TY  - JOUR
TI  - The effects of hydraulic calcium silicate containing endodontic materials on oxidative stress in erythrocytes and liver
AB  - Objective: The aim of this study was to evaluate the effectsof hydraulic calcium silicate endodontic cements, MTAAngelus, MTA Fillapex, and Theracal LC, on erythrocyteand liver oxidative stress parameters of rats.Methods: Right upper incisor of each rat was extractedand polyethylene tubes containing the dental cements,or left empty for the control group, were inserted into theextraction socket. Blood and liver samples of each animalwere obtained after 7, 30, or 60 days. Thiobarbituric acidreactive substances (TBARS) levels and catalase (CAT),superoxide dismutase (SOD), and glutathione peroxidase(GPx) activities were determined by spectrophotometry.Results: Erythrocyte and liver TBARS levels, and CAT andSOD enzymatic activities were significantly increased indental cement applied groups compared with controls onday 7. The highest erythrocyte and liver TBARS concentrationswere observed in the MTA Angelus group on day 7of exposure. On day 30, erythrocyte CAT activity remainedmarkedly high, but the other parameters returned toalmost normal levels. On day 60, all parameters weresimilar between the control and the experimental groups.Conclusions: This is the first study to show that TBARSlevels and antioxidant enzyme activities are transientlyincreased as a result of dental cement application.
AU  - Erdem, Onur
AU  - TUNCA, Yaşar Meriç
AU  - DEMİRDÖĞEN, Birsen Can
AU  - Demirkaya, kadriye
AU  - ÖNCEL TORUN, Zeynep
DO  - 10.1515/tjb-2016-0263
PY  - 2018
JO  - Türk Biyokimya Dergisi
VL  - 43
IS  - 3
SN  - 1303-829X
SP  - 333
EP  - 341
DB  - TRDizin
UR  - http://search/yayin/detay/309304
ER  -