Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study
Yıl: 2018 Cilt: 55 Sayı: 1 Sayfa Aralığı: 15 - 21 Metin Dili: İngilizce DOI: 10.29399/npa.12667 İndeks Tarihi: 26-09-2019
Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study
Öz: Objective: Clinically isolated syndrome (CIS) is a clinical state thatproceeds with inflammation and demyelination, suggestive of multiplesclerosis (MS) in the central nervous system in the absence of otheralternative diagnoses. The purpose of this study was to determine ina prospective cohort, the predictor factors in conversion from CISto MS on the basis of clinical, magnetic resonance (MR) imaging andcerebrospinal fluid (CSF) findings.Methods: Forty-one CIS patients were included in this study andfollowed up for at least two years.Results: Clinically, polysymptomatic or sensorial involvement, goodprognostic factors and complete response to pulse therapy were foundto be of prognostic value in conversion to MS. A greater presenceof oligoclonal bands in CSF was identified in the converted group(92.8%). In terms of localization, presence of callosal lesion (71.4%),periventricular lesion (97.1%), Gd-enhanced lesion (48.6%), black hole(54.2%) and brainstem lesion (57.1%) was statistically significant in termsof conversion to MS.Conclusion: A carefully performed neurological assessment ofsymptoms and signs, and evaluation of lesions on MR combined withCSF findings are important for identifying the risk of conversion to MS.This information may be useful when considering treatment in CISpatients instead of waiting for conversion to MS.
Anahtar Kelime: Konular:
Klinik İzole Sendromdan Multipl Skleroza Dönüşümü Temel Özelliklere Bağlı Olarak Öngörebilme
Öz: Amaç: Klinik izole sendrom, diğer alternatif tanıların yokluğunda multipl sklerozu (MS) düşündüren, santral sinir sisteminin inflamasyonu ve demiyelinizasyonu ile giden bir klinik durumdur. Bu çalışmada amacımız; klinik izole sendrom (KİS)’dan MS’e dönüşümü etkileyen öngörü etmenlerini klinik, MR görüntüleme ve beyin omurilik sıvısı (BOS) bulguları temelinde tanımlamaktır. Yöntem: Çalışmaya 41 KİS hastası alındı ve en az iki yıl süreyle takip edildi. Bulgular: Klinik olarak, polisemptomatik ve duyusal tutulum, iyi prognostik faktörler ve puls tedaviye tam yanıtın, MS’e dönüşümde prognostik değere sahip oldukları bulundu. BOS’ta oligoklonal bant (OKB) varlığı, MS’e dönen grupta daha fazla saptandı (%92,8). Beyinde lezyon lokalizasyonları incelendiğinde; korpus kallosum (%71,4), periventriküler lezyon (%97,1), beyin sapında lezyonu varlığı (%57,1), kara delik (%54,2) ve kontrast tutan lezyon varlığı (%48,6), MS’e dönüşümde anlamlı olarak değerlendirilmiştir. Sonuç: Hastanın semptom ve bulgularının nörolojik değerlendirmesinin dikkatlice yapılması ve MR’daki lezyonların ve BOS bulgularının değerlendirilmesi, KİS’ten MS’e dönüşüm riskinin tanımlanmasında oldukça önemlidir. Bu bilgiler, KİS hastalarında MS’e dönüşümü beklemeden tedavi planlanmasında kullanılabilir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | CINAR B, ÖZAKBAŞ S (2018). Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. , 15 - 21. 10.29399/npa.12667 |
| Chicago | CINAR Bilge Piri,ÖZAKBAŞ Serkan Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. (2018): 15 - 21. 10.29399/npa.12667 |
| MLA | CINAR Bilge Piri,ÖZAKBAŞ Serkan Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. , 2018, ss.15 - 21. 10.29399/npa.12667 |
| AMA | CINAR B,ÖZAKBAŞ S Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. . 2018; 15 - 21. 10.29399/npa.12667 |
| Vancouver | CINAR B,ÖZAKBAŞ S Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. . 2018; 15 - 21. 10.29399/npa.12667 |
| IEEE | CINAR B,ÖZAKBAŞ S "Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study." , ss.15 - 21, 2018. 10.29399/npa.12667 |
| ISNAD | CINAR, Bilge Piri - ÖZAKBAŞ, Serkan. "Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study". (2018), 15-21. https://doi.org/10.29399/npa.12667 |
| APA | CINAR B, ÖZAKBAŞ S (2018). Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi, 55(1), 15 - 21. 10.29399/npa.12667 |
| Chicago | CINAR Bilge Piri,ÖZAKBAŞ Serkan Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi 55, no.1 (2018): 15 - 21. 10.29399/npa.12667 |
| MLA | CINAR Bilge Piri,ÖZAKBAŞ Serkan Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi, vol.55, no.1, 2018, ss.15 - 21. 10.29399/npa.12667 |
| AMA | CINAR B,ÖZAKBAŞ S Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi. 2018; 55(1): 15 - 21. 10.29399/npa.12667 |
| Vancouver | CINAR B,ÖZAKBAŞ S Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study. Nöropsikiyatri Arşivi. 2018; 55(1): 15 - 21. 10.29399/npa.12667 |
| IEEE | CINAR B,ÖZAKBAŞ S "Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study." Nöropsikiyatri Arşivi, 55, ss.15 - 21, 2018. 10.29399/npa.12667 |
| ISNAD | CINAR, Bilge Piri - ÖZAKBAŞ, Serkan. "Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study". Nöropsikiyatri Arşivi 55/1 (2018), 15-21. https://doi.org/10.29399/npa.12667 |
