TY  - JOUR
TI  - Prediction of Conversion from Clinically Isolated Syndrome to Multiple Sclerosis According to Baseline Characteristics: A Prospective Study
AB  - Objective: Clinically isolated syndrome (CIS) is a clinical state thatproceeds with inflammation and demyelination, suggestive of multiplesclerosis (MS) in the central nervous system in the absence of otheralternative diagnoses. The purpose of this study was to determine ina prospective cohort, the predictor factors in conversion from CISto MS on the basis of clinical, magnetic resonance (MR) imaging andcerebrospinal fluid (CSF) findings.Methods: Forty-one CIS patients were included in this study andfollowed up for at least two years.Results: Clinically, polysymptomatic or sensorial involvement, goodprognostic factors and complete response to pulse therapy were foundto be of prognostic value in conversion to MS. A greater presenceof oligoclonal bands in CSF was identified in the converted group(92.8%). In terms of localization, presence of callosal lesion (71.4%),periventricular lesion (97.1%), Gd-enhanced lesion (48.6%), black hole(54.2%) and brainstem lesion (57.1%) was statistically significant in termsof conversion to MS.Conclusion: A carefully performed neurological assessment ofsymptoms and signs, and evaluation of lesions on MR combined withCSF findings are important for identifying the risk of conversion to MS.This information may be useful when considering treatment in CISpatients instead of waiting for conversion to MS.
AU  - ÖZAKBAŞ, Serkan
AU  - CINAR, Bilge Piri
DO  - 10.29399/npa.12667
PY  - 2018
JO  - Nöropsikiyatri Arşivi
VL  - 55
IS  - 1
SN  - 1309-4866
SP  - 15
EP  - 21
DB  - TRDizin
UR  - http://search/yayin/detay/308258
ER  -