TY  - JOUR
TI  - Neutrophil gelatinase associated lipocalin, an early biomarker for diagnosis of acute kidney injury after percutaneous coronary intervention
AB  - Objectives: This study was designed to find the reliabilityof serum NGAL as an early and better diagnostic biomarkerthan that of serum creatinine for acute kidneyinjury after percutaneous coronary intervention inPakistanipopulation.Materials and methods: One hundred and fifty-onepatients undergoing elective percutaneous coronaryintervention were included and demographic data wererecorded. Blood was drawn by venipuncture in clot activatorvacutainers and serum was separated and stored at4°C. Sample was drawn before the percutaneous procedureand subsequently sampling was done serially for 5 days.Results: The mean ± SD serum NGAL pre-PCI (39.92 ±10.35 μg/L) and 4 h post-PCI (100.42 ± 26.07 μg/L) showedhighly significant difference (p < 0.001). The mean ± SDserum creatinine pre-PCI (70.1 ± 11.8 μmol/L) and post-PCI (71.2 ± 11.6 μmol/L) showed significant difference(p = 0.005) on day 2 onwards but mean microalbuminshowed insignificant results (p = 0.533). The serum NGALpredicted CI-AKI with sensitivity of 95.8% and specificityof 97.6% for a cut off value of 118 μg/L.Conclusion: Our results suggest that NGAL is an excellentearly diagnostic biomarker for acute kidney injuryin patients undergoing elective percutaneous coronaryintervention.
AU  - Haq, Fahim Ul
AU  - MAHMOOD, Sadia
AU  - CHOUDHRY, Nakhshab
AU  - GONDAL, Aamir Jamal
AU  - IHSAN, Amna
DO  - 10.1515/tjb-2017-0004
PY  - 2018
JO  - Türk Biyokimya Dergisi
VL  - 43
IS  - 1
SN  - 1303-829X
SP  - 15
EP  - 21
DB  - TRDizin
UR  - http://search/yayin/detay/309090
ER  -