Background and Aims: We conducted a study with a large number of patients to contribute to the epidemiological information in the literature on prevalence, histology, size, and localization of colon polyps. Materials and Methods: Between 2012 and 2017, 2.512 patients underwent colonoscopy to determine colon polyp prevalence, histology (hyperplastic, adenomatous, and serrated), size (<1 cm and >1 cm), and localization (rectum, sigmoid colon, descending colon, and transverse colon). Results: Polyps were de-tected in 876 (34,9%) of 2.512 patients who were included in the study. Hy-perplastic polyps were detected in 104 (11,9%) patients, serrated polyps in 10 (1,1%) patients, and adenomatous polyps in 650 (74.3%) patients. Most (696, 79,4%) detected polyps were smaller than 1 cm, but 180 (20,6%) were larger than 1 cm. According to the localization of polyps, 323 (36,9%) were detected in the rectal region, whereas the percentage of polyps in the prox-imal colon segments decreased. As age increased, the incidence of polyps, adenomatous histology, and polyps increased. When compared with that in females, the percentage of polyp prevalence was higher in males. How-ever, females had a higher rate of polyps larger than 1 cm when compared with males. Conclusion: Our study has meaningful results due to the high number of patients. In particular, the high prevalence of polyps we detected according to data reported in the literature should encourage all clinicians to establish a carefully executed screening program.