TY  - JOUR
TI  - Blink Reflex in Episodic and Chronic Migraine
AB  - Introduction: Activation of the trigeminovascular system andsensitization of brainstem trigeminal nuclei play a significant role in thephysiopathology of migraine. Our aim was to investigate blink reflex (BR)and its recovery in episodic and chronic migraine patients.Methods: Twenty-eight chronic migraine patients, thirty-two episodicmigraine without aura patients and thirty healthy controls wereincluded in the study. The study was performed using a portableelectromyography device with a software specifically prepared for BR.Blink reflex assessments were performed in patients during the painfreeperiod and in healthy controls using the ‘standard method - doublestimulation’ technique in 200 ms, 500 ms, 1000 ms, 2000 ms, and 5000ms intervals.Results: Blink reflex recovery was significantly increased in both patientgroups as compared to the control group in 200 ms interstimulus interval(ISI) on both sides (p<0.005). Moreover, when it was compared to thecontrol group, recovery was also significantly increased in the chronicmigraine group in 2000 ms ISI on the right side and in 5000 ms ISI on theleft side as well as in 500 and 1000 ms ISIs on the left side in the migrainewithout aura group (p<0.002, p<0.003). R2 recovery curve was noted to behigher in both patient groups as compared to the control group, althoughcould not be demonstrated statistically in all intervals. A statisticallysignificant increase was observed in the migraine group without aurascompared with the controls (p <0,037, p <0,011) in the left side at 500and 1000 ms ISIs. For all intervals in our study, although the increase inrecovery was not statistically significant, it was noted that the R2 recoverycurve was higher in the patient groups, with respect to the normals. Theincrease in R2 recovery noted in both patient groups suggested increasedsensitization of the trigeminal structures. Significantly increased recoveryin low ISI (200 ms) in the two patient groups as compared to the controlgroup raised the thought that the migraine brain goes through twodifferent excitability periods (ictal and interictal).Conclusion: In conclusion, similar to the previous studies, the findingsof this study suggested that there was a reduction in central inhibitorymechanisms during interictal period in migraine patients.
AU  - Altunkaynak, Yavuz
AU  - Baybas, Sevim
AU  - HELVACI YILMAZ, Nesrin
AU  - AYSAL, Fikret
AU  - MUTLUAY, Belgin
AU  - ÖZTÜRK, Musa
AU  - POLAT, BURCU
DO  - 10.5152/npa.2017.12753
PY  - 2018
JO  - Nöropsikiyatri Arşivi
VL  - 55
IS  - 2
SN  - 1309-4866
SP  - 146
EP  - 151
DB  - TRDizin
UR  - http://search/yayin/detay/308412
ER  -