turkey)

Halit KANCA (Department of Obstetrics and Gynecology, Faculty of Veterinary Medicine, Ankara University, Dışkapı, Ankara, Turkey)

Kocatepe Veterinary Journal

4 0

Yıl: 2018 Cilt: 11 Sayı: 2 Sayfa Aralığı: 104 - 112 Metin Dili: İngilizce DOI: 10.30607/kvj.368924 İndeks Tarihi: 16-09-2019

CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin

Öz:

Canine mammary tumors (CMT) included complex interactions in the etiopathogenesis. It is the most common problemof neoplasia in female dogs. The aim of this study was to reveal the roles of chemokine CXC Ligand 12 (CXCL12) and Gprotein coupled receptor 30 (GPCR30) expressions in the inflammatory process and neoplastic development in caninemammary glands. Therefore, after clinical and pathomorphological evaluation, 18 cases of mixed origin malignant forms(mixed-type carcinoma-n=6, complex-type carcinoma-n=3, carcinosarcoma-n=7, carcinoma and malignantmyoepithelioma-n=2)] were examined in the study. Inflammatory cells accompanying neoplastic changes, were determinedto consist of predominantly neutrophils and leukocytes, followed by lymphocytes, plasma cells and macrophages. TheCXCL12 and GPCR30 expressions were scored. immunohistochemically. Most of the expressions for both markers weremoderate in the mammary gland and duct epithelial cells, myoepithelial cells and inflammatory cells. Fibrocytes andfibroblasts gave a mild reaction in general, and no reaction was found in the myxoid, chondroid and osteoid matrix. Therewas considered to be a close relationship between mixed composition CMT and subacute inflammation, and thus it wasconcluded that inflammtory cells may trigger or initiate neoplastic transformation in the cellular environment includingdifferentiated cells of the mammary gland.

Anahtar Kelime:

Konular: Veterinerlik

Mikst Orjinli Köpek Meme Tümörlerinde CXC Chemokine Ligand 12 ve G Protein Coupled Receptor 30 Ekspresyonları

Öz:

Köpek meme tümörleri etiyopatogenezinde karmaşık bir seri etkileşimleri içerir. Dişi köpeklerde en yaygın karşılaşılan problemdir. Bu çalışmada, köpek meme tümörlerinde yangısal süreç ve tümör gelişimde bir çeşit chemokin olan chemokine CXC Ligand 12 (CXCL12) ile G protein coupled receptor 30 (GPCR30) ekspresyonlarının rollerini ortaya koymak amaçlandı. Bu amaçla, klinik ve patomorfolojik değerlendirmeden sonra, malignant formda mikst orjinli 18 olgu (mixedtype carcinoma-n=6, complex-type carcinoma-n=3, carcinosarcoma-n=7, carcinoma and malignant myoepithelioma-n=2) çalışmaya dahil edildi. Neoplazik değişikliklere eşlik eden yangısal hücreler ağırlıklı olarak nötrofil lökosit ve sırasıyla lenfosit, plazma hücresi ile makrofajlardan oluşuyordu. İmmunohistokimyasal olarak CXCL12 ve GPCR30 ekpsresyonları skorlandı. Her iki belirteçte ekspresyonların çoğu meme bezleri, duktal epitel hücreler, miyoepitel hücreleri ile yangısal hücrelerde orta şiddetteydi. Ancak, fibrosit ve fibroblastlarda genelde hafif şiddetteydi. Mikst orjinli köpek meme tümörleri ile subakut yangı arasında yakın bir ilişki olduğu düşünüldü. Ayrıca, yangısal hücrelerin meme bezlerinin farklılaşmasını içeren hücresel çevrenin bu mikst neoplazik dönüşümünü tetikleyebileceği veya başlatabileceği sonucuna varıldı.

Anahtar Kelime:

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Alcigir M, ANADOL E, GÜLTİKEN N, KARAKAŞ ALKAN K, ALKAN H, KANCA H (2018). CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. , 104 - 112. 10.30607/kvj.368924
Chicago	Alcigir Mehmet Eray,ANADOL ELVAN,GÜLTİKEN Nilgün,KARAKAŞ ALKAN KÜBRA,ALKAN Hasan,KANCA HALİT CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. (2018): 104 - 112. 10.30607/kvj.368924
MLA	Alcigir Mehmet Eray,ANADOL ELVAN,GÜLTİKEN Nilgün,KARAKAŞ ALKAN KÜBRA,ALKAN Hasan,KANCA HALİT CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. , 2018, ss.104 - 112. 10.30607/kvj.368924
AMA	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. . 2018; 104 - 112. 10.30607/kvj.368924
Vancouver	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. . 2018; 104 - 112. 10.30607/kvj.368924
IEEE	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H "CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin." , ss.104 - 112, 2018. 10.30607/kvj.368924
ISNAD	Alcigir, Mehmet Eray vd. "CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin". (2018), 104-112. https://doi.org/10.30607/kvj.368924

APA	Alcigir M, ANADOL E, GÜLTİKEN N, KARAKAŞ ALKAN K, ALKAN H, KANCA H (2018). CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. Kocatepe Veterinary Journal, 11(2), 104 - 112. 10.30607/kvj.368924
Chicago	Alcigir Mehmet Eray,ANADOL ELVAN,GÜLTİKEN Nilgün,KARAKAŞ ALKAN KÜBRA,ALKAN Hasan,KANCA HALİT CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. Kocatepe Veterinary Journal 11, no.2 (2018): 104 - 112. 10.30607/kvj.368924
MLA	Alcigir Mehmet Eray,ANADOL ELVAN,GÜLTİKEN Nilgün,KARAKAŞ ALKAN KÜBRA,ALKAN Hasan,KANCA HALİT CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. Kocatepe Veterinary Journal, vol.11, no.2, 2018, ss.104 - 112. 10.30607/kvj.368924
AMA	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. Kocatepe Veterinary Journal. 2018; 11(2): 104 - 112. 10.30607/kvj.368924
Vancouver	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin. Kocatepe Veterinary Journal. 2018; 11(2): 104 - 112. 10.30607/kvj.368924
IEEE	Alcigir M,ANADOL E,GÜLTİKEN N,KARAKAŞ ALKAN K,ALKAN H,KANCA H "CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin." Kocatepe Veterinary Journal, 11, ss.104 - 112, 2018. 10.30607/kvj.368924
ISNAD	Alcigir, Mehmet Eray vd. "CXC Chemokine Ligand 12 and G Protein-Coupled Receptor 30 Expressions in Canine Mammary Tumors of Mixed Origin". Kocatepe Veterinary Journal 11/2 (2018), 104-112. https://doi.org/10.30607/kvj.368924